Journal ArticleDOI
One-year supplementation with a grape extract containing resveratrol modulates inflammatory-related microRNAs and cytokines expression in peripheral blood mononuclear cells of type 2 diabetes and hypertensive patients with coronary artery disease.
Joao Tomé-Carneiro,Mar Larrosa,María J. Yáñez-Gascón,Alberto Dávalos,Judit Gil-Zamorano,Manuel Gonzálvez,Francisco J. García-Almagro,José A. Ruiz Ros,Francisco A. Tomás-Barberán,Juan Carlos Espín,María-Teresa García-Conesa +10 more
TLDR
Preliminary evidence is provided that long-term supplementation with a grape extract containing RES downregulates the expression of key pro-inflammatory cytokines with the involvement of inflammation-related miRs in circulating immune cells of T2DM hypertensive medicated patients and support a beneficial immunomodulatory effect in these patients.About:
This article is published in Pharmacological Research.The article was published on 2013-06-01. It has received 306 citations till now. The article focuses on the topics: Inflammation & Peripheral blood mononuclear cell.read more
Citations
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Journal ArticleDOI
Novel insights of dietary polyphenols and obesity.
Shu Wang,Naima Moustaid-Moussa,Lixia Chen,Huanbiao Mo,Anuradha Shastri,Rui Su,Priyanka Bapat,In Sook Kwun,Chwan-Li Shen +8 more
TL;DR: Animal studies strongly suggest that commonly consumed polyphenols described in this review have a pronounced effect on obesity as shown by lower body weight, fat mass and triglycerides through enhancing energy expenditure and fat utilization, and modulating glucose hemostasis.
Journal ArticleDOI
Bioavailability, bioactivity and impact on health of dietary flavonoids and related compounds: an update
Ana Rodriguez-Mateos,David Vauzour,Christian G. Krueger,Dhanansayan Shanmuganayagam,Jess D. Reed,Luca Calani,Pedro Mena,Daniele Del Rio,Alan Crozier +8 more
TL;DR: Recent findings on the bioavailability and biological activity of (poly)phenols are summarized, focusing on the epidemiological and clinical evidence of beneficial effects of flavonoids and related compounds on urinary tract infections, cognitive function and age-related cognitive decline, cancer and cardiovascular disease.
Journal ArticleDOI
Obesity-associated oxidative stress: strategies finalized to improve redox state.
TL;DR: Current concepts in the meaning of obesity as a state of chronic oxidative stress and the potential interventions to improve redox balance are described.
Journal ArticleDOI
Antioxidant effects of resveratrol in the cardiovascular system
TL;DR: The antioxidant effects of resveratrol (3,5,4'‐trihydroxy‐trans‐stilbene) contribute substantially to the health benefits of this compound and are more likely to be attributable to its effect as a gene regulator.
Journal ArticleDOI
Resveratrol and Cardiovascular Diseases.
TL;DR: The discussions on potential beneficial effects of RES in CVDs should compare the results of preclinical studies with those of clinical trials, and difficulties in the interpretation of results arise from the use of high-dose RES supplements in research studies, whereas low RES concentrations are present in red wine.
References
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A new mathematical model for relative quantification in real-time RT-PCR.
TL;DR: This study enters into the particular topics of the relative quantification in real-time RT-PCR of a target gene transcript in comparison to a reference gene transcript and presents a new mathematical model that needs no calibration curve.
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Insights into the regulation of protein abundance from proteomic and transcriptomic analyses
TL;DR: Current understanding of the major factors regulating protein expression is summarized to demonstrate a substantial role for regulatory processes occurring after mRNA is made in controlling steady-state protein abundances.
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miRWalk - Database: Prediction of possible miRNA binding sites by walking the genes of three genomes
TL;DR: The miRWalk database as mentioned in this paper is a comprehensive database on miRNAs, which hosts predicted as well as validated miRNA binding sites, information on all known genes of human, mouse and rat.
Journal ArticleDOI
Pervasive roles of microRNAs in cardiovascular biology
Eric M. Small,Eric N. Olson +1 more
TL;DR: The wideranging functions of microRNAs in the cardiovascular system have provided new perspectives on disease mechanisms and have revealed intriguing therapeutic targets, as well as diagnostics, for a variety of cardiovascular disorders.
Journal ArticleDOI
Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans
Silvie Timmers,Ellen Konings,L. Bilet,Riekelt H. Houtkooper,Tineke van de Weijer,Gijs H. Goossens,Joris Hoeks,Sophie E. van der Krieken,Dongryeol Ryu,Sander Kersten,Esther Moonen-Kornips,Matthijs K. C. Hesselink,Iris Kunz,Vera B. Schrauwen-Hinderling,Ellen E. Blaak,Johan Auwerx,Patrick Schrauwen +16 more
TL;DR: It is demonstrated that 30 days of resveratrol supplementation induces metabolic changes in obese humans, mimicking the effects of calorie restriction.
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Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans
Silvie Timmers,Ellen Konings,L. Bilet,Riekelt H. Houtkooper,Tineke van de Weijer,Gijs H. Goossens,Joris Hoeks,Sophie E. van der Krieken,Dongryeol Ryu,Sander Kersten,Esther Moonen-Kornips,Matthijs K. C. Hesselink,Iris Kunz,Vera B. Schrauwen-Hinderling,Ellen E. Blaak,Johan Auwerx,Patrick Schrauwen +16 more