Lipogenesis and lipolysis: the pathways exploited by the cancer cells to acquire fatty acids.
Nousheen Zaidi,Leslie E. Lupien,Nancy B. Kuemmerle,William B. Kinlaw,Johannes V. Swinnen,Karine Smans +5 more
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TLDR
Recent reports indicate that lipolytically acquired FAs may provide an additional source of FAs for cancer, and current understanding of lipogenic and lipolytic pathways in cancer cell progression is focused on.About:
This article is published in Progress in Lipid Research.The article was published on 2013-10-01 and is currently open access. It has received 364 citations till now. The article focuses on the topics: Fatty acid synthesis & Lipogenesis.read more
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Decreased serum levels of glycerol-3- phosphate dehydrogenase 1 and monoacylglycerol lipase act as diagnostic biomarkers for breast cancer.
TL;DR: In this article, the diagnostic and prognostic values of glycerol-3phosphate dehydrogenase (GPD1) and monoacylglycerol lipase (MAGL) proteins as non-invasive serum biomarkers were evaluated.
Book ChapterDOI
Disturbances of Lipid Metabolism in a Cancer Cell and How This Knowledge Increases Its Role in Clinical Oncology
TL;DR: This data indicates that suppression of cytokine signaling-3 inoters is a major cause of nonalcoholic fatty liver disease and the target of rapamycin is likely to be a poorly understood “spatially aggregating force”.
Journal ArticleDOI
Progressive and Prognosis Role of Lipogenic Pathway in Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis
TL;DR: It is concluded that lipogenic pathway activation plays an important role in HCC development and prognosis.
Journal ArticleDOI
White adipose tissue-derived factors and prostate cancer progression: mechanisms and targets for interventions
TL;DR: A greater understanding of the impact of WAT in obesity-induced progression of PCa and the underlying mechanisms has begun to provide opportunities for developing interventional strategies for preventing or offsetting these critical events.
Proceedings ArticleDOI
A Framework for Route Based Pathway Analysis of Gene Expression Data
TL;DR: In this article, a novel route-based pathway analysis framework, Route based Pathway Analysis in Cohorts (rPAC), is discussed in which uses pathway topology in true sense by identifying and scoring individual routes within pathways.
References
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Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
TL;DR: It is proposed that the metabolism of cancer cells, and indeed all proliferating cells, is adapted to facilitate the uptake and incorporation of nutrients into the biomass needed to produce a new cell.
Journal ArticleDOI
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
Javier A. Menendez,Ruth Lupu +1 more
TL;DR: FASN, a nearly-universal druggable target in many human carcinomas and their precursor lesions, offers new therapeutic opportunities for metabolically treating and preventing cancer.
Journal ArticleDOI
PI3K pathway alterations in cancer: variations on a theme
TL Yuan,Lewis C. Cantley +1 more
TL;DR: The high frequency of phosphoinositide 3-kinase (PI3K) pathway alterations in cancer has led to a surge in the development of PI3K inhibitors and proposed treatment strategies tailored for these genetic lesions are proposed.
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Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
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