Journal ArticleDOI
MicroRNA in prostate, bladder, and kidney cancer: a systematic review.
James W.F. Catto,Antonio Alcaraz,Anders Bjartell,Ralph W deVere White,Christopher P. Evans,Susanne Füssel,Freddie C. Hamdy,Olli Kallioniemi,Lourdes Mengual,Thorsten Schlomm,Tapio Visakorpi +10 more
TLDR
MiRNAs appear to be important modulators of urologic cancer, and many are functionally implicated in their pathogenesis.About:
This article is published in European Urology.The article was published on 2011-05-01. It has received 448 citations till now. The article focuses on the topics: Cancer & Gene silencing.read more
Citations
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Journal ArticleDOI
Personalized management in low-risk prostate cancer: the role of biomarkers.
Siebren Dijkstra,Agus Rizal Ardy Hariandy Hamid,Agus Rizal Ardy Hariandy Hamid,Gisele H. J. M. Leyten,Jack A. Schalken +4 more
TL;DR: An overview of the current available serum-, urine-, and tissue-based biomarkers in PCa is provided and the clinical usefulness of these biomarkers is evaluated in the detection and management of low-risk PCa.
C URRENT OPINION Noncoding RNA in bladder cancer: a specific focus upon high-risk nonmuscle invasive disease
Aidan P. Noon,James W.F. Catto +1 more
TL;DR: In this paper, the authors reviewed knowledge of ncRNA in bladder cancer, with a focus upon their role in high-risk non-muscle invasive tumors, and reported the ability of microRNAs to help evaluate patients with non-mule invasive bladder cancer.
Journal ArticleDOI
Epigenetic Control of Gene Expression in the Normal and Malignant Human Prostate: A Rapid Response Which Promotes Therapeutic Resistance.
TL;DR: In a multicellular model of human prostate cancer, flexible responses are primarily governed not only by de novo mutations but appear to be dominated by a combination of epigenetic controls, whose application results in treatment resistance and tumor relapse.
Journal ArticleDOI
Urinary microRNA can be concentrated, dried on membranes and stored at room temperature in vacuum bags
TL;DR: It is demonstrated that urinary micro RNA can be concentrated, dried on membranes and stored in vacuum bags at room temperature for several months, making the large-scale storage of clinical samples of urinary microRNA or other nucleic acids possible.
Journal ArticleDOI
In-Silico Integration Approach to Identify a Key miRNA Regulating a Gene Network in Aggressive Prostate Cancer.
Claudia Cava,Gloria Bertoli,Antonio Colaprico,Gianluca Bontempi,Giancarlo Mauri,Isabella Castiglioni +5 more
TL;DR: The results identify a four-gene signature with diagnostic and prognostic value in PC and suggest an interesting gene network that could play a key regulatory role in PC development and progression and hsa-miR-153, controlling this network, could be a potential biomarker for theranostics in high Gleason-scored PC.
References
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Journal ArticleDOI
MicroRNAs: Target Recognition and Regulatory Functions
TL;DR: The current understanding of miRNA target recognition in animals is outlined and the widespread impact of miRNAs on both the expression and evolution of protein-coding genes is discussed.
Journal ArticleDOI
Circulating microRNAs as stable blood-based markers for cancer detection
Patrick S. Mitchell,Rachael K. Parkin,Evan M. Kroh,Brian R. Fritz,Brian R. Fritz,Stacia K. Wyman,Era L. Pogosova-Agadjanyan,Amelia Peterson,Jennifer Noteboom,Kathy O'Briant,April Allen,Daniel W. Lin,Daniel W. Lin,Daniel W. Lin,Nicole Urban,Charles W. Drescher,Beatrice S. Knudsen,Derek L. Stirewalt,Robert Gentleman,Robert L. Vessella,Robert L. Vessella,Peter S. Nelson,Daniel Martin,Daniel Martin,Muneesh Tewari +24 more
TL;DR: It is shown here that miRNAs are present in human plasma in a remarkably stable form that is protected from endogenous RNase activity and established the measurement of tumor-derived mi RNAs in serum or plasma as an important approach for the blood-based detection of human cancer.
Journal ArticleDOI
A microRNA polycistron as a potential human oncogene
Lin He,J. Michael Thomson,Michael T. Hemann,Eva Hernando-Monge,David Mu,Summer G. Goodson,Scott Powers,Carlos Cordon-Cardo,Scott W. Lowe,Gregory J. Hannon,Scott M. Hammond +10 more
TL;DR: It is found that the levels of the primary or mature microRNAs derived from the mir-17–92 locus are often substantially increased in human B-cell lymphomas, and the cluster is implicate as a potential human oncogene.
Mammalian microRNAs predominantly act to decrease target mRNA levels
Huili Guo,Nicholas T. Ingolia,Nicholas T. Ingolia,Jonathan S. Weissman,Jonathan S. Weissman,David P. Bartel +5 more
TL;DR: Results show that changes in mRNA levels closely reflect the impact of miRNAs on gene expression and indicate that destabilization of target mRNAs is the predominant reason for reduced protein output.
Journal ArticleDOI
Mammalian microRNAs predominantly act to decrease target mRNA levels
Huili Guo,Nicholas T. Ingolia,Nicholas T. Ingolia,Jonathan S. Weissman,Jonathan S. Weissman,David P. Bartel +5 more
TL;DR: In this paper, the authors used ribosome profiling to measure the overall effects on protein production and compare these to simultaneously measured effects on mRNA levels, showing that changes in mRNA levels closely reflect the impact of miRNAs on gene expression and indicate that destabilization of target mRNAs is the predominant reason for reduced protein output.
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