Le modèle de l’inactivation du chromosome X chez la souris
Lucie Delaroche,Lucie Delaroche,Pauline Demailly,Katia Ancelin,Catherine Patrat,Catherine Patrat +5 more
Reads0
Chats0
TLDR
An update of the main molecular steps and hypothesis underlining this complex process of X chromosome inactivation in mouse is provided.Abstract:
X chromosome inactivation (XCI) is an excellent model for studying how epigenetic marks are initiated during early embryogenesis. XCI is an essential process that takes place in females, leading to dosage compensation between males and females. In mouse, it occurs in two waves: the first one is paternally imprinted, during the preimplantation period and the second one occurs in a random fashion. We provide here an update of the main molecular steps and hypothesis underlining this complex process.read more
Citations
More filters
Journal ArticleDOI
Is the resulting phenotype of an embryo with balanced X-autosome translocation, obtained by means of preimplantation genetic diagnosis, linked to the X inactivation pattern?
Fatma Ferfouri,I. Bernicot,Anouck Schneider,Emmanuelle Haquet,Bernard Hedon,Tal Anahory,Tal Anahory +6 more
TL;DR: It is necessary to be cautious regarding to PGD management for this type of translocation, particularly in transferred female embryos, and to be at risk of being an abnormal phenotype in the field of PGD.
Journal ArticleDOI
Inactivation du chromosome X chez l’humain - XACT et XIST, à chacun son chromosome
Céline Vallot,Claire Rougeulle +1 more
TL;DR: Ces résultats indiquent que le processus d’inactivation n’est pas strictement dépendant de XIST chez l’humain, contrairement à ce qui a été montré Inactivation du chromosome X chez L’Humain XACT and XIST, à chacun son chromosome.
Journal ArticleDOI
L’héritage de Mary F. Lyon (1925-2014)
Jean-Louis Guénet,Jean-Jacques Panthier,Philip Avner,Philip Avner,Edith Heard,Edith Heard,Xavier Montagutelli +6 more
TL;DR: Cette hypothese, formulee en 1961, annoncait la decouverte, plus recente, d’un mecanisme epigenetique plus general de regulation de l’expression de nombreux genes chez les mammiferes.
References
More filters
Journal ArticleDOI
Gene Action in the X -chromosome of the Mouse ( Mus musculus L.)
TL;DR: Ohno and Hauschka1 showed that in female mice one chromosome of mammary carcinoma cells and of normal diploid cells of the ovary, mammary gland and liver was heteropyKnotic and suggested that the so-called sex chromatin was composed of one heteropyknotic X-chromosome.
Journal ArticleDOI
Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification
Minjia Tan,Hao Luo,Sangkyu Lee,Fulai Jin,Jeong Soo Yang,Emilie Montellier,Thierry Buchou,Zhongyi Cheng,Sophie Rousseaux,Nisha Rajagopal,Zhike Lu,Zhen Ye,Qin Zhu,Joanna Wysocka,Yang Ye,Saadi Khochbin,Bing Ren,Yingming Zhao +17 more
TL;DR: The identification of 67 previously undescribed histone modifications is reported, increasing the current number of known histone marks by about 70%, and lysine crotonylation (Kcr) is investigated, confirming that it represents an evolutionarily-conserved histone posttranslational modification.
Journal ArticleDOI
Distinctive chromatin in human sperm packages genes for embryo development
Saher Sue Hammoud,David A. Nix,Haiying Zhang,Jahnvi Purwar,Douglas T. Carrell,Bradley R. Cairns +5 more
TL;DR: It is shown that the retained nucleosomes are significantly enriched at loci of developmental importance, including imprinted gene clusters, microRNA clusters, HOX genes clusters, and the promoters of stand-alone developmental transcription and signalling factors.
Journal ArticleDOI
Epigenetic dynamics of imprinted X inactivation during early mouse development.
TL;DR: It is shown that although initially active, the paternal X chromosome undergoes imprinted inactivation from the cleavage stages, well before cellular differentiation, which reveals the remarkable plasticity of the X-inactivation process during preimplantation development and underlines the importance of the ICM in global reprogramming of epigenetic marks in the early embryo.
Journal ArticleDOI
Xist-deficient mice are defective in dosage compensation but not spermatogenesis.
TL;DR: The results indicate that the Xist RNA is required for female dosage compensation but plays no role in spermatogenesis.