Journal ArticleDOI
Molecular virology of the hepatitis C virus
TLDR
The NS5B protein has been shown to be the viral RNA-dependent RNA polymerase, which has been suggested that NS5A is involved in mediating the resistance of the hepatitis C virus to the action of interferon.About:
This article is published in Journal of Hepatology.The article was published on 1999-01-01. It has received 70 citations till now. The article focuses on the topics: NS3 & NS5B.read more
Citations
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Journal ArticleDOI
A Natural Intergenotypic Recombinant of Hepatitis C Virus Identified in St. Petersburg
TL;DR: It is shown that recombination may play a role in the evolution of Hepatitis C virus (HCV), and Recombination between HCV genotypes must now be considered in the classification, laboratory diagnosis, and treatment of HCV infection.
Journal ArticleDOI
Curcumin and Liver Disease: from Chemistry to Medicine
Seyed Fazel Nabavi,Maria Daglia,Akbar Hajizadeh Moghaddam,Solomon Habtemariam,Seyed Mohammad Nabavi +4 more
TL;DR: Overall, scientific reports demonstrate that curcumin has high therapeutic ability for treating hepatic disorders and its possible mechanisms of actions are discussed.
Journal ArticleDOI
Apoptosis in hepatitis C virus infection.
TL;DR: Data about the role of single HCV proteins, either in cultured cells or transgenic animals models, however, are contradictory, as both pro- and anti-apoptotic effects have been observed.
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Molecular Mechanisms Underlying Occult Hepatitis B Virus Infection
TL;DR: The molecular mechanisms underlying occult HBV infections, including recently identified mechanisms associated with the suppression ofHBV replication and inhibition of HBV proteins, are reviewed in detail.
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Sustained activation of the Raf/MEK/Erk pathway in response to EGF in stable cell lines expressing the Hepatitis C Virus (HCV) core protein
TL;DR: The ability ofHCV core proteins to directly activate the MAP kinase cascade and to prolong its activity in response to mitogenic stimuli may contribute to the neoplastic transformation of HCV infected liver cells.
References
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Journal ArticleDOI
Binding of Hepatitis C Virus to CD81
Piero Pileri,Yasushi Uematsu,Susanna Campagnoli,Giuliano Galli,Fabiana Falugi,Roberto Petracca,Amy J. Weiner,Michael Houghton,Domenico Rosa,Guido Grandi,Sergio Abrignani +10 more
TL;DR: Recombinant molecules containing this loop bound HCV and antibodies that neutralize HCV infection in vivo inhibited virus binding to CD81 in vitro.
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The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice.
Kyoji Moriya,Hajime Fujie,Yoshizumi Shintani,Hiroshi Yotsuyanagi,Takeya Tsutsumi,Kotaro Ishibashi,Yoshiharu Matsuura,Satoshi Kimura,Tatsuo Miyamura,Kazuhiko Koike +9 more
TL;DR: It is indicated that the HCV core protein has a chief role in the development of HCC, and that these transgenic mice provide good animal models for determining the molecular events in hepatocarcinogenesis with HCV infection.
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Helicases: amino acid sequence comparisons and structure-function relationships
TL;DR: Three large superfamilies and two smaller families of helicases are described and experimental results support the value of the conserved motifs for prediction of structure and function of the helicases.
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Mutations in the Nonstructural Protein 5a Gene and Response to Interferon in Patients with Chronic Hepatitis C Virus 1b Infection
Nobuyuki Enomoto,Ikuo Sakuma,Yasuhiro Asahina,Masayuki Kurosaki,Takeshi Murakami,Chikara Yamamoto,Yuki Ogura,Namiki Izumi,Fumiaki Marumo,Chifumi Sato +9 more
TL;DR: In patients with chronic HCV-1b infection, there is a substantial correlation between responses to interferon and mutations in the NS5A gene.
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Expression and identification of hepatitis C virus polyprotein cleavage products.
TL;DR: The data indicate that at least nine polypeptides are produced by cleavage of the HCV H strain polyprotein, and preliminary results suggest that a fraction of E1 is associated with E2 and E2-NS2 via disulfide linkages.