Neuroimaging of Inflammation in Memory and Related Other Disorders (NIMROD) study protocol: a deep phenotyping cohort study of the role of brain inflammation in dementia, depression and other neurological illnesses
W Richard Bevan-Jones,Ajenthan Surendranathan,Luca Passamonti,Patricia Vázquez Rodríguez,Robert Arnold,Elijah Mak,Li Su,Jonathan P. Coles,Tim D. Fryer,Young T. Hong,Guy B. Williams,Franklin I. Aigbirhio,James B. Rowe,John T. O'Brien +13 more
TLDR
This study will explore pathophysiological mechanisms using positron emission tomography (PET) which allows in vivo imaging of inflammation, amyloid and τ deposition, together with neuropsychological profiling, MRI and peripheral biomarker analysis, and determine the correlation between central inflammation and peripheral inflammation.Citations
More filters
Journal ArticleDOI
NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease
Clifford R. Jack,David A. Bennett,Kaj Blennow,Maria C. Carrillo,Billy Dunn,Samantha Budd Haeberlein,David M. Holtzman,William J. Jagust,Frank Jessen,Jason Karlawish,Enchi Liu,José Luis Molinuevo,Thomas J. Montine,Creighton H. Phelps,Katherine P. Rankin,Christopher C. Rowe,Philip Scheltens,Eric Siemers,Heather M. Snyder,Reisa A. Sperling,Cerise L Elliott,Eliezer Masliah,Laurie M. Ryan,Nina Silverberg +23 more
TL;DR: This research framework seeks to create a common language with which investigators can generate and test hypotheses about the interactions among different pathologic processes (denoted by biomarkers) and cognitive symptoms and envision that defining AD as a biological construct will enable a more accurate characterization and understanding of the sequence of events that lead to cognitive impairment that is associated with AD.
Journal ArticleDOI
18F-AV-1451 positron emission tomography in Alzheimer's disease and progressive supranuclear palsy.
Luca Passamonti,Patricia Vázquez Rodríguez,Young T. Hong,Kieren Allinson,David Williamson,Robin J Borchert,Saber Sami,Thomas E. Cope,W Richard Bevan-Jones,P. Simon Jones,Robert Arnold,Ajenthan Surendranathan,Elijah Mak,Li Su,Tim D. Fryer,Franklin I. Aigbirhio,John T. O'Brien,James B. Rowe +17 more
TL;DR: By comparing patients with Alzheimer’s disease and progressive supranuclear palsy, Passamonti et al. show that [18F]AV-1451 displays greater specificity for Alzheimer-related tau pathology than PSP-related pathology.
Journal ArticleDOI
Tau burden and the functional connectome in Alzheimer’s disease and progressive supranuclear palsy
Thomas E. Cope,Timothy Rittman,Robin J Borchert,P. Simon Jones,Deniz Vatansever,Kieren Allinson,Luca Passamonti,Patricia Vázquez Rodríguez,W Richard Bevan-Jones,John T. O'Brien,James B. Rowe,James B. Rowe +11 more
TL;DR: By evaluating tau burden and functional connectivity in living patients, Cope et al. demonstrate relationships consistent with this in Alzheimer's disease but not progressive supranuclear palsy.
Journal ArticleDOI
Myocardial Inflammation Predicts Remodeling and Neuroinflammation After Myocardial Infarction.
James T. Thackeray,Henri C. Hupe,Yong Wang,Jens P. Bankstahl,Georg Berding,Tobias L. Ross,Johann Bauersachs,Kai C. Wollert,Frank M. Bengel +8 more
TL;DR: The brain is susceptible to acute MI and chronic heart failure, and immune activation may interconnect heart and brain dysfunction, a finding that provides a foundation for strategies to improve heart andbrain outcomes.
Journal ArticleDOI
Neuroinflammation and Functional Connectivity in Alzheimer's Disease: Interactive Influences on Cognitive Performance
Luca Passamonti,Kamen A. Tsvetanov,P.S. Jones,William Richard Bevan-Jones,Robert Arnold,Robin J Borchert,Elijah Mak,Li Su,John T. O'Brien,James B. Rowe +9 more
TL;DR: It is provided clear evidence that in vivo neuroinflammation in AD impairs large-scale network connectivity; and that the link between neuro inflammation and functional network connectivity is relevant to cognitive impairment.
References
More filters
Journal ArticleDOI
The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease
Guy M. McKhann,Guy M. McKhann,David S. Knopman,Howard Chertkow,Bradley T. Hyman,Clifford R. Jack,Claudia H. Kawas,William E. Klunk,Walter J. Koroshetz,Jennifer J. Manly,Richard Mayeux,Richard C. Mohs,John C. Morris,Martin N. Rossor,Philip Scheltens,Maria C. Carrillo,Bill Thies,Sandra Weintraub,Creighton H. Phelps +18 more
TL;DR: The workgroup sought to ensure that the revised criteria would be flexible enough to be used by both general healthcare providers without access to neuropsychological testing, advanced imaging, and cerebrospinal fluid measures, and specialized investigators involved in research or in clinical trial studies who would have these tools available.
Journal ArticleDOI
Neuropathological stageing of Alzheimer-related changes.
Heiko Braak,Eva Braak +1 more
TL;DR: The investigation showed that recognition of the six stages required qualitative evaluation of only a few key preparations, permitting the differentiation of six stages.
Journal ArticleDOI
A new depression scale designed to be sensitive to change.
Stuart Montgomery,Marie Åsberg +1 more
TL;DR: The construction of a depression rating scale designed to be particularly sensitive to treatment effects is described, and its capacity to differentiate between responders and non-responders to antidepressant treatment was better than the HRS, indicating greater sensitivity to change.
Journal ArticleDOI
Alpha-synuclein in Lewy bodies.
Maria Grazia Spillantini,Marie L. Schmidt,Virginia M.-Y. Lee,John Q. Trojanowski,Ross Jakes,Michel Goedert +5 more
TL;DR: Strong staining of Lewy bodies from idiopathic Parkinson's disease with antibodies for α-synuclein, a presynaptic protein of unknown function which is mutated in some familial cases of the disease, indicates that the LewY bodies from these two diseases may have identical compositions.
Journal ArticleDOI
The Neuropsychiatric Inventory: Comprehensive assessment of psychopathology in dementia
Jeffrey L. Cummings,Michael S. Mega,Kevin F. Gray,S. Rosenberg-Thompson,Daniela Carusi,Jeffrey Gornbein +5 more
TL;DR: The NPI has the advantages of evaluating a wider range of psychopathology than existing instruments, soliciting information that may distinguish among different etiologies of dementia, differentiating between severity and frequency of behavioral changes, and minimizing administration time.
Related Papers (5)
The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease
Guy M. McKhann,Guy M. McKhann,David S. Knopman,Howard Chertkow,Bradley T. Hyman,Clifford R. Jack,Claudia H. Kawas,William E. Klunk,Walter J. Koroshetz,Jennifer J. Manly,Richard Mayeux,Richard C. Mohs,John C. Morris,Martin N. Rossor,Philip Scheltens,Maria C. Carrillo,Bill Thies,Sandra Weintraub,Creighton H. Phelps +18 more
Validating novel tau positron emission tomography tracer [F‐18]‐AV‐1451 (T807) on postmortem brain tissue
Marta Marquié,Marta Marquié,Marc D. Normandin,Charles R. Vanderburg,Isabel Costantino,Elizabeth Bien,Lisa G. Rycyna,William E. Klunk,Chester A. Mathis,Milos D. Ikonomovic,Milos D. Ikonomovic,Manik L. Debnath,Neil Vasdev,Bradford C. Dickerson,Stephen N. Gomperts,John H. Growdon,Keith A. Johnson,Matthew P. Frosch,Bradley T. Hyman,Teresa Gomez-Isla +19 more