Lipogenesis and lipolysis: the pathways exploited by the cancer cells to acquire fatty acids.
Nousheen Zaidi,Leslie E. Lupien,Nancy B. Kuemmerle,William B. Kinlaw,Johannes V. Swinnen,Karine Smans +5 more
Reads0
Chats0
TLDR
Recent reports indicate that lipolytically acquired FAs may provide an additional source of FAs for cancer, and current understanding of lipogenic and lipolytic pathways in cancer cell progression is focused on.About:
This article is published in Progress in Lipid Research.The article was published on 2013-10-01 and is currently open access. It has received 364 citations till now. The article focuses on the topics: Fatty acid synthesis & Lipogenesis.read more
Citations
More filters
Journal ArticleDOI
Alpinetin delays high-fat diet-aggravated lung carcinogenesis.
TL;DR: Results demonstrate that ALP suppresses HFD‐promoted harmful changes in tumour microenvironments which are crucial in curbing pulmonary tumour aggravation.
Book ChapterDOI
Lipid Metabolism in Cancer Cells.
TL;DR: In this article, a review of the regulation, functions, and therapeutic benefits of targeting lipid metabolism in cancer cells is presented, highlighting the significance of exploring more potential therapeutic strategies for malignant diseases by unscrambling lipid metabolism regulation.
Journal ArticleDOI
A high extra-virgin olive oil diet induces changes in metabolic pathways of experimental mammary tumors.
Maite Garcia-Guasch,Lourdes Navarro,Vanessa Rivero,Irmgard Costa,Eduard Escrich,Raquel Moral +5 more
TL;DR: In this paper, the influence of high fat diets (rich in corn oil or extra virgin olive oil -EVOO-) and the timing of dietary intervention (from weaning or after induction) on tumor metabolism in a seven,12-dimethylbenz[a]anthracene (DMBA)-induced breast cancer model in rat was investigated.
Journal ArticleDOI
A bioinformatics investigation into the pharmacological mechanisms of javanica oil emulsion injection in non-small cell lung cancer based on network pharmacology methodologies.
Mengwei Ni,Xinkui Liu,Ziqi Meng,Shuyu Liu,Shanshan Jia,Yingying Liu,Wei Zhou,Jiarui Wu,Jingyuan Zhang,Siyu Guo,Jialin Li,Haojia Wang,Xiaomeng Zhang +12 more
TL;DR: This study predicted and verified that the mechanism of JOEI against NSCLC involves multiple targets and signaling pathways, and provides candidate targets for the treatment of NSclC, lays a good foundation for further experimental research and promotes the reasonable application of JoeI in clinical treatment.
Role of resveratrol metabolites in adipose function
TL;DR: A review of the literature of Northern Ireland finds that the country has changed little in the past 150 years, although its literature has changed significantly in the last century.
References
More filters
Journal ArticleDOI
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
TL;DR: It is proposed that the metabolism of cancer cells, and indeed all proliferating cells, is adapted to facilitate the uptake and incorporation of nutrients into the biomass needed to produce a new cell.
Journal ArticleDOI
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
Javier A. Menendez,Ruth Lupu +1 more
TL;DR: FASN, a nearly-universal druggable target in many human carcinomas and their precursor lesions, offers new therapeutic opportunities for metabolically treating and preventing cancer.
Journal ArticleDOI
PI3K pathway alterations in cancer: variations on a theme
TL Yuan,Lewis C. Cantley +1 more
TL;DR: The high frequency of phosphoinositide 3-kinase (PI3K) pathway alterations in cancer has led to a surge in the development of PI3K inhibitors and proposed treatment strategies tailored for these genetic lesions are proposed.
Related Papers (5)
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
Javier A. Menendez,Ruth Lupu +1 more