Journal ArticleDOI
Nrf2-p62 autophagy pathway and its response to oxidative stress in hepatocellular carcinoma.
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TLDR
Emerging molecular mechanisms and the therapeutic perspective of targeting Nrf2‐p62 interaction in HCC are discussed in this paper along with the prognostic value of autophagy in this type of cancer.About:
This article is published in Translational Research.The article was published on 2017-11-01. It has received 139 citations till now. The article focuses on the topics: Autophagy & KEAP1.read more
Citations
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Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease.
TL;DR: This review summarizes the mechanisms that may account for the excessive production of ROS, the potential mechanistic roles of ROS that drive NAFLD progression, and therapeutic interventions that are related to oxidative stress.
Journal ArticleDOI
Molecular Mechanisms Driving Progression of Liver Cirrhosis towards Hepatocellular Carcinoma in Chronic Hepatitis B and C Infections: A Review
TL;DR: The literature suggests that genetic and epigenetic factors play a role in liver cirrhosis and its progression to HCC, and that HBV- and HCV-encoded proteins appear to be involved in hepatocarcinogenesis.
Journal ArticleDOI
Dysregulation of Nrf2 in Hepatocellular Carcinoma: Role in Cancer Progression and Chemoresistance.
TL;DR: The role and mechanism(s) of action of Nrf2 dysregulation in HCC and therapeutic options that can be employed to modulate this transcription factor are summarized.
Journal ArticleDOI
Lipidomic biomarkers and mechanisms of lipotoxicity in non-alcoholic fatty liver disease.
Gianluca Svegliati-Baroni,I. Pierantonelli,Pierangelo Torquato,Rita Marinelli,Carla Ferreri,Chryssostomos Chatgilialoglu,Desirée Bartolini,Francesco Galli +7 more
TL;DR: Accumulating data indicate that the total amount of triglycerides stored in hepatocytes is not the major determinant of lipotoxicity and that specific lipid classes act as damaging agents on liver cells.
Journal ArticleDOI
Autophagy in liver diseases: A review.
TL;DR: The liver is a highly dynamic metabolic organ that plays critical roles in plasma protein synthesis, gluconeogenesis and glycogen storage, cholesterol metabolism and bile acid synthesis as well as drug/xenobiotic metabolism and detoxification as discussed by the authors.
References
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Journal ArticleDOI
Sorafenib in Advanced Hepatocellular Carcinoma
Josep M. Llovet,Sergio Ricci,Vincenzo Mazzaferro,Philip Hilgard,Edward Gane,Jean-Frédéric Blanc,André Cosme de Oliveira,Armando Santoro,Jean-Luc Raoul,Alejandro Forner,Myron Schwartz,Camillo Porta,Stefan Zeuzem,Luigi Bolondi,Tim F. Greten,Peter R. Galle,Jean Francois Seitz,Ivan Borbath,Dieter Häussinger,Tom Giannaris,Minghua Shan,M. Moscovici,D. Voliotis,Jordi Bruix +23 more
TL;DR: In patients with advanced hepatocellular carcinoma, median survival and the time to radiologic progression were nearly 3 months longer for patients treated with sorafenib than for those given placebo.
Journal ArticleDOI
Management of hepatocellular carcinoma: An update
Jordi Bruix,Morris Sherman +1 more
TL;DR: The American Association for the Study of Liver Diseases (AASLD) practice guidelines on the management of hepatocellular carcinoma (HCC) were updated in 2010 as discussed by the authors.
AASLD PRACTICE GUIDELINE Management of Hepatocellular Carcinoma: An Update
Jordi Bruix,Morris Sherman +1 more
TL;DR: Since the publication of the American Association for the Study of Liver Diseases (AASLD) practice guidelines on the management of hepatocellular carcinoma (HCC) in 2005, new information has emerged that requires that the guidelines be updated.
Journal ArticleDOI
Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple.
TL;DR: Estimates can be used to more fully understand the redox biochemistry that results from oxidative stress, which hopefully will provide a rationale and understanding of the cellular mechanisms associated with cell growth and development, signaling, and reductive or oxidative stress.
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