Recent progress in development of siRNA delivery vehicles for cancer therapy
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TLDR
The current status of clinical trials related to siRNA-based cancer therapy is described, as well as the remaining issues that need to be overcome to establish a successful therapy, and various promising design strategies of delivery vehicles for stable and targeted siRNA delivery are introduced.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2016-09-01 and is currently open access. It has received 329 citations till now. The article focuses on the topics: Small interfering RNA.read more
Citations
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Block Copolymer Micelles in Nanomedicine Applications.
TL;DR: By shaping these features, polymeric micelles have been propitious for delivering a wide range of therapeutics through effective sensing of targets in the body and adjustment of their properties in response to particular stimuli, modulating the activity of the loaded drugs at the targeted sites, even at the subcellular level.
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Current Trends and Challenges in the Clinical Translation of Nanoparticulate Nanomedicines: Pathways for Translational Development and Commercialization
Susan Hua,Maria B.C. de Matos,Josbert M. Metselaar,Josbert M. Metselaar,Gert Storm,Gert Storm,Gert Storm +6 more
TL;DR: Key issues related to the clinical development of NNMs will be covered, including biological challenges, large-scale manufacturing, biocompatibility and safety, intellectual property (IP), government regulations, and overall cost-effectiveness in comparison to current therapies.
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Gold nanoparticle-mediated photothermal therapy: applications and opportunities for multimodal cancer treatment.
Rachel S. Riley,Emily S. Day +1 more
TL;DR: Benefits of combining gold nanoparticle-mediated PTT with other treatment strategies can enhance the therapeutic success of both PTT and the secondary treatment while lowering the required doses of the individual agents, leading to fewer off-target effects.
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Long Noncoding RNA (lncRNA)-Mediated Competing Endogenous RNA Networks Provide Novel Potential Biomarkers and Therapeutic Targets for Colorectal Cancer
TL;DR: The competitive crosstalk among RNA transcripts and the novel targets for CRC prognosis and therapy are comprehensively discussed.
A Nanoparticle Size Series for In Vivo Fluorescence Imaging
Zoran B. Popović,Wenhao Liu,Vikash P. Chauhan,Jungmin Lee,Cliff Wong,Andrew B. Greytak,Numpon Insin,Daniel G. Nocera,Dai Fukumura,Rakesh K. Jain,Moungi G. Bawendi +10 more
TL;DR: Any design of nanoparticle vectors for cancer therapy or imaging must take into account the interaction of the nanoparticles with the tumor microenvironment, and size, charge, and shape have been shown to dominate this interaction.
References
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Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
Andrew Fire,SiQun Xu,Mary K. Montgomery,Steven A. Kostas,Steven A. Kostas,Samuel E. Driver,Craig C. Mello +6 more
TL;DR: To their surprise, it was found that double-stranded RNA was substantially more effective at producing interference than was either strand individually, arguing against stochiometric interference with endogenous mRNA and suggesting that there could be a catalytic or amplification component in the interference process.
Journal Article
A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs
Yasuhiro Matsumura,Hiroshi Maeda +1 more
TL;DR: It is speculated that the tumoritropic accumulation of smancs and other proteins resulted because of the hypervasculature, an enhanced permeability to even macromolecules, and little recovery through either blood vessels or lymphatic vessels in tumors of tumor-bearing mice.
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Microenvironmental regulation of tumor progression and metastasis.
TL;DR: The paradoxical roles of the tumor microenvironment during specific stages of cancer progression and metastasis are discussed, as well as recent therapeutic attempts to re-educate stromal cells within the TME to have anti-tumorigenic effects.
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Matrix Metalloproteinases: Regulators of the Tumor Microenvironment
TL;DR: In addition to their role in extracellular matrix turnover and cancer cell migration, MMPs regulate signaling pathways that control cell growth, inflammation, or angiogenesis and may even work in a nonproteolytic manner.
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Renal clearance of quantum dots.
Hak Soo Choi,Wenhao Liu,Preeti Misra,Eiichi Tanaka,John P. Zimmer,Binil Itty Ipe,Moungi G. Bawendi,John V. Frangioni,John V. Frangioni +8 more
TL;DR: This study has precisely defined the requirements for renal filtration and urinary excretion of inorganic, metal-containing nanoparticles and provides a foundation for the design and development of biologically targeted nanoparticles for biomedical applications.