MEROPS: the peptidase database
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TLDR
The MEROPS database has added an analysis tool to the relevant species pages to show significant gains and losses of peptidase genes relative to related species, and has collected over 39 000 known cleavage sites in proteins, peptides and synthetic substrates.Abstract:
Peptidases (proteolytic enzymes) are of great relevance to biology, medicine and biotechnology. This practical importance creates a need for an integrated source of information about them, and also about their natural inhibitors. The MEROPS database (http://merops.sanger.ac.uk) aims to fill this need. The organizational principle of the database is a hierarchical classification in which homologous sets of the proteins of interest are grouped in families and the homologous families are grouped in clans. Each peptidase, family and clan has a unique identifier. The database has recently been expanded to include the protein inhibitors of peptidases, and these are classified in much the same way as the peptidases. Forms of information recently added include new links to other databases, summary alignments for peptidase clans, displays to show the distribution of peptidases and inhibitors among organisms, substrate cleavage sites and indexes for expressed sequence tag libraries containing peptidases. A new way of making hyperlinks to the database has been devised and a BlastP search of our library of peptidase and inhibitor sequences has been added.read more
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Patent
Factor viii compositions and methods of making and using same
Volker Schellenberger,Pei-Yun Chang,Varfaj Fatbardha,Sheng Ding,Joshua Silverman,Chia-Wei Wang,Benjamin Spink,Willem P. C. Stemmer,Nathan Geething,John Kulman,Tongyao Liu,Garabet G. Toby,Haiyan Jiang,Robert T. Peters,Wang Deping,Baisong Mei +15 more
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Journal ArticleDOI
Covalent assembly of nanoparticles as a peptidase-degradable platform for molecular MRI
Francisco Perez-Balderas,S I van Kasteren,Aljabali Aaa.,Aljabali Aaa.,Aljabali Aaa.,Kim Wals,Sébastien Serres,Andrew Jefferson,M Sarmiento Soto,Alexandre A. Khrapitchev,James R. Larkin,C Bristow,Seung Seo Lee,G Bort,F De Simone,Sandra J. Campbell,Robin P. Choudhury,Daniel C. Anthony,Nicola R. Sibson,Benjamin G. Davis +19 more
TL;DR: It is demonstrated that ligand-targeted MPIO derived from multiple iron oxide nanoparticles may be coupled covalently through peptide linkers that are designed to be cleaved by intracellular macrophage proteases and that the targeted probes can be used for detection of inflammation in vivo using MRI.
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A putative role for amino acid permeases in sink-source communication of barley tissues uncovered by RNA-seq
Stefan Kohl,Julien Hollmann,Frank R. Blattner,Volodymyr Radchuk,Franka Andersch,Burkhard Steuernagel,Thomas Schmutzer,Uwe Scholz,Karin Krupinska,Hans Weber,Winfriede Weschke +10 more
TL;DR: Transcriptome large-scale pyrosequencing of flag leaves, glumes and developing grains was used to identify cysteine peptidase and N transporter genes playing a role in remobilisation and accumulation of nitrogen in barley and identified new members of cystein peptidases and specific N transporters of the AAT family.
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The multiple functions of plant serine protease inhibitors: defense against herbivores and beyond.
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Insight into the core and variant exoproteomes of Listeria monocytogenes species by comparative subproteomic analysis.
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