MEROPS: the peptidase database
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TLDR
The MEROPS database has added an analysis tool to the relevant species pages to show significant gains and losses of peptidase genes relative to related species, and has collected over 39 000 known cleavage sites in proteins, peptides and synthetic substrates.Abstract:
Peptidases (proteolytic enzymes) are of great relevance to biology, medicine and biotechnology. This practical importance creates a need for an integrated source of information about them, and also about their natural inhibitors. The MEROPS database (http://merops.sanger.ac.uk) aims to fill this need. The organizational principle of the database is a hierarchical classification in which homologous sets of the proteins of interest are grouped in families and the homologous families are grouped in clans. Each peptidase, family and clan has a unique identifier. The database has recently been expanded to include the protein inhibitors of peptidases, and these are classified in much the same way as the peptidases. Forms of information recently added include new links to other databases, summary alignments for peptidase clans, displays to show the distribution of peptidases and inhibitors among organisms, substrate cleavage sites and indexes for expressed sequence tag libraries containing peptidases. A new way of making hyperlinks to the database has been devised and a BlastP search of our library of peptidase and inhibitor sequences has been added.read more
Citations
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Journal ArticleDOI
Gene discovery for the carcinogenic human liver fluke, Opisthorchis viverrini
Thewarach Laha,Porntip Pinlaor,Jason Mulvenna,Banchob Sripa,Manop Sripa,Michael J. Smout,Robin B. Gasser,Paul J. Brindley,Alex Loukas +8 more
TL;DR: An assessment of evolutionary relationships showed that O. viverrini was more similar to other parasitic species than to free-living flatworms, and 105 sequences had close homologues in both parasitic species but not in S. mediterranea.
Journal ArticleDOI
Selective inhibition of ADAMTS-1, -4 and -5 by catechin gallate esters.
Mireille Vankemmelbeke,Gavin C. Jones,Cyprianne Fowles,Mirna Z. Ilic,Christopher J. Handley,Anthony J. Day,C. Graham Knight,John S. Mort,David J. Buttle +8 more
TL;DR: Catechin gallate esters provide selective inhibition of certain members of the ADAMTS group of enzymes and could constitute an important nutritional aid in the prevention of arthritis as well as being part of an effective therapy in the treatment of joint disease and other pathologies involving the action of these enzymes.
Journal ArticleDOI
Genome-Wide Identification and Immune Response Analysis of Serine Protease Inhibitor Genes in the Silkworm, Bombyx mori
Ping Zhao,Zhaoming Dong,Jun Duan,Jun Duan,Genhong Wang,Genhong Wang,Lingyan Wang,Youshan Li,Zhonghuai Xiang,Qingyou Xia,Qingyou Xia +10 more
TL;DR: Results suggested that these SPI genes may be involved in resistance to pathogenic microorganisms, and may provide valuable information for further clarifying the roles of SPIs in the development, immune defence, and efficient synthesis of silk gland protein.
Journal ArticleDOI
Structure and mechanism of metallocarboxypeptidases.
TL;DR: In both cowrins and funnelins, substrate hydrolysis follows a common general base/acid mechanism, and a metal-bound solvent molecule ultimately performs the attack on the scissile peptide bond with the assistance of a strictly conserved glutamate residue.
References
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