Lipogenesis and lipolysis: the pathways exploited by the cancer cells to acquire fatty acids.
Nousheen Zaidi,Leslie E. Lupien,Nancy B. Kuemmerle,William B. Kinlaw,Johannes V. Swinnen,Karine Smans +5 more
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TLDR
Recent reports indicate that lipolytically acquired FAs may provide an additional source of FAs for cancer, and current understanding of lipogenic and lipolytic pathways in cancer cell progression is focused on.About:
This article is published in Progress in Lipid Research.The article was published on 2013-10-01 and is currently open access. It has received 364 citations till now. The article focuses on the topics: Fatty acid synthesis & Lipogenesis.read more
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Bypassing the Δ6-desaturase enzyme and directly providing n-3 and n-6 PUFA pathway intermediates reduces the survival of two human breast cancer cell lines
Howe-Ming Yu,Marnie Newell,Kalpana Subedi,Randall J. Weselake,Vera C. Mazurak,Catherine J. Field +5 more
TL;DR: The findings suggest that the less studied n-6 (GLA and DGLA) and n-3 (SDA and ETA) fatty acids could serve as alternative dietary sources of bioactive lipids targeted at breast cancer.
Journal ArticleDOI
Imaging of cancer lipid metabolism in response to therapy.
Sean P. Arlauckas,Sean P. Arlauckas,Elizabeth Anne Browning,Harish Poptani,Edward J. Delikatny +4 more
TL;DR: The understanding of lipid metabolism in response to cancer therapy continues to evolve as each therapeutic method emerges, and this review seeks to summarize the current field and areas of unmet needs.
Book ChapterDOI
Metabolism in the Tumor Microenvironment.
TL;DR: This chapter overviews the canonical metabolic alterations of tumor and stroma cells and to present specific examples of metabolic competition and symbiosis and some innovative solutions to investigate the clinical relevance of metabolic alterations for patient management and treatment.
Journal ArticleDOI
Renal Cell Cancer and Obesity
TL;DR: This review focuses on the impact of obesity on the risk of renal cancers development, their aggressiveness and patients’ survival.
Journal ArticleDOI
Animal models of well-differentiated/dedifferentiated liposarcoma: utility and limitations.
Silvia Codenotti,Walaa Mansoury,Luca Pinardi,Eugenio Monti,Francesco Marampon,Alessandro Fanzani +5 more
TL;DR: The xenograft and transgenic animal models generated for studying progression of well-differentiated and dedifferentiated liposarcoma are discussed, highlighting utilities and pitfalls in such approaches that can facilitate or impede the development of new therapies.
References
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Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
TL;DR: It is proposed that the metabolism of cancer cells, and indeed all proliferating cells, is adapted to facilitate the uptake and incorporation of nutrients into the biomass needed to produce a new cell.
Journal ArticleDOI
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
Javier A. Menendez,Ruth Lupu +1 more
TL;DR: FASN, a nearly-universal druggable target in many human carcinomas and their precursor lesions, offers new therapeutic opportunities for metabolically treating and preventing cancer.
Journal ArticleDOI
PI3K pathway alterations in cancer: variations on a theme
TL Yuan,Lewis C. Cantley +1 more
TL;DR: The high frequency of phosphoinositide 3-kinase (PI3K) pathway alterations in cancer has led to a surge in the development of PI3K inhibitors and proposed treatment strategies tailored for these genetic lesions are proposed.
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Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
Javier A. Menendez,Ruth Lupu +1 more