Lipogenesis and lipolysis: the pathways exploited by the cancer cells to acquire fatty acids.
Nousheen Zaidi,Leslie E. Lupien,Nancy B. Kuemmerle,William B. Kinlaw,Johannes V. Swinnen,Karine Smans +5 more
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TLDR
Recent reports indicate that lipolytically acquired FAs may provide an additional source of FAs for cancer, and current understanding of lipogenic and lipolytic pathways in cancer cell progression is focused on.About:
This article is published in Progress in Lipid Research.The article was published on 2013-10-01 and is currently open access. It has received 364 citations till now. The article focuses on the topics: Fatty acid synthesis & Lipogenesis.read more
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Resveratrol Inhibits Proliferation and Induces Autophagy by Blocking SREBP1 Expression in Oral Cancer Cells
TL;DR: Wang et al. as discussed by the authors found that resveratrol significantly reduced cell viability and induced autophagic cell death in oral cancer cells, but not in normal cells, which indicated a novel mechanism of the anti-cancer effect.
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Obesity promotes lipid accumulation in lymph node metastasis of gastric cancer: a retrospective case‒control study
Jian Xiao,Kuan Shen,Kanghui Liu,Yuan Wang,Hao Fan,Q F Cheng,Xinyi Zhou,Liyu Hu,Gang Wang,Zekuan Xu,Li Yang +10 more
TL;DR: In this paper , the association between obesity, lipid accumulation, and lymph node metastasis (LNM) in gastric cancer was investigated by calculating the odds ratio and 95% confidence interval (CI) in 1,058 eligible GC patients.
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The role of visfatin and resistin in an in vitro model of obesity-induced invasive liver cancer.
TL;DR: This article found that obesity is associated with the development of liver disease and its progression to hepatocellular carcinoma, which may be attributed to adipocytokines such as visfatin and resistin which have b...
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A high extra-virgin olive oil diet induces changes in metabolic pathways of experimental mammary tumors
TL;DR: In this paper , the influence of high fat diets (rich in corn oil or extra virgin olive oil -EVOO-) and the timing of dietary intervention (from weaning or after induction) on tumor metabolism in a seven,12-dimethylbenz[a]anthracene (DMBA)-induced breast cancer model in rat was investigated.
References
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Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
TL;DR: It is proposed that the metabolism of cancer cells, and indeed all proliferating cells, is adapted to facilitate the uptake and incorporation of nutrients into the biomass needed to produce a new cell.
Journal ArticleDOI
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
Javier A. Menendez,Ruth Lupu +1 more
TL;DR: FASN, a nearly-universal druggable target in many human carcinomas and their precursor lesions, offers new therapeutic opportunities for metabolically treating and preventing cancer.
Journal ArticleDOI
PI3K pathway alterations in cancer: variations on a theme
TL Yuan,Lewis C. Cantley +1 more
TL;DR: The high frequency of phosphoinositide 3-kinase (PI3K) pathway alterations in cancer has led to a surge in the development of PI3K inhibitors and proposed treatment strategies tailored for these genetic lesions are proposed.
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