Journal ArticleDOI
Long-term persistence of SARS-CoV-2 neutralizing antibody responses after infection and estimates of the duration of protection.
Eric H. Y. Lau,David S Hui,Owen Tak-Yin Tsang,WY Chan,Mike Ye Kwan,Susan S. Chiu,Samuel Ms Cheng,Ronald L.W. Ko,John Kc Li,Sara Chaothai,Chi H. Tsang,Leo L.M. Poon,J. S. Malik Peiris +12 more
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TLDR
There will be relatively long-lived protection from re-infection following symptomatic COVID-19 disease, and there was a high level of correlation between PRNT50 antibody titers and the % of inhibition in surrogate virus neutralization tests.About:
This article is published in EClinicalMedicine.The article was published on 2021-10-30. It has received 48 citations till now. The article focuses on the topics: Antibody titer & Neutralizing antibody.read more
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Neutralizing antibodies against the SARS-CoV-2 Omicron variant BA.1 following homologous and heterologous CoronaVac or BNT162b2 vaccination
Samuel M.S. Cheng,Chris Ka Pun Mok,Yonna W.Y. Leung,Susanna S.S. Ng,Karl C. K. Chan,Fanny W.S. Ko,Chunke Chen,Karen Yiu,Bosco Hoi-Shiu Lam,Eric H. Y. Lau,Ken K. P. Chan,L. Luk,John Kc Li,L. Tsang,Leo L.M. Poon,David S.C. Hui,Malik Peiris +16 more
TL;DR: In this paper , the authors showed that a 50% plaque reduction neutralization antibody titer (PRNT50) ≥ 25.6 in their live virus assay corresponded to the threshold for 50% protection from infection against wild-type (WT) SARS-CoV-2 Omicron variant.
Journal ArticleDOI
SARS-CoV-2 reinfections: Overview of efficacy and duration of natural and hybrid immunity
TL;DR: In this paper , a narrative review provides an overview on epidemiological studies addressing the issue of SARS-CoV-2 infection and the efficacy and duration of natural immunity in terms of protection against reinfections and severe disease.
Journal ArticleDOI
Gut microbiota composition is associated with SARS-CoV-2 vaccine immunogenicity and adverse events
Siew C. Ng,Ye Peng,Lin Zhang,Chris Kp Mok,Shilin Zhao,Amy Li,Jessica Y.L. Ching,Yingzhi Liu,Shuai Yan,Dream L S Chan,Jie Zhu,Chunke Chen,Adrian Ch Fung,Kenneth KY Wong,David S.C. Hui,Francis K.L. Chan,Hein M. Tun +16 more
TL;DR: This study has identified specific gut microbiota markers in association with improved immune response and reduced adverse events following COVID-19 vaccines, indicating that microbiota-targeted interventions have the potential to complement effectiveness of CO VID-19 vaccine.
Journal ArticleDOI
Immunogenicity and reactogenicity of SARS-CoV-2 vaccines BNT162b2 and CoronaVac in healthy adolescents
Jaime S. Rosa Duque,Xiwei Wang,Daniel Leung,Samuel M.S. Cheng,Carolyn A Cohen,Xiao-ping Mu,Asmaa Hachim,Yanmei Zhang,S.-M. Chan,Sara Chaothai,K. Kwan,Karl C. K. Chan,John Kc Li,L. Luk,L. Tsang,Wilfred Hs Wong,Cheuk Hei Cheang,Timothy K Hung,J. H. Lam,Gilbert T. Chua,Winnie W.Y. Tso,Patrick Ip,Masashi Mori,Niloufar Kavian,Wing Hang Leung,Sophie A. Valkenburg,Malik Peiris,Wenwei Tu,Y.L. Lau +28 more
TL;DR: In this article , an interim analysis of a registered clinical study (NCT04800133) to establish immunobridging with various antibody and cellular immunity markers and to compare the immunogenicity and reactogenicity of 2-dose BNT162b2 and CoronaVac in healthy adolescents as primary objectives.
References
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Journal ArticleDOI
Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection.
David S. Khoury,Deborah Cromer,Arnold Reynaldi,Timothy E. Schlub,Timothy E. Schlub,Adam K. Wheatley,Jennifer A Juno,Kanta Subbarao,Stephen J. Kent,Stephen J. Kent,Stephen J. Kent,James A. Triccas,Miles P. Davenport +12 more
TL;DR: It is shown that neutralization level is highly predictive of immune protection, and an evidence-based model of SARS-CoV-2 immune protection that will assist in developing vaccine strategies to control the future trajectory of the pandemic is provided.
Journal ArticleDOI
Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection.
Jennifer M. Dan,Jennifer M. Dan,Jose Mateus,Yu Kato,Kathryn M. Hastie,Esther Dawen Yu,Caterina E. Faliti,Alba Grifoni,Sydney I. Ramirez,Sydney I. Ramirez,Sonya Haupt,April Frazier,Catherine Nakao,Vamseedhar Rayaprolu,Stephen A. Rawlings,Bjoern Peters,Bjoern Peters,Florian Krammer,Viviana Simon,Erica Ollmann Saphire,Erica Ollmann Saphire,Davey M. Smith,Daniela Weiskopf,Alessandro Sette,Alessandro Sette,Shane Crotty,Shane Crotty +26 more
TL;DR: This article analyzed multiple compartments of circulating immune memory to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 254 samples from 188 COVID-19 cases, including 43 samples at ≥ 6 months after infection.
Journal ArticleDOI
Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates.
Edward E. Walsh,Robert W. Frenck,Ann R. Falsey,Ann R. Falsey,Nicholas Kitchin,Judith Absalon,Alejandra Gurtman,Stephen Lockhart,Kathleen M. Neuzil,Mark J. Mulligan,Ruth Bailey,Kena A. Swanson,Ping Li,Kenneth Koury,Warren Kalina,David A. Cooper,Camila R. Fontes-Garfias,Pei Yong Shi,Özlem Türeci,Tompkins Kristin Rachael,Kirsten E. Lyke,Vanessa Raabe,Philip R. Dormitzer,Kathrin U. Jansen,Ugur Sahin,William C. Gruber +25 more
TL;DR: The safety and immunogenicity data from this U.S. phase 1 trial of two vaccine candidates in younger and older adults support the selection of BNT162b2 for advancement to a pivotal phase 2–3 safety and efficacy evaluation.
Journal ArticleDOI
Convergent antibody responses to SARS-CoV-2 in convalescent individuals.
Davide F. Robbiani,Davide F. Robbiani,Christian Gaebler,Frauke Muecksch,Julio C. C. Lorenzi,Zijun Wang,Alice Cho,Marianna Agudelo,Christopher O. Barnes,Anna Gazumyan,Shlomo Finkin,Thomas Hagglof,Thiago Y. Oliveira,Charlotte Viant,Arlene Hurley,Hans Heinrich Hoffmann,Katrina G. Millard,Rhonda G. Kost,Melissa Cipolla,Kristie Gordon,Filippo Bianchini,Spencer T. Chen,Victor A. Ramos,Roshni Patel,Juan Dizon,Irina Shimeliovich,Pilar Mendoza,Harald Hartweger,Lilian Nogueira,Maggi Pack,Jill Horowitz,Fabian Schmidt,Yiska Weisblum,Eleftherios Michailidis,Alison W. Ashbrook,Eric Waltari,John E. Pak,Kathryn E. Huey-Tubman,Nicholas Koranda,Pauline R. Hoffman,Anthony P. West,Charles M. Rice,Theodora Hatziioannou,Pamela J. Bjorkman,Paul D. Bieniasz,Paul D. Bieniasz,Marina Caskey,Michel C. Nussenzweig,Michel C. Nussenzweig +48 more
TL;DR: Most convalescent plasma samples obtained from individuals who recover from COVID-19 do not contain high levels of neutralizing activity, and rare but recurring RBD-specific antibodies with potent antiviral activity were found in all individuals tested, suggesting that a vaccine designed to elicit such antibodies could be broadly effective.
Journal ArticleDOI
SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls.
Nina Le Bert,Anthony T. Tan,Kamini Kunasegaran,Christine Y.L. Tham,Morteza Hafezi,Adeline Chia,Melissa Hui Yen Chng,Meiyin Lin,Meiyin Lin,Nicole Tan,Martin Linster,Wan Ni Chia,Mark I-Cheng Chen,Lin-Fa Wang,Eng Eong Ooi,Shirin Kalimuddin,Paul A. Tambyah,Jenny G. Low,Jenny G. Low,Yee-Joo Tan,Yee-Joo Tan,Antonio Bertoletti,Antonio Bertoletti +22 more
TL;DR: Infection with betacoronaviruses induces multi-specific and long-lasting T cell immunity against the structural N protein, and SARS-CoV-2-reactive T cells were found in individuals who had recovered from SARS or COVID-19 and in unexposed donors, although with different patterns of immunoreactivity.
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