Open AccessJournal Article
Local drug and gene delivery through microbubbles and ultrasound
Lynda J. M. Juffermans,Pieter A. Dijkmans,René J. P. Musters,A. van Wamel,Ayache Bouakaz,F. J. Ten Cate,Leo E. Deelman,Cees A. Visser,N. de Jong,O. (Otto) Kamp +9 more
TLDR
This review will give an overview of the viral and nonviral vehicles used for drug and gene delivery, and the different nonViral delivery techniques, thereby focusing on delivery through ultrasound contrast agents.Abstract:
Although gene therapy has great potential as a treatment for diseases, clinical trials are slowed down by the development of a safe and efficient gene delivery system. In this review, we will give an overview of the viral and nonviral vehicles used for drug and gene delivery, and the different nonviral delivery techniques, thereby focusing on delivery through ultrasound contrast agents. The development of ultrasound contrast agents containing encapsulated microbubbles has increased the possibilities not only for diagnostic imaging, but for therapy as well. Microbubbles have been shown to be able to carry drugs and genes, and destruction of the bubbles by ultrasound will result in local release of their contents. Furthermore, ligands can be attached so that they can be targeted to a specific target tissue. The recent advances of microbubbles as vehicles for delivery of drugs and genes will be highlighted.read more
Citations
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Oil-filled polymer microcapsules for ultrasound-mediated delivery of lipophilic drugs.
Klazina Kooiman,Marcel Rene Bohmer,M. Emmer,Hendrik J. Vos,Ceciel Chlon,William T. Shi,Christopher S. Hall,Suzanne H.P.M. de Winter,Karin Schroën,Michel Versluis,Nico de Jong,Nico de Jong,Annemieke van Wamel +12 more
TL;DR: The partially oil-filled microcapsules with high drug loads and well-defined acoustic activation thresholds have great potential for ultrasound-triggered local delivery of lipophilic drugs under ultrasound image-guidance.
Journal ArticleDOI
New chitosan nanobubbles for ultrasound-mediated gene delivery: preparation and in vitro characterization
Roberta Cavalli,Agnese Bisazza,Michele Trotta,Monica Argenziano,Andrea Civra,Manuela Donalisio,David Lembo +6 more
TL;DR: Chitosan nanobubbles have the potential to be promising tools for ultrasound-mediated DNA delivery and cell viability experiments demonstrated that neither ultrasound nor the nanobUBbles affected cell viability under these experimental conditions.
Journal ArticleDOI
Oxygen supersaturated fluid using fine micro/nanobubbles
TL;DR: The use of OFMNB-containing fluids is a potentially effective novel method for improving blood oxygenation in cases involving hypoxia, ischemic diseases, infection control, and anticancer chemoradiation therapies.
Journal ArticleDOI
Oxygen-Carrying Micro/Nanobubbles: Composition, Synthesis Techniques and Potential Prospects in Photo-Triggered Theranostics
Muhammad Saad Khan,Jangsun Hwang,Kyungwoo Lee,Yonghyun Choi,Kyobum Kim,Hyung-Jun Koo,Jong Wook Hong,Jonghoon Choi +7 more
TL;DR: Methods of functionalization of MNBs, their ability to deliver oxygen and drugs, incorporation of photosensitizers and potential application of photo-triggered theranostics, have also been discussed.
Journal ArticleDOI
Blood oxygenation using microbubble suspensions
Noriaki Matsuki,Shingo Ichiba,Takuji Ishikawa,Osamu Nagano,Motohiro Takeda,Yoshihito Ujike,Takami Yamaguchi +6 more
TL;DR: It is demonstrated that nano or microbubbles can achieve oxygen supersaturation of fluids, and may be sufficiently small and safe for infusion into blood vessels, and NSS is suitable for production of oxygen-rich fluid.
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