Multi-functional bismuth-doped bioglasses: combining bioactivity and photothermal response for bone tumor treatment and tissue repair.
Liping Wang,Nicholas J. Long,Lihua Li,Yao Lu,Mei Li,Jiangkun Cao,Yu Zhang,Qinyuan Zhang,Shanhui Xu,Zhongmin Yang,Chuanbin Mao,Mingying Peng +11 more
TLDR
By illuminating bismuth-doped bioglass with near-infrared light, the researchers have developed a new technique that can kill bone tumor cells and enable photoinduced hyperthermia and bioactivity, reducing the number of treatments required to repair bone tissue.Abstract:
Treatment of large bone defects derived from bone tumor surgery is typically performed in multiple separate operations, such as hyperthermia to extinguish residual malignant cells or implanting bioactive materials to initiate apatite remineralization for tissue repair; it is very challenging to combine these functions into a material. Herein, we report the first photothermal (PT) effect in bismuth (Bi)-doped glasses. On the basis of this discovery, we have developed a new type of Bi-doped bioactive glass that integrates both functions, thus reducing the number of treatment cycles. We demonstrate that Bi-doped bioglasses (BGs) provide high PT efficiency, potentially facilitating photoinduced hyperthermia and bioactivity to allow bone tissue remineralization. The PT effect of Bi-doped BGs can be effectively controlled by managing radiative and non-radiative processes of the active Bi species by quenching photoluminescence (PL) or depolymerizing glass networks. In vitro studies demonstrate that such glasses are biocompatible to tumor and normal cells and that they can promote osteogenic cell proliferation, differentiation, and mineralization. Upon illumination with near-infrared (NIR) light, the bioglass (BG) can efficiently kill bone tumor cells, as demonstrated via in vitro and in vivo experiments. This indicates excellent potential for the integration of multiple functions within the new materials, which will aid in the development and application of novel biomaterials.read more
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Tunable nanophotonics enabled by chalcogenide phase-change materials
Sajjad Abdollahramezani,Omid Hemmatyar,Hossein Taghinejad,Alex Krasnok,Yashar Kiarashinejad,Mohammadreza Zandehshahvar,Andrea Alù,Ali Adibi +7 more
TL;DR: The unique material properties, structural transformation, and thermo-optic effects of well-established classes of chalcogenide PCMs are outlined and the emerging deep learning-based approaches for the optimization of reconfigurable MSs and the analysis of light-matter interactions are discussed.
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The versatile biomedical applications of bismuth-based nanoparticles and composites: therapeutic, diagnostic, biosensing, and regenerative properties
Mohammad-Ali Shahbazi,Mohammad-Ali Shahbazi,Leila Faghfouri,Mónica P. A. Ferreira,Patrícia Figueiredo,Hajar Maleki,Farshid Sefat,Jouni Hirvonen,Hélder A. Santos +8 more
TL;DR: This review emphasizes the synthesis and state-of-the-art progress related to the biomedical applications of BiNPs with different structures, sizes, and compositions.
Journal ArticleDOI
Optical Anapoles: Concepts and Applications
Kseniia V. Baryshnikova,Daria A. Smirnova,Daria A. Smirnova,Boris Luk'yanchuk,Boris Luk'yanchuk,Yuri S. Kivshar,Yuri S. Kivshar +6 more
TL;DR: The work was supported by the Government of the======Russian Federation (Grant 08-08), the Ministry of Science and Higher Education of the Russian Federation (project No. 16.12780.2018/12.W03.0008), the Russian Foundation for Basic Research (Grant 18-02-00381), the======Australian Research Council, and the Strategic Fund of the Australian National University.
Journal ArticleDOI
2D MXene-Integrated 3D-Printing Scaffolds for Augmented Osteosarcoma Phototherapy and Accelerated Tissue Reconstruction.
Shanshan Pan,Shanshan Pan,Junhui Yin,Luodan Yu,Changqing Zhang,Yufang Zhu,Yufang Zhu,You-Shui Gao,Yu Chen +8 more
TL;DR: The rational integration of 2D Ti3C2 MXene is demonstrated to efficiently accelerate the in vivo growth of newborn bone tissue of the composite BG scaffolds for achieving concurrent bone‐tumor killing by photonic hyperthermia and bone-tissue regeneration by bioactive scaffolds.
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