Journal ArticleDOI
Neferine augments therapeutic efficacy of cisplatin through ROS- mediated non-canonical autophagy in human lung adenocarcinoma (A549 cells).
Sivalingam Kalai Selvi,Amirthalingam Vinoth,Thiyagarajan Varadharajan,Ching-Feng Weng,V. Vijaya Padma,V. Vijaya Padma,V. Vijaya Padma +6 more
TLDR
It is suggested that neferine enhances cisplatin -induced autophagic cancer cell death through downregulation of PI3K/Akt/mTOR signaling pro-survival pathway and ROS- mediated Beclin-1 andPI3K CIII independent autophagy in human lung adenocarcinoma (A549 cells).About:
This article is published in Food and Chemical Toxicology.The article was published on 2017-05-01. It has received 51 citations till now. The article focuses on the topics: PI3K/AKT/mTOR pathway & Autophagy.read more
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Targeting PI3K/AKT/mTOR-mediated autophagy for tumor therapy
TL;DR: The roles of PI3K/AKT/mTOR-mediated autophagy in tumorigenesis, progression, and drug resistance of tumors are summarized and may be utilized to design preferably therapeutic strategies for various tumors.
Journal ArticleDOI
Gold-Based Medicine: A Paradigm Shift in Anti-Cancer Therapy?
TL;DR: An account of the latest research conducted during the last decade or so on the development of gold compounds and their potential activities against several cancers as well as a summary of possible mechanisms of action/biological targets are provided.
Journal ArticleDOI
Escin induces caspase-dependent apoptosis and autophagy through the ROS/p38 MAPK signalling pathway in human osteosarcoma cells in vitro and in vivo
Jian Zhu,Wei Yu,Bing Liu,Yitian Wang,Jianlin shao,Junjie Wang,Kaishun Xia,Chengzhen Liang,Weijing Fang,Chenhe Zhou,Huimin Tao +10 more
TL;DR: Overall, escin counteracted osteosarcoma by inducing autophagy and apoptosis via the activation of the ROS/p38 MAPK signalling pathway; these findings provide evidence for escin as a novel and potent therapeutic for the treatment of osteosARcoma.
Journal ArticleDOI
Melatonin and Autophagy in Aging-Related Neurodegenerative Diseases
Fang Luo,Aaron F. Sandhu,Wiramon Rungratanawanich,George E. Williams,Mohammed Akbar,Shuanhu Zhou,Byoung Joon Song,Xin Wang +7 more
TL;DR: The neuroprotective role of melatonin against various N DDs via regulating autophagy is discussed, which could be a new field for future translational research and clinical studies to discover preventive or therapeutic agents for many NDDs.
Journal ArticleDOI
Pharmacological benefits of neferine - A comprehensive review
Shibu Marthandam Asokan,Ravichandran Mariappan,Shanmugavadivu Muthusamy,Bharath Kumar Velmurugan +3 more
TL;DR: This article recapitulates the existing in vitro and in vivo studies focusing on the effects of neferine‐an alkaloid derivative of lotus plant, in various disease models and its effects on key signaling molecules and compiles a large number of research studies that demonstrate methods for isolation and extraction, biosynthetic pathway, pharmacological activity and mode of action of nferine and their underlying mechanisms at cellular level.
References
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Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method
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Classification of cell death: recommendations of the Nomenclature Committee on Cell Death
Guido Kroemer,Guido Kroemer,Guido Kroemer,Lorenzo Galluzzi,Lorenzo Galluzzi,Lorenzo Galluzzi,Peter Vandenabeele,John M. Abrams,Emad S. Alnemri,Eric H. Baehrecke,Mikhail V. Blagosklonny,Wafik S. El-Deiry,Pierre Golstein,Pierre Golstein,Douglas R. Green,Michael O. Hengartner,Richard A. Knight,Sharad Kumar,Stuart A. Lipton,Stuart A. Lipton,Stuart A. Lipton,Walter Malorni,Gabriel Núñez,Marcus E. Peter,Juerg Tschopp,Junying Yuan,Mauro Piacentini,Boris Zhivotovsky,Gerry Melino,Gerry Melino +29 more
TL;DR: This study details the 2009 recommendations of the NCCD on the use of cell death-related terminology including ‘entosis’, ‘mitotic catastrophe”,’ ‘necrosis‚ ‘necroptosis‚’ and ‘pyroptotic’.