Journal ArticleDOI
MicroRNA in prostate, bladder, and kidney cancer: a systematic review.
James W.F. Catto,Antonio Alcaraz,Anders Bjartell,Ralph W deVere White,Christopher P. Evans,Susanne Füssel,Freddie C. Hamdy,Olli Kallioniemi,Lourdes Mengual,Thorsten Schlomm,Tapio Visakorpi +10 more
TLDR
MiRNAs appear to be important modulators of urologic cancer, and many are functionally implicated in their pathogenesis.About:
This article is published in European Urology.The article was published on 2011-05-01. It has received 448 citations till now. The article focuses on the topics: Cancer & Gene silencing.read more
Citations
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Journal ArticleDOI
An evaluation of urinary microRNA reveals a high sensitivity for bladder cancer
Saiful Miah,Ewa Dudziec,Ross M. Drayton,Alexandre R. Zlotta,Susan Morgan,Derek J. Rosario,Freddie C. Hamdy,James W.F. Catto +7 more
TL;DR: It is found that miR is stable within urinary cells despite adverse handling and detected differential expression of 10 miRs from patients with cancer and controls, and this panel in patients with haematuria would have found 94% of urothelial cell carcinoma, while reducing cystoscopy rates by 26%.
Journal ArticleDOI
MicroRNA-106b-25 cluster expression is associated with early disease recurrence and targets caspase-7 and focal adhesion in human prostate cancer.
Robert S. Hudson,Ming Yi,Dominic Esposito,Sharon A. Glynn,Adrienne M. Starks,Yinmeng Yang,Aaron J. Schetter,Stephanie K. Watkins,Arthur A. Hurwitz,Tiffany H. Dorsey,Robert M. Stephens,Carlo M. Croce,Stefan Ambs +12 more
TL;DR: The miR-106b-25 microRNA (miRNA) cluster is a candidate oncogene in human prostate cancer as discussed by the authors and miRNAs encoded by miR106b25 are upregulated in both primary tumors and distant metastasis.
Journal ArticleDOI
Bladder Cancer Detection and Monitoring: Assessment of Urine- and Blood-Based Marker Tests
TL;DR: The performance of current diagnostic assays for bladder cancer is assessed and some of the emerging biomarkers that could be developed to augment current bladder cancer detection strategies are discussed.
Journal ArticleDOI
LncRNA-SARCC suppresses renal cell carcinoma (RCC) progression via altering the androgen receptor(AR)/miRNA-143-3p signals.
Wei Zhai,Wei Zhai,Wei Zhai,Yin Sun,Changcheng Guo,Changcheng Guo,Guanghui Hu,Mingchao Wang,Mingchao Wang,Jiayi Zheng,WanYing Lin,Qingbo Huang,Gonghui Li,Junhua Zheng,Chawnshang Chang,Chawnshang Chang +15 more
TL;DR: This study discovered the novel LncRNA-SARCC, which was suppressed and associated with better prognosis in RCC, and presented a road map for targeting this newly identified LncRNAs and its pathway, which expands potential therapeutic strategies for RCC treatment.
Journal ArticleDOI
Extracellular microRNAs in urologic malignancies: chances and challenges.
TL;DR: This review of recent publications involving extracellular miRNA profiling studies in three representative urologic cancers, including: prostate cancer, bladder cancer, and renal cell carcinoma, focuses on the diagnostic, prognostic, and therapeutic potential of these miRNAs in biological fluids, such as serum, plasma, and urine.
References
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Journal ArticleDOI
MicroRNAs: Target Recognition and Regulatory Functions
TL;DR: The current understanding of miRNA target recognition in animals is outlined and the widespread impact of miRNAs on both the expression and evolution of protein-coding genes is discussed.
Journal ArticleDOI
Circulating microRNAs as stable blood-based markers for cancer detection
Patrick S. Mitchell,Rachael K. Parkin,Evan M. Kroh,Brian R. Fritz,Brian R. Fritz,Stacia K. Wyman,Era L. Pogosova-Agadjanyan,Amelia Peterson,Jennifer Noteboom,Kathy O'Briant,April Allen,Daniel W. Lin,Daniel W. Lin,Daniel W. Lin,Nicole Urban,Charles W. Drescher,Beatrice S. Knudsen,Derek L. Stirewalt,Robert Gentleman,Robert L. Vessella,Robert L. Vessella,Peter S. Nelson,Daniel Martin,Daniel Martin,Muneesh Tewari +24 more
TL;DR: It is shown here that miRNAs are present in human plasma in a remarkably stable form that is protected from endogenous RNase activity and established the measurement of tumor-derived mi RNAs in serum or plasma as an important approach for the blood-based detection of human cancer.
Journal ArticleDOI
A microRNA polycistron as a potential human oncogene
Lin He,J. Michael Thomson,Michael T. Hemann,Eva Hernando-Monge,David Mu,Summer G. Goodson,Scott Powers,Carlos Cordon-Cardo,Scott W. Lowe,Gregory J. Hannon,Scott M. Hammond +10 more
TL;DR: It is found that the levels of the primary or mature microRNAs derived from the mir-17–92 locus are often substantially increased in human B-cell lymphomas, and the cluster is implicate as a potential human oncogene.
Mammalian microRNAs predominantly act to decrease target mRNA levels
Huili Guo,Nicholas T. Ingolia,Nicholas T. Ingolia,Jonathan S. Weissman,Jonathan S. Weissman,David P. Bartel +5 more
TL;DR: Results show that changes in mRNA levels closely reflect the impact of miRNAs on gene expression and indicate that destabilization of target mRNAs is the predominant reason for reduced protein output.
Journal ArticleDOI
Mammalian microRNAs predominantly act to decrease target mRNA levels
Huili Guo,Nicholas T. Ingolia,Nicholas T. Ingolia,Jonathan S. Weissman,Jonathan S. Weissman,David P. Bartel +5 more
TL;DR: In this paper, the authors used ribosome profiling to measure the overall effects on protein production and compare these to simultaneously measured effects on mRNA levels, showing that changes in mRNA levels closely reflect the impact of miRNAs on gene expression and indicate that destabilization of target mRNAs is the predominant reason for reduced protein output.
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Circulating microRNAs as stable blood-based markers for cancer detection
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