Lipogenesis and lipolysis: the pathways exploited by the cancer cells to acquire fatty acids.
Nousheen Zaidi,Leslie E. Lupien,Nancy B. Kuemmerle,William B. Kinlaw,Johannes V. Swinnen,Karine Smans +5 more
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TLDR
Recent reports indicate that lipolytically acquired FAs may provide an additional source of FAs for cancer, and current understanding of lipogenic and lipolytic pathways in cancer cell progression is focused on.About:
This article is published in Progress in Lipid Research.The article was published on 2013-10-01 and is currently open access. It has received 364 citations till now. The article focuses on the topics: Fatty acid synthesis & Lipogenesis.read more
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Matrix-Assisted Laser Desorption/Ionisation Mass Spectrometry Imaging in the Study of Gastric Cancer: A Mini Review
Andrew Smith,Isabella Piga,Manuel Galli,Martina Stella,Vanna Denti,Marina Del Puppo,Fulvio Magni +6 more
TL;DR: The state of the art of MALDI-MSI approaches are reported, ranging from sample preparation to statistical analysis, and a complete review of the key findings that have been reported in the literature thus far are provided.
Journal ArticleDOI
Unravelling the role of fatty acid metabolism in cancer through the FOXO3-FOXM1 axis
TL;DR: The role of FA metabolism in cancer and how FA metabolism integrates with the FOXO3-FOXM1 axis is discussed, which may provide leads to better cancer diagnostics as well as strategies for tackling cancer development, progression and drug resistance.
Journal ArticleDOI
Metabolic alterations and vulnerabilities in hepatocellular carcinoma
TL;DR: The current literature in HCC metabolic alterations, induced vulnerabilities, and potential therapeutic interventions are summarized to allow diagnostic and therapeutic advancements in the treatment of HCC.
Journal ArticleDOI
Autophagy activation and SREBP-1 induction contribute to fatty acid metabolic reprogramming by leptin in breast cancer cells
TL;DR: A crucial role of autophagy is highlighted in leptin‐induced cancer cell‐specific metabolism, which is mediated, at least in part, via SREBP‐1 induction.
Journal ArticleDOI
Rewiring of Lipid Metabolism and Storage in Ovarian Cancer Cells after Anti-VEGF Therapy.
Matteo Curtarello,Martina Tognon,Carolina Venturoli,Micol Silic-Benussi,Angela Grassi,Martina Verza,Sonia Minuzzo,Marica Pinazza,Valentina Brillo,Giovanni Tosi,Ruggero Ferrazza,Graziano Guella,Egidio Iorio,Adrien Godfroid,Nor Eddine Sounni,Alberto Amadori,Stefano Indraccolo +16 more
TL;DR: This multi-level analysis indicates alterations of lipid metabolism following anti-VEGF therapy in ovarian cancer xenografts and suggests that LXR-agonists might empower anti-tumor effects of bevacizumab.
References
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Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
TL;DR: It is proposed that the metabolism of cancer cells, and indeed all proliferating cells, is adapted to facilitate the uptake and incorporation of nutrients into the biomass needed to produce a new cell.
Journal ArticleDOI
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
Javier A. Menendez,Ruth Lupu +1 more
TL;DR: FASN, a nearly-universal druggable target in many human carcinomas and their precursor lesions, offers new therapeutic opportunities for metabolically treating and preventing cancer.
Journal ArticleDOI
PI3K pathway alterations in cancer: variations on a theme
TL Yuan,Lewis C. Cantley +1 more
TL;DR: The high frequency of phosphoinositide 3-kinase (PI3K) pathway alterations in cancer has led to a surge in the development of PI3K inhibitors and proposed treatment strategies tailored for these genetic lesions are proposed.
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