MEROPS: the peptidase database
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TLDR
The MEROPS database has added an analysis tool to the relevant species pages to show significant gains and losses of peptidase genes relative to related species, and has collected over 39 000 known cleavage sites in proteins, peptides and synthetic substrates.Abstract:
Peptidases (proteolytic enzymes) are of great relevance to biology, medicine and biotechnology. This practical importance creates a need for an integrated source of information about them, and also about their natural inhibitors. The MEROPS database (http://merops.sanger.ac.uk) aims to fill this need. The organizational principle of the database is a hierarchical classification in which homologous sets of the proteins of interest are grouped in families and the homologous families are grouped in clans. Each peptidase, family and clan has a unique identifier. The database has recently been expanded to include the protein inhibitors of peptidases, and these are classified in much the same way as the peptidases. Forms of information recently added include new links to other databases, summary alignments for peptidase clans, displays to show the distribution of peptidases and inhibitors among organisms, substrate cleavage sites and indexes for expressed sequence tag libraries containing peptidases. A new way of making hyperlinks to the database has been devised and a BlastP search of our library of peptidase and inhibitor sequences has been added.read more
Citations
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Journal ArticleDOI
The MEROPS batch BLAST: a tool to detect peptidases and their non-peptidase homologues in a genome.
TL;DR: A tool is presented which not only performs a comparison against the MEROPS sequence collection, but also does a pair-wise alignment with the closest homologue detected and calculates the position of the active site residues.
Journal ArticleDOI
Virulence mechanisms of coccidioides.
TL;DR: It is proposed that ammonia and enzymatically active urease released from spherules during the parasitic cycle of Coccidioides exacerbate the severity of coccidioidal infection by contributing to a compromised immune response to infection and damage of host tissue at foci of infection.
Book ChapterDOI
The Role of Adams in Notch Signaling
Arjan J. Groot,Marc Vooijs +1 more
TL;DR: The role of ectodomain shedding is reviewed in RIP of the NOTCH signaling pathway, a highly conserved cell-cell communication pathway that mediates cell fate decisions during development and in adult tissues.
Journal ArticleDOI
The Protein Composition of the Digestive Fluid from the Venus Flytrap Sheds Light on Prey Digestion Mechanisms
Waltraud X. Schulze,Kristian W. Sanggaard,Ines Kreuzer,Anders Dahl Knudsen,Felix Bemm,Ida B. Thøgersen,Andrea Bräutigam,Line R. Thomsen,Simon Schliesky,Thomas F. Dyrlund,María Escalante-Pérez,Dirk Becker,Joerg Schultz,Henrik Karring,Andreas P.M. Weber,Peter Højrup,Rainer Hedrich,Rainer Hedrich,Jan J. Enghild +18 more
TL;DR: In-depth characterization of a highly specialized secreted fluid from a carnivorous plant provides new information about the plant's prey digestion mechanism and the evolutionary processes driving its defense pathways and nutrient acquisition.
Journal ArticleDOI
In Vitro Reconstitution and Substrate Specificity of a Lantibiotic Protease
TL;DR: The purification and in vitro activity of the N-terminal protease domain of LctT (LctT150) is reported, and its use for the in vitro production of lacticin 481 is reported.
References
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