Obesity Is Associated With Pulmonary Hypertension and Modifies Outcomes.
Rachel C. Frank,Jeff Min,Mazin T Abdelghany,Samantha M. Paniagua,Romit Bhattacharya,Vijeta Bhambhani,Eugene Pomerantsev,Jennifer E. Ho +7 more
TLDR
Obesity is independently associated with pulmonary hypertension and PH is associated with greater mortality; this is modified by obesity such that obese patients with precapillary PH have lower mortality compared with nonobese counterparts.Abstract:
Background Experimental studies support a link between obesity and pulmonary hypertension (PH), yet clinical studies have been limited. This study sought to determine the association of obesity and...read more
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Obesity Cardiomyopathy: Evidence, Mechanisms and Therapeutic Implications.
TL;DR: In this article, a review of the evidence for obesity cardiomyopathy is presented, examining putative responsible mechanisms, and discusses therapeutic options for this disorder, which develops independent of hypertension, coronary heart disease, and other heart diseases.
Journal ArticleDOI
Single-cell profiling of vascular endothelial cells reveals progressive organ-specific vulnerabilities during obesity
Olga Bondareva,Jesús Rafael Rodríguez-Aguilera,F. Oliveira,Longsheng Liao,Alina Rose,Anubhuti Sharma and Priti Gupta,Kunal Kumar Singh,Florian Geier,Jenny Schuster,Jes Niels Boeckel,Joerg Martin Buescher,Shrey Kohli,Nora Klöting,Berend Isermann,Matthias Blüher,B. Sheikh +15 more
TL;DR: In this article , the authors used single-cell RNA sequencing to analyze transcriptomes of ~375,000 ECs from seven organs in male mice at progressive stages of obesity to identify organ-specific vulnerabilities.
Journal ArticleDOI
Pulmonary Arterial Pruning and Longitudinal Change in Percent Emphysema and Lung Function: The Genetic Epidemiology of COPD Study.
Carrie L. Pistenmaa,P. Nardelli,Samuel Y. Ash,Carolyn E. Come,A.A. Diaz,Farbod N. Rahaghi,R.G. Barr,K.A. Young,G.L. Kinney,J.P. Simmons,R.C. Wade,James M. Wells,J.E. Hokanson,G.R. Washko,R. San Jose Estepar,James D. Crapo,Edwin K. Silverman,Barry J. Make,Elizabeth A. Regan,Terri H. Beaty,Peter J. Castaldi,Michael H. Cho,Dawn L. DeMeo,Adel El Boueiz,Marilyn G. Foreman,Auyon J. Ghosh,Lystra P. Hayden,C.P. Hersh,Jacqueline B. Hetmanski,Brian D. Hobbs,John E. Hokanson,Wonji Kim,Nan M. Laird,Christoph Lange,Sharon M. Lutz,Merry-Lynn McDonald,Dmitry Prokopenko,Matthew Moll,Jarrett D. Morrow,Dandi Qiao,Aabida Saferali,Phuwanat Sakornsakolpat,Emily S. Wan,Jeong H. Yun,Juan Pablo Centeno,Jean-Paul Charbonnier,Harvey O. Coxson,Craig J. Galban,MeiLan K. Han,Eric A. Hoffman,Stephen M. Humphries,Francine L. Jacobson,Philip F. Judy,Ella A. Kazerooni,Alex Kluiber,David A. Lynch,Pietro Nardelli,John D. Newell,Aleena M. Notary,Andrea S Oh,James C. Ross,Raúl San José Estépar,Joyce D. Schroeder,Jered Sieren,Berend C. Stoel,Juerg Tschirren,Edwin J R van Beek,Bramvan Ginneken,Eva M. van Rikxoort,Gonzalo Vegas Sanchez Ferrero,Lucas Veitel,George R. Washko,Carla Wilson,Robert L. Jensen,Douglas Everett,Jim Crooks,Katherine A. Pratte,Matthew Strand,Erin Austin,Gregory L. Kinney,Kendra A. Young,Surya P. Bhatt,Jessica Bon,Alejandro A. Diaz,Barry J. Make,Susan Murray,E.A. Regan,Xavier Soler,Russell P. Bowler,Katerina Kechris,Farnoush Banaei-Kashani,Jeffrey L. Curtis,Perry G. Pernicano,Nicola A. Hanania,Mustafa A. Atik,Aladin M. Boriek,Kalpatha Guntupalli,Elizabeth Guy,Amit D. Parulekar,Craig P. Hersh,George R. Washko,R. Graham Barr,John H. M. Austin,Belinda D’Souza,Byron Thomashow,Neil R. MacIntyre,H. Page McAdams,Lacey Washington,Charlene McEvoy,Joseph H. Tashjian,Robert A. Wise,Robert H. Brown,Nadia N. Hansel,Karen M. Horton,Allison A. Lambert,Nirupama Putcha,Richard Casaburi,Alessandra Adami,Matthew J. Budoff,Hans Fischer,Janos Porszasz,Harry B. Rossiter,William W. Stringer,Amir Sharafkhaneh,Charlie Lan,Christine H. Wendt,Brian Bell,Ken M. Kunisaki,Eric Flenaugh,Hirut T. Gebrekristos,Mario Ponce,Silanath Terpenning,Gloria Westney,Russell P. Bowler,Richard Rosiello,David Pace,Gerard J. Criner,David Ciccolella,Francis Cordova,Chandra Dass,Gilbert E. D'Alonzo,Parag Desai,Michael R. Jacobs,Steven G. Kelsen,Victor Kim,A. James Mamary,Nathaniel Marchetti,Aditi Satti,Kartik Shenoy,Robert M. Steiner,Alex Swift,Irene Swift,Maria Elena Vega-Sanchez,Mark T. Dransfield,William C. Bailey,Anand S Iyer,Hrudaya Nath,J. Michael Wells,Douglas Conrad,Andrew Yen,Alejandro P. Comellas,Karin F. Hoth,John Newell,Brad H. Thompson,Ella A. Kazerooni,Wassim W. Labaki,Craig J. Galbán,Dharshan Vummidi,Joanne Billings,Abbie Begnaud,Tadashi Allen,Frank C. Sciurba,Divay Chandra,Joel L. Weissfeld +173 more
TL;DR: For instance, the authors found that pulmonary arterial pruning was associated with faster progression of emphysema and more rapid decline in FEV1 to FVC ratio over 5 years in ever smokers.
Journal ArticleDOI
BMI Is Causally Associated With Pulmonary Artery Pressure But Not Hemodynamic Evidence of Pulmonary Vascular Remodeling
Timothy E. Thayer,Rebecca T. Levinson,Shi Huang,Tufik R. Assad,Eric Farber-Eger,Quinn S. Wells,Jonathan D. Mosley,Evan L. Brittain +7 more
TL;DR: Mendelian randomization of the BMI_sGRS supported that higher BMI is causal of higher systolic pulmonary artery pressure (sPAP), and sensitivity analyses showed sPAP∼BMI_SGRS relationship was preserved when either PAH or PVH individuals were excluded.
Journal ArticleDOI
Idiopathic pulmonary arterial hypertension patients with a high H2FPEF-score: Insights from the Amsterdam UMC PAH-cohort.
Azar Kianzad,Jessie van Wezenbeek,Luca Celant,Frank P. T. Oosterveer,Anton Vonk-Noordegraaf,Lilian J. Meijboom,Frances S. de Man,Harm Jan Bogaard,M. Louis Handoko +8 more
TL;DR: In this paper , the authors performed a retrospective analysis of 253 treatment-naïve idiopathic pulmonary arterial hypertension (iPAH) patients with a confirmed diagnosis after right heart catheterization by a multidisciplinary team.
References
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Journal ArticleDOI
Haemodynamic definitions and updated clinical classification of pulmonary hypertension.
Gérald Simonneau,Gérald Simonneau,David Montani,David Montani,David S. Celermajer,Christopher P. Denton,Michael A. Gatzoulis,Michael J. Krowka,Paul G. Williams,Rogério Souza +9 more
TL;DR: The 6th WSPH Task Force proposed to include pulmonary vascular resistance ≥3 Wood Units in the definition of all forms of pre-capillary PH associated with mPAP >20 mmHg, and included in group 1 of a subgroup “pulmonary arterial hypertension (PAH) long-term responders to calcium channel blockers”.
Journal Article
Prevalence of Obesity Among Adults and Youth: United States, 2011-2014.
TL;DR: This report provides the most recent national data on obesity prevalence by sex, age, and race and Hispanic origin, using data for 2011- 2014.
Journal ArticleDOI
Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction: A Community-Based Study
Carolyn S.P. Lam,Véronique L. Roger,Richard J. Rodeheffer,Barry A. Borlaug,Felicity Enders,Margaret M. Redfield +5 more
TL;DR: Although pulmonary venous HTN contributes to PH, it does not fully account for the severity of PH in HFpEF, suggesting that a component of pulmonary arterial HTN also contributes.
Journal ArticleDOI
Phenomapping for novel classification of heart failure with preserved ejection fraction.
Sanjiv J. Shah,Daniel H. Katz,Senthil Selvaraj,Michael A. Burke,Clyde W. Yancy,Mihai Gheorghiade,Robert O. Bonow,Chiang Ching Huang,Rahul C. Deo +8 more
TL;DR: In this article, the authors evaluated whether unbiased clustering analysis using dense phenotypic data (phenomapping) could identify phenotypically distinct heart failure with preserved ejection fraction (HFpEF) categories.
Journal ArticleDOI
Clinical Correlates and Reference Intervals for Pulmonary Artery Systolic Pressure Among Echocardiographically Normal Subjects
TL;DR: Findings support the use of age- and BMI-corrected values in establishing the expected normal range for PASP, which was associated with age, BMI, sex, wall thickness, and ejection fraction among 3790 echocardiographically normal subjects.