Journal ArticleDOI
Molecular networks that regulate cancer metastasis.
TLDR
This work addresses several genetic events and critical factors that define the metastatic phenotype acquired during tumorigenesis that provide the basis for the development of new aspects in the treatment of metastatic cancers, which involves inhibition of these proteins and their molecular networks.About:
This article is published in Seminars in Cancer Biology.The article was published on 2012-06-01. It has received 314 citations till now. The article focuses on the topics: Intravasation & Metastasis.read more
Citations
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Cancer metastases: challenges and opportunities.
TL;DR: The biochemical events and parameters involved in the metastatic process and tumor microenvironment have been targeted or can be potential targets for metastasis prevention and inhibition and this review provides an overview of them.
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Immunity, inflammation and cancer: a leading role for adenosine
TL;DR: The role of adenosine and its receptors in regulating the complex interplay among immune, inflammatory, endothelial and cancer cells during the course of neoplastic disease is critically discussed.
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Rho GTPase signalling in cell migration.
TL;DR: Recent advances in understanding of how Rho GTPases contribute to different types of migration are reviewed, comparing lamellipodium-driven versus bleb-driven migration modes and how cells migrate across the endothelium is described.
Journal ArticleDOI
Breast cancer as a systemic disease: a view of metastasis
TL;DR: Results from studies in animal models suggest that specific subtypes of breast cancer may direct metastasis through recruitment and activation of haematopoietic cells, and data implicating breast cancer as a systemic disease is focused on.
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Exosomes from metastatic cancer cells transfer amoeboid phenotype to non-metastatic cells and increase endothelial permeability: their emerging role in tumor heterogeneity
Odessa Schillaci,Simona Fontana,Francesca Monteleone,Simona Taverna,Maria Antonietta Di Bella,Dolores Di Vizio,Riccardo Alessandro,Riccardo Alessandro +7 more
TL;DR: The results demonstrate that in a heterogeneous context exosomes released by aggressive sub-clones can contribute to accelerate tumor progression by spreading malignant properties that affect both the tumor cell plasticity and the endothelial cell behavior.
References
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Epithelial-Mesenchymal Transitions in Development and Disease
Jean Paul Thiery,Jean Paul Thiery,Hervé Acloque,Ruby Yun-Ju Huang,Ruby Yun-Ju Huang,M. Angela Nieto +5 more
TL;DR: The mesenchymal state is associated with the capacity of cells to migrate to distant organs and maintain stemness, allowing their subsequent differentiation into multiple cell types during development and the initiation of metastasis.
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The basics of epithelial-mesenchymal transition
Raghu Kalluri,Robert A. Weinberg +1 more
TL;DR: Processes similar to the EMTs associated with embryo implantation, embryogenesis, and organ development are appropriated and subverted by chronically inflamed tissues and neoplasias and the identification of the signaling pathways that lead to activation of EMT programs during these disease processes is providing new insights into the plasticity of cellular phenotypes.
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Involvement of chemokine receptors in breast cancer metastasis.
Anja Müller,Bernhard Homey,Hortensia Soto,Nianfeng Ge,Daniel Catron,Matthew E. Buchanan,Terri McClanahan,Erin Murphy,Wei Yuan,Stephan N. Wagner,Jose Luis Barrera,Alejandro Mohar,Emma Verastegui,Albert Zlotnik +13 more
TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
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Fibroblasts in cancer
TL;DR: Fibroblasts are a key determinant in the malignant progression of cancer and represent an important target for cancer therapies.