Local co-administration of gene-silencing RNA and drugs in cancer therapy: State-of-the art and therapeutic potential
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TLDR
It is concluded that advanced delivery systems for local administration of gene-silencing RNA and drug hold potential in treatment of cancer, depending on indication.About:
This article is published in Cancer Treatment Reviews.The article was published on 2017-04-01 and is currently open access. It has received 22 citations till now. The article focuses on the topics: Combination cancer therapy & Targeted drug delivery.read more
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Current Trends and Challenges in the Clinical Translation of Nanoparticulate Nanomedicines: Pathways for Translational Development and Commercialization
Susan Hua,Maria B.C. de Matos,Josbert M. Metselaar,Josbert M. Metselaar,Gert Storm,Gert Storm,Gert Storm +6 more
TL;DR: Key issues related to the clinical development of NNMs will be covered, including biological challenges, large-scale manufacturing, biocompatibility and safety, intellectual property (IP), government regulations, and overall cost-effectiveness in comparison to current therapies.
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Biopolymers for Antitumor Implantable Drug Delivery Systems: Recent Advances and Future Outlook
Sepehr Talebian,Sepehr Talebian,Javad Foroughi,Javad Foroughi,Samantha J. Wade,Samantha J. Wade,Kara L. Vine,Kara L. Vine,Alireza Dolatshahi-Pirouz,Mehdi Mehrali,João Conde,Gordon G. Wallace +11 more
TL;DR: The most recent advances in biopolymer‐based DDSs for suppressing tumor growth and preventing tumor recurrence are reviewed and a new therapeutic modality within the field, based on implantable biopolymeric D DSs, is given.
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Overcoming barriers by local drug delivery with liposomes
Sophia G. Antimisiaris,Sophia G. Antimisiaris,A. Marazioti,M. Kannavou,M. Kannavou,E. Natsaridis,E. Natsaridis,F. Gkartziou,G. Kogkos,G. Kogkos,Spyridon Mourtas +10 more
TL;DR: In this article, the most advanced cases of localized delivery of liposomal formulations of drugs, which have been investigated pre-clinically and clinically in the last ten years, together with the reported therapeutic advantages, in each case.
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Gene Therapy in Cancer Treatment: Why Go Nano?
TL;DR: The current trends on the use of nanoparticles designed for cancer gene therapy, including inorganic, organic, or biological variants, in clinical development and their progress towards clinical applications are reviewed.
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Alginate‐based complex fibers with the Janus morphology for controlled release of co‐delivered drugs
TL;DR: Along with their negligible toxicity and the retention of the activity of the loaded drugs, the complex fibers reported in this study warrant further development and optimization for applications that involve co-delivery of multiple agents.
References
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Marco Gerlinger,Andrew Rowan,Stuart Horswell,James Larkin,David Endesfelder,Eva Grönroos,Pierre Martinez,Nicholas Matthews,Aengus Stewart,Patrick S. Tarpey,Ignacio Varela,Benjamin Phillimore,Sharmin Begum,Neil Q. McDonald,Adam Butler,David T. Jones,Keiran Raine,Calli Latimer,Claudio R. Santos,Mahrokh Nohadani,Aron Charles Eklund,Bradley Spencer-Dene,Graham Clark,Lisa Pickering,Gordon Stamp,Martin Gore,Zoltan Szallasi,Zoltan Szallasi,Julian Downward,P. Andrew Futreal,Charles Swanton +30 more
TL;DR: Intratumor heterogeneity can lead to underestimation of the tumor genomics landscape portrayed from single tumor-biopsy samples and may present major challenges to personalized-medicine and biomarker development.
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Engineered Nanoparticles for Drug Delivery in Cancer Therapy
TL;DR: It is anticipated that precisely engineered nanoparticles will emerge as the next-generation platform for cancer therapy and many other biomedical applications.
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Injectable hydrogels as unique biomedical materials
Lin Yu,Jiandong Ding +1 more
TL;DR: This tutorial review summarizes and comments on this soft matter, especially thermogelling poly(ethylene glycol)-(biodegradable polyester) block copolymers, including both physical gels and chemical gels.
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Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets
Priscilla K. Brastianos,Scott L. Carter,Scott L. Carter,Sandro Santagata,Sandro Santagata,Daniel P. Cahill,Amaro Taylor-Weiner,Robert T. Jones,Eliezer M. Van Allen,Eliezer M. Van Allen,Michael S. Lawrence,Peleg M. Horowitz,Kristian Cibulskis,Keith L. Ligon,Keith L. Ligon,Josep Tabernero,Joan Seoane,Elena Martínez-Sáez,William T. Curry,Ian F. Dunn,Sun Ha Paek,Sung Hye Park,Aaron McKenna,Aaron Chevalier,Mara Rosenberg,Fred G. Barker,Corey M. Gill,Paul Van Hummelen,Aaron R. Thorner,Bruce E. Johnson,Mai P. Hoang,Toni K. Choueiri,Sabina Signoretti,Carrie Sougnez,Michael S. Rabin,Nan Lin,Eric P. Winer,Anat Stemmer-Rachamimov,Matthew Meyerson,Levi A. Garraway,Levi A. Garraway,Stacey Gabriel,Eric S. Lander,Rameen Beroukhim,Rameen Beroukhim,Tracy T. Batchelor,José Baselga,David N. Louis,Gad Getz,Gad Getz,William C. Hahn,William C. Hahn +51 more
TL;DR: Stricker et al. as discussed by the authors performed whole-exome sequencing of 86 matched brain metastases, primary tumors, and normal tissue and found potentially clinically informative alterations in the brain metastasis not detected in the matched primary-tumor sample.
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Biodegradable injectable in situ forming drug delivery systems
TL;DR: The various strategies that have been used to prepare in situ setting systems are introduced, and their advantages and disadvantages as localized drug delivery systems are outlined.