Nonvascular VEGF receptor 3 expression by corneal epithelium maintains avascularity and vision.
Claus Cursiefen,Lu Chen,Magali Saint-Geniez,Pedram Hamrah,Yiping Jin,Saadia Rashid,Bronislaw Pytowski,Kris Persaud,Yan Wu,J. Wayne Streilein,Reza Dana +10 more
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TLDR
Evidence is provided for a critical mechanism contributing to corneal avascularity, VEGF receptor 3, normally present on lymphatic and proliferating blood vascular endothelium, is strongly constitutively expressed by Corneal epithelium and is mechanistically responsible for suppressing inflammatory cornea angiogenesis.Abstract:
Transparency of the cornea, the window of the eye, is a prerequisite for vision. Angiogenesis into the normally avascular cornea is incompatible with good vision and, therefore, the cornea is one of the few tissues in the human body where avascularity is actively maintained. Here, we provide evidence for a critical mechanism contributing to corneal avascularity. VEGF receptor 3, normally present on lymphatic and proliferating blood vascular endothelium, is strongly constitutively expressed by corneal epithelium and is mechanistically responsible for suppressing inflammatory corneal angiogenesis.read more
Citations
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Dry Eye as a Mucosal Autoimmune Disease
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Ocular surface immunity: homeostatic mechanisms and their disruption in dry eye disease.
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Immune Privilege and Angiogenic Privilege of the Cornea
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Bevacizumab (Avastin) eye drops inhibit corneal neovascularization.
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David Ellenberg,Dimitri T. Azar,Joelle A. Hallak,Faisal M. Tobaigy,Kyu Yeon Han,Sandeep Jain,Zhongjun Zhou,Jin Hong Chang +7 more
TL;DR: The results of experimental studies demonstrating that corneal avascularity is an active process involving the production of anti-angiogenic factors, which counterbalance the pro-ANGiogenic/lymphangiogenesis factors that are upregulated during wound healing are provided.
References
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Arja Kaipainen,Jaana Korhonen,Tuija Mustonen,Victor W.M. van Hinsbergh,Guo-Hua Fang,Daniel J. Dumont,Martin L. Breitman,Kari Alitalo +7 more
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VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment
Claus Cursiefen,Lu Chen,Leonardo P. Borges,David A. Jackson,Jingtai Cao,Czeslaw Radziejewski,Patricia A. D'Amore,Reza Dana,Stanley J. Wiegand,J. Wayne Streilein +9 more
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