Journal ArticleDOI
MicroRNA in prostate, bladder, and kidney cancer: a systematic review.
James W.F. Catto,Antonio Alcaraz,Anders Bjartell,Ralph W deVere White,Christopher P. Evans,Susanne Füssel,Freddie C. Hamdy,Olli Kallioniemi,Lourdes Mengual,Thorsten Schlomm,Tapio Visakorpi +10 more
TLDR
MiRNAs appear to be important modulators of urologic cancer, and many are functionally implicated in their pathogenesis.About:
This article is published in European Urology.The article was published on 2011-05-01. It has received 448 citations till now. The article focuses on the topics: Cancer & Gene silencing.read more
Citations
More filters
Journal ArticleDOI
Tunneling Nanotubes Mediated microRNA-155 Intercellular Transportation Promotes Bladder Cancer Cells' Invasive and Proliferative Capacity.
TL;DR: Investigation of differential microRNAs' expression in heterogeneous bladder cancer cells foundMiR-155 was confirmed to be a crucial factor sustaining T24 bladder cancer cell proliferation, migration and cell cycle progression by CCK8, Matrigel test andcell cycle analysis, respectively.
Journal ArticleDOI
Fibroblast growth factor receptors: multifactorial-contributors to tumor initiation and progression.
TL;DR: This review focuses on recent advances in the relationship between FGFR disorders and tumorigenesis, and examines the role of methylation, histone remodeling, microRNA regulation, single nucleotide polymorphisms, amplification, and fusion of FGFRs with other genes.
Journal ArticleDOI
Tumor miR-125b predicts recurrence and survival of patients with clear-cell renal cell carcinoma after surgical resection
TL;DR: The results showed that tumor miR‐125b is a potential independent adverse prognostic biomarker for recurrence and survival of patients with ccRCC after nephrectomy.
Journal ArticleDOI
Effects of miR-1236-3p and miR-370-5p on activation of p21 in various tumors and its inhibition on the growth of lung cancer cells.
Chuanchang Li,Qiangqiang Ge,Qiangqiang Ge,Jiaxuan Liu,Qingsong Zhang,Chenghe Wang,Chenghe Wang,Kai Cui,Zhong Chen +8 more
TL;DR: MiR-1236 and miR-370 can inhibit non-small-cell lung carcinoma cell growth by upregulating p21 expression in vitro, and microRNA-mediated RNAa depends on the cell context.
Journal ArticleDOI
Urinary microRNAs as potential biomarkers of pesticide exposure.
Brittany A. Weldon,Sara Pacheco Shubin,Marissa N. Smith,Tomomi Workman,Alexander Artemenko,William C. Griffith,Beti Thompson,Elaine M. Faustman +7 more
TL;DR: Six miRNAs were observed to be positively associated with farmworkers status during the post-harvest season and Expression of five of these miRNA trended towards a positive dose response relationship with organophosphate pesticide metabolites in farmworkers.
References
More filters
Journal ArticleDOI
MicroRNAs: Target Recognition and Regulatory Functions
TL;DR: The current understanding of miRNA target recognition in animals is outlined and the widespread impact of miRNAs on both the expression and evolution of protein-coding genes is discussed.
Journal ArticleDOI
Circulating microRNAs as stable blood-based markers for cancer detection
Patrick S. Mitchell,Rachael K. Parkin,Evan M. Kroh,Brian R. Fritz,Brian R. Fritz,Stacia K. Wyman,Era L. Pogosova-Agadjanyan,Amelia Peterson,Jennifer Noteboom,Kathy O'Briant,April Allen,Daniel W. Lin,Daniel W. Lin,Daniel W. Lin,Nicole Urban,Charles W. Drescher,Beatrice S. Knudsen,Derek L. Stirewalt,Robert Gentleman,Robert L. Vessella,Robert L. Vessella,Peter S. Nelson,Daniel Martin,Daniel Martin,Muneesh Tewari +24 more
TL;DR: It is shown here that miRNAs are present in human plasma in a remarkably stable form that is protected from endogenous RNase activity and established the measurement of tumor-derived mi RNAs in serum or plasma as an important approach for the blood-based detection of human cancer.
Journal ArticleDOI
A microRNA polycistron as a potential human oncogene
Lin He,J. Michael Thomson,Michael T. Hemann,Eva Hernando-Monge,David Mu,Summer G. Goodson,Scott Powers,Carlos Cordon-Cardo,Scott W. Lowe,Gregory J. Hannon,Scott M. Hammond +10 more
TL;DR: It is found that the levels of the primary or mature microRNAs derived from the mir-17–92 locus are often substantially increased in human B-cell lymphomas, and the cluster is implicate as a potential human oncogene.
Mammalian microRNAs predominantly act to decrease target mRNA levels
Huili Guo,Nicholas T. Ingolia,Nicholas T. Ingolia,Jonathan S. Weissman,Jonathan S. Weissman,David P. Bartel +5 more
TL;DR: Results show that changes in mRNA levels closely reflect the impact of miRNAs on gene expression and indicate that destabilization of target mRNAs is the predominant reason for reduced protein output.
Journal ArticleDOI
Mammalian microRNAs predominantly act to decrease target mRNA levels
Huili Guo,Nicholas T. Ingolia,Nicholas T. Ingolia,Jonathan S. Weissman,Jonathan S. Weissman,David P. Bartel +5 more
TL;DR: In this paper, the authors used ribosome profiling to measure the overall effects on protein production and compare these to simultaneously measured effects on mRNA levels, showing that changes in mRNA levels closely reflect the impact of miRNAs on gene expression and indicate that destabilization of target mRNAs is the predominant reason for reduced protein output.
Related Papers (5)
MicroRNA expression profiles classify human cancers
Jun Lu,Gad Getz,Eric A. Miska,Eric A. Miska,Ezequiel Alvarez-Saavedra,Justin Lamb,David Peck,Alejandro Sweet-Cordero,Alejandro Sweet-Cordero,Benjamin L. Ebert,Benjamin L. Ebert,Raymond H. Mak,Raymond H. Mak,Adolfo A. Ferrando,James R. Downing,Tyler Jacks,H. Robert Horvitz,H. Robert Horvitz,Todd R. Golub,Todd R. Golub,Todd R. Golub +20 more
Circulating microRNAs as stable blood-based markers for cancer detection
Patrick S. Mitchell,Rachael K. Parkin,Evan M. Kroh,Brian R. Fritz,Brian R. Fritz,Stacia K. Wyman,Era L. Pogosova-Agadjanyan,Amelia Peterson,Jennifer Noteboom,Kathy O'Briant,April Allen,Daniel W. Lin,Daniel W. Lin,Daniel W. Lin,Nicole Urban,Charles W. Drescher,Beatrice S. Knudsen,Derek L. Stirewalt,Robert Gentleman,Robert L. Vessella,Robert L. Vessella,Peter S. Nelson,Daniel Martin,Daniel Martin,Muneesh Tewari +24 more