Journal ArticleDOI
MicroRNA in prostate, bladder, and kidney cancer: a systematic review.
James W.F. Catto,Antonio Alcaraz,Anders Bjartell,Ralph W deVere White,Christopher P. Evans,Susanne Füssel,Freddie C. Hamdy,Olli Kallioniemi,Lourdes Mengual,Thorsten Schlomm,Tapio Visakorpi +10 more
TLDR
MiRNAs appear to be important modulators of urologic cancer, and many are functionally implicated in their pathogenesis.About:
This article is published in European Urology.The article was published on 2011-05-01. It has received 448 citations till now. The article focuses on the topics: Cancer & Gene silencing.read more
Citations
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MicroRNA-195-5p, a new regulator of Fra-1, suppresses the migration and invasion of prostate cancer cells
Jian Wu,Alin Ji,Xiao Wang,Yi Zhu,Yasai Yu,Yiwei Lin,Yunfu Liu,Shiqi Li,Zhen Liang,Xin Xu,Xiangyi Zheng,Liping Xie +11 more
TL;DR: The role of miR-195 in the development and progression of prostate cancer was investigated in this paper, where the authors showed that miR195 could be a tumor suppressor and may have a potential to be a diagnostics or therapeutic target in prostate cancer.
Journal ArticleDOI
Novel oncogenic function of mesoderm development candidate 1 and its regulation by MiR-574-3p in bladder cancer cell lines.
Shuichi Tatarano,Takeshi Chiyomaru,Kazumori Kawakami,Hideki Enokida,Hirofumi Yoshino,Hideo Hidaka,Nijiro Nohata,Takeshi Yamasaki,Takenari Gotanda,Tokushi Tachiwada,Naohiko Seki,Masayuki Nakagawa +11 more
TL;DR: It is demonstrated for the first time that miR-574-3p is a miRNA with tumor suppressor function and that MESDC1 (which has a potential oncogenic function in BC) may be targeted by miR -574- 3p.
Mechanisms of Androgen-Independent Prostate Cancer.
TL;DR: Understanding the molecular alterations that occur during this process will allow for improved therapeutic strategies to target key molecules and pathways important for this progression to androgen-independent prostate cancer.
Journal ArticleDOI
Long Non-Coding RNA TUG1 Promotes Proliferation and Inhibits Apoptosis of Osteosarcoma Cells by Sponging miR-132-3p and Upregulating SOX4 Expression.
TL;DR: TUG1 facilitated proliferation and suppressed apoptosis by regulating the miR-132-3p/SOX4 axis in human OS cell lines and primary OS cells, and provides a potential target for OS therapy.
Journal ArticleDOI
microRNA profiles in urine by next-generation sequencing can stratify bladder cancer subtypes.
Barbara Pardini,Francesca Cordero,Alessio Naccarati,Clara Viberti,Giovanni Birolo,Marco Oderda,Cornelia Di Gaetano,Maddalena Arigoni,Federica Martina,Raffaele A. Calogero,Carlotta Sacerdote,Paolo Gontero,Paolo Vineis,Giuseppe Matullo +13 more
TL;DR: In conclusions, the non-invasive detection in urine of a selected number of miRNAs altered in different BC subtypes could lead to an accurate early diagnosis of cancer and stratification of patients.
References
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Journal ArticleDOI
MicroRNAs: Target Recognition and Regulatory Functions
TL;DR: The current understanding of miRNA target recognition in animals is outlined and the widespread impact of miRNAs on both the expression and evolution of protein-coding genes is discussed.
Journal ArticleDOI
Circulating microRNAs as stable blood-based markers for cancer detection
Patrick S. Mitchell,Rachael K. Parkin,Evan M. Kroh,Brian R. Fritz,Brian R. Fritz,Stacia K. Wyman,Era L. Pogosova-Agadjanyan,Amelia Peterson,Jennifer Noteboom,Kathy O'Briant,April Allen,Daniel W. Lin,Daniel W. Lin,Daniel W. Lin,Nicole Urban,Charles W. Drescher,Beatrice S. Knudsen,Derek L. Stirewalt,Robert Gentleman,Robert L. Vessella,Robert L. Vessella,Peter S. Nelson,Daniel Martin,Daniel Martin,Muneesh Tewari +24 more
TL;DR: It is shown here that miRNAs are present in human plasma in a remarkably stable form that is protected from endogenous RNase activity and established the measurement of tumor-derived mi RNAs in serum or plasma as an important approach for the blood-based detection of human cancer.
Journal ArticleDOI
A microRNA polycistron as a potential human oncogene
Lin He,J. Michael Thomson,Michael T. Hemann,Eva Hernando-Monge,David Mu,Summer G. Goodson,Scott Powers,Carlos Cordon-Cardo,Scott W. Lowe,Gregory J. Hannon,Scott M. Hammond +10 more
TL;DR: It is found that the levels of the primary or mature microRNAs derived from the mir-17–92 locus are often substantially increased in human B-cell lymphomas, and the cluster is implicate as a potential human oncogene.
Mammalian microRNAs predominantly act to decrease target mRNA levels
Huili Guo,Nicholas T. Ingolia,Nicholas T. Ingolia,Jonathan S. Weissman,Jonathan S. Weissman,David P. Bartel +5 more
TL;DR: Results show that changes in mRNA levels closely reflect the impact of miRNAs on gene expression and indicate that destabilization of target mRNAs is the predominant reason for reduced protein output.
Journal ArticleDOI
Mammalian microRNAs predominantly act to decrease target mRNA levels
Huili Guo,Nicholas T. Ingolia,Nicholas T. Ingolia,Jonathan S. Weissman,Jonathan S. Weissman,David P. Bartel +5 more
TL;DR: In this paper, the authors used ribosome profiling to measure the overall effects on protein production and compare these to simultaneously measured effects on mRNA levels, showing that changes in mRNA levels closely reflect the impact of miRNAs on gene expression and indicate that destabilization of target mRNAs is the predominant reason for reduced protein output.
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Circulating microRNAs as stable blood-based markers for cancer detection
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