Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis
Jonathan Cools-Lartigue,Jonathan Spicer,Braedon McDonald,Stephen Gowing,Simon C. Chow,Betty Giannias,Paul Kubes,Lorenzo E. Ferri +7 more
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It is reported that circulating tumor cells become trapped within NETs in vitro under static and dynamic conditions and NETs are identified as potential therapeutic targets in the context of systemic infection.Abstract:
The majority of patients with cancer undergo at least one surgical procedure as part of their treatment. Severe postsurgical infection is associated with adverse oncologic outcomes; however, the mechanisms underlying this phenomenon are unclear. Emerging evidence suggests that neutrophils, which function as the first line of defense during infections, facilitate cancer progression. Neutrophil extracellular traps (NETs) are extracellular neutrophil-derived DNA webs released in response to inflammatory cues that trap and kill invading pathogens. The role of NETs in cancer progression is entirely unknown. We report that circulating tumor cells become trapped within NETs in vitro under static and dynamic conditions. In a murine model of infection using cecal ligation and puncture, we demonstrated microvascular NET deposition and consequent trapping of circulating lung carcinoma cells within DNA webs. NET trapping was associated with increased formation of hepatic micrometastases at 48 hours and gross metastatic disease burden at 2 weeks following tumor cell injection. These effects were abrogated by NET inhibition with DNAse or a neutrophil elastase inhibitor. These findings implicate NETs in the process of cancer metastasis in the context of systemic infection and identify NETs as potential therapeutic targets.read more
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Dissertation
Contribution of tumor-associated neutrophils in the course of cutaneous squamous cell carcinoma : neutrophils and cancer
TL;DR: The aim of this research was to further characterize the functions and the contribution of neutrophils to the development of cutaneous squamous cell carcinomas and suggest that it is relevant to assess immunotherapies that block PD-L1/PD1 interaction for the treatment for cSCC.
Journal ArticleDOI
The role of extracellular vesicles and interleukin-8 in regulating and mediating neutrophil-dependent cancer drug resistance
Mara Zippoli,Anna Ruocco,Rubina Novelli,Francesca Rocchio,Martina Sara Miscione,Marcello Allegretti,Maria Candida Cesta,Pier Giorgio Amendola +7 more
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The Role of Peptidyl Arginine Deiminase IV(PADI4) in Cancers.
TL;DR: PADI4 plays crucial roles in the occurrence, development and metastasis of tumors, and PADI 4 may be an effective biomarker for cancer prognosis and potential target for cancer treatment.
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Hepatocyte SGK1 activated by hepatic ischemia-reperfusion promotes the recurrence of liver metastasis via IL-6/STAT3
TL;DR: In this article , the changes of multiple signaling pathways during CRLM recurrence under liver ischemia-reperfusion (IR) background, including SGK1/IL-6/STAT3, neutrophil extracellular traps (NETs) formation, polymorphonuclear myeloid-derived suppressor cell (PMN-MDSC) infiltration, were evaluated.
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