MEROPS: the peptidase database
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TLDR
The MEROPS database has added an analysis tool to the relevant species pages to show significant gains and losses of peptidase genes relative to related species, and has collected over 39 000 known cleavage sites in proteins, peptides and synthetic substrates.Abstract:
Peptidases (proteolytic enzymes) are of great relevance to biology, medicine and biotechnology. This practical importance creates a need for an integrated source of information about them, and also about their natural inhibitors. The MEROPS database (http://merops.sanger.ac.uk) aims to fill this need. The organizational principle of the database is a hierarchical classification in which homologous sets of the proteins of interest are grouped in families and the homologous families are grouped in clans. Each peptidase, family and clan has a unique identifier. The database has recently been expanded to include the protein inhibitors of peptidases, and these are classified in much the same way as the peptidases. Forms of information recently added include new links to other databases, summary alignments for peptidase clans, displays to show the distribution of peptidases and inhibitors among organisms, substrate cleavage sites and indexes for expressed sequence tag libraries containing peptidases. A new way of making hyperlinks to the database has been devised and a BlastP search of our library of peptidase and inhibitor sequences has been added.read more
Citations
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Gene expression analysis of the murine model of amyotrophic lateral sclerosis: studies of the Leu126delTT mutation in SOD1.
Yasuyo Fukada,Kenichi Yasui,Michio Kitayama,Koji Doi,Toshiya Nakano,Yasuhiro Watanabe,Kenji Nakashima +6 more
TL;DR: Gen expression in the spinal cord of SOD1(L126delTT) TgM by cDNA microarray is analyzed and four genes may be related to the pathogenesis of FALS, especially with regard to the progression of reactive astrocytes and the inflammatory response of microglial cells.
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The Genome of Spironucleus salmonicida Highlights a Fish Pathogen Adapted to Fluctuating Environments
Feifei Xu,Jon Jerlström-Hultqvist,Elin Einarsson,Ásgeir Ástvaldsson,Staffan G. Svärd,Jan Andersson +5 more
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Ixodes scapularis tick serine proteinase inhibitor (serpin) gene family; annotation and transcriptional analysis.
TL;DR: This study provides insight on the potential sizes of serpin protein families in ticks and speculate that I. scapularis may utilize some of the serpins reported in this study to manipulate host defense.
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Comprehensive characterisation of the heterogeneity of adalimumab via charge variant analysis hyphenated on-line to native high resolution Orbitrap mass spectrometry
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Cathepsins and osteosarcoma: Expression analysis identifies cathepsin K as an indicator of metastasis.
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