Thomas E. Cope

TL;DR: By comparing patients with Alzheimer’s disease and progressive supranuclear palsy, Passamonti et al. show that [18F]AV-1451 displays greater specificity for Alzheimer-related tau pathology than PSP-related pathology.

TL;DR: By evaluating tau burden and functional connectivity in living patients, Cope et al. demonstrate relationships consistent with this in Alzheimer's disease but not progressive supranuclear palsy.

TL;DR: An international study of age at symptom onset, age at death, and disease duration in individuals with mutations in GRN, MAPT, and C9orf72 to investigate the extent to which variability in age at onset and at death could be accounted for by family membership and the specific mutation carried.

TL;DR: In this article, the authors used functional and structural MRI coupled with physiological measurements to demonstrate that trigger sounds elicit greatly exaggerated bloodoxygen-level-dependent (BOLD) responses in the anterior insular cortex (AIC), a core hub of the salience network that is critical for perception of interoceptive signals and emotion processing.

TL;DR: It is shown that selective neurodegeneration of human frontal speech regions results in delayed reconciliation of predictions in temporal cortex and results in inflexible prior expectations, indicating that fronto-temporal interactions determine predictive processes in speech.