MEROPS: the peptidase database
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TLDR
The MEROPS database has added an analysis tool to the relevant species pages to show significant gains and losses of peptidase genes relative to related species, and has collected over 39 000 known cleavage sites in proteins, peptides and synthetic substrates.Abstract:
Peptidases (proteolytic enzymes) are of great relevance to biology, medicine and biotechnology. This practical importance creates a need for an integrated source of information about them, and also about their natural inhibitors. The MEROPS database (http://merops.sanger.ac.uk) aims to fill this need. The organizational principle of the database is a hierarchical classification in which homologous sets of the proteins of interest are grouped in families and the homologous families are grouped in clans. Each peptidase, family and clan has a unique identifier. The database has recently been expanded to include the protein inhibitors of peptidases, and these are classified in much the same way as the peptidases. Forms of information recently added include new links to other databases, summary alignments for peptidase clans, displays to show the distribution of peptidases and inhibitors among organisms, substrate cleavage sites and indexes for expressed sequence tag libraries containing peptidases. A new way of making hyperlinks to the database has been devised and a BlastP search of our library of peptidase and inhibitor sequences has been added.read more
Citations
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The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling.
Ivan Bosanac,Henry R. Maun,Suzie J. Scales,Xiaohui Wen,Andreas Lingel,J. Fernando Bazan,Frederic J. de Sauvage,Sarah G. Hymowitz,Robert A. Lazarus +8 more
TL;DR: A role for Hhip is proposed as a structural decoy receptor for vertebrate Hh in the form of a 'patch for Patched' at the Shh pseudo active site.
Journal ArticleDOI
Genomic Characterization Reveals Insights Into Patulin Biosynthesis and Pathogenicity in Penicillium Species
Boqiang Li,Yuanyuan Zong,Zhenglin Du,Yong Chen,Zhanquan Zhang,Guozheng Qin,Wenming Zhao,Shiping Tian +7 more
TL;DR: The whole genome sequence of Penicillium expansum and P. italicum is provided and it is confirmed that PePatL and PePatK play crucial roles in the biosynthesis of patulin and that patulin production is not related to virulence of P. expansum.
Journal ArticleDOI
MSDmotif: exploring protein sites and motifs.
Adel Golovin,Kim Henrick +1 more
TL;DR: MSDmotif provides multiple views of data found in the PDB archive for exploring protein structures by combining chemical, sequence and 3D data in a single search engine with a range of search and visualisation options.
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Cross genome comparisons of serine proteases in Arabidopsis and rice.
TL;DR: The systematic analysis of the serine protease-like proteins in the two plant species has provided some insight into the possible functional associations of previously uncharacterised serine proteins.
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Microbial and fungal protease inhibitors—current and potential applications
Jerica Sabotič,Janko Kos +1 more
TL;DR: Proteolytic enzymes play essential metabolic and regulatory functions in many biological processes and also offer a wide range of biotechnological applications, so small molecules and proteins that inhibit proteases can be versatile tools in the fields of medicine, agriculture and biotechnology.
References
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