Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis
Jonathan Cools-Lartigue,Jonathan Spicer,Braedon McDonald,Stephen Gowing,Simon C. Chow,Betty Giannias,Paul Kubes,Lorenzo E. Ferri +7 more
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TLDR
It is reported that circulating tumor cells become trapped within NETs in vitro under static and dynamic conditions and NETs are identified as potential therapeutic targets in the context of systemic infection.Abstract:
The majority of patients with cancer undergo at least one surgical procedure as part of their treatment. Severe postsurgical infection is associated with adverse oncologic outcomes; however, the mechanisms underlying this phenomenon are unclear. Emerging evidence suggests that neutrophils, which function as the first line of defense during infections, facilitate cancer progression. Neutrophil extracellular traps (NETs) are extracellular neutrophil-derived DNA webs released in response to inflammatory cues that trap and kill invading pathogens. The role of NETs in cancer progression is entirely unknown. We report that circulating tumor cells become trapped within NETs in vitro under static and dynamic conditions. In a murine model of infection using cecal ligation and puncture, we demonstrated microvascular NET deposition and consequent trapping of circulating lung carcinoma cells within DNA webs. NET trapping was associated with increased formation of hepatic micrometastases at 48 hours and gross metastatic disease burden at 2 weeks following tumor cell injection. These effects were abrogated by NET inhibition with DNAse or a neutrophil elastase inhibitor. These findings implicate NETs in the process of cancer metastasis in the context of systemic infection and identify NETs as potential therapeutic targets.read more
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Journal ArticleDOI
Prognostic value of circulating markers of neutrophil activation, neutrophil extracellular traps, coagulation and fibrinolysis in patients with terminal cancer
Axel Rosell,Katherina Aguilera,Yohei Hisada,Clare M. Schmedes,Nigel Mackman,Håkan Wallén,Staffan Lundström,Charlotte Thålin +7 more
TL;DR: In this paper, the authors performed a comprehensive investigation of circulating markers of neutrophil activation, extracellular traps (NETs), and formed, coagulation and fibrinolysis in 106 patients with terminal cancer.
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Pretreatment peripheral neutrophils, lymphocytes and monocytes predict long-term survival in hepatocellular carcinoma
TL;DR: Pretreatment peripheral neutrophils, lymphocytes, and monocytes are independently associated with outcomes of patients with HCC, and provides a noninvasive, low-cost, easy, and reproducible biomarker that can be used in routine clinical practice to predict the prognosis of patientswith HCC.
Book ChapterDOI
Immune Cell Metabolism in Tumor Microenvironment.
TL;DR: This chapter introduces the updated understandings of metabolic reprogramming of immune cells in the TME and suggests new directions in manipulation of immune responses for cancer diagnosis and therapy.
Journal ArticleDOI
Lung cancer cells release high mobility group box 1 and promote the formation of neutrophil extracellular traps.
Jiawei Zhou,Yonglin Yang,Tingting Gan,Yan Li,Fan Hu,Nannan Hao,Baorui Yuan,Yu Chen,Mingshun Zhang +8 more
TL;DR: It was identified that Lewis lung carcinoma cells actively released the danger-associated molecular pattern protein high mobility group box 1 (HMGB1) in lung cancer cell supernatants, which promoted the formation of neutrophil extracellular traps (NETs), which was dependent on Toll-like receptor 4 (TLR4).
Journal ArticleDOI
Polypharmacological Profiles Underlying the Antitumor Property of Salvia miltiorrhiza Root (Danshen) Interfering with NOX-Dependent Neutrophil Extracellular Traps.
Li Tao,Min Xu,Xiaojun Dai,Tengyang Ni,Dan Li,Feng Jin,Haibo Wang,Lide Tao,Bo Pan,James R. Woodgett,James R. Woodgett,Yayun Qian,Yanqing Liu +12 more
TL;DR: Insight is provided into how promiscuous compounds from herbal medicine can be effectively targeted NETs towards hematogenous metastasis of certain tumors.
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