Journal ArticleDOI
Ontogeny and mechanisms of action for the stimulatory effect of kisspeptin on gonadotropin-releasing hormone system of the rat.
Juan M. Castellano,Víctor M. Navarro,R. Fernández-Fernández,Justo P. Castaño,María M. Malagón,Enrique Aguilar,Carlos Dieguez,Paolo Magni,Leonor Pinilla,Manuel Tena-Sempere +9 more
Reads0
Chats0
TLDR
The present data document the ontogeny, sensitivity and intracellular signals for the stimulatory action of kisspeptin on the GnRH/LH axis in the rat and stress the essential role ofkisspeptin in normal, and eventually pathological, timing of puberty.About:
This article is published in Molecular and Cellular Endocrinology.The article was published on 2006-09-26. It has received 173 citations till now. The article focuses on the topics: Kisspeptin & Gonadotropin-releasing hormone.read more
Citations
More filters
Journal ArticleDOI
Kisspeptin-immunoreactivity changes in a sex- and hypothalamic-region-specific manner across rat postnatal development.
TL;DR: The present study highlights the expression of hypothalamic kisspeptins soon after birth, as well as the neonatal establishment of a strong and persisting sex difference in ARC kisspeptin‐IR in rats.
Journal ArticleDOI
The kisspeptin receptor: A key G-protein-coupled receptor in the control of the reproductive axis.
TL;DR: A succinct summary of some of the most salient facets of Kiss1R, as essential GPCR for the proper maturation and function of the reproductive axis is provided.
Journal ArticleDOI
Kisspeptin antagonist prevents RF9-induced reproductive changes in female rats
TL;DR: Kisspeptin antagonist, p234, modulates the effects of kisspeptin on reproductive functions and energy balance, whereas RF9 seems to exert only its effects on Reproductive functions by means of GPR54 signaling in female rats.
Journal ArticleDOI
Photoperiodic regulation of puberty in seasonal species.
TL;DR: It is hypothesized that at puberty and seasonal reoccurrences of fertility it is the changing local levels of thyroid hormone that orchestrate hypothalamic plasticity, ultimately impinging upon the secretion of GnRH.
Journal ArticleDOI
Kisspeptin-10 elicits triphasic cytosolic calcium responses in immortalized GT1-7 GnRH neurones
TL;DR: The compatibility of appeared mirrored-patterns of kisspeptin-10-induced changes in [Ca(2+)](i) concentrations in these neurons and GnRH secretion confirm the importance of intracellular calcium flux downstream from GPR54 through PKC signaling pathway.
References
More filters
Book
The Physiology of Reproduction
Ernst Knobil,J. D. Neill +1 more
TL;DR: The gametes, fertilization and early embryogenesis the reproductive systems - the female, the male the pituitary and the hypothalmus, and the reproductive processes and their control.
Journal ArticleDOI
SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase
Brydon L. Bennett,Dennis T. Sasaki,Brion W. Murray,Eoin C. O'leary,Steve T. Sakata,Weiming Xu,Jim C. Leisten,Aparna Motiwala,Steve Pierce,Yoshitaka Satoh,Shripad S. Bhagwat,Anthony M. Manning,David W. Anderson +12 more
TL;DR: SP600125 blocked (bacterial) lipopolysaccharide-induced expression of tumor necrosis factor-α and inhibited anti-CD3-induced apoptosis of CD4+ CD8+ thymocytes and supports targeting JNK as an important strategy in inflammatory disease, apoptotic cell death, and cancer.
Journal ArticleDOI
The GPR54 gene as a regulator of puberty
Stephanie B. Seminara,Sophie Messager,Emmanouella E. Chatzidaki,Rosemary R. Thresher,James S. Acierno,Jenna K. Shagoury,Yousef Bo-Abbas,Wendy Kuohung,Kristine M. Schwinof,Alan G. Hendrick,Dirk Zahn,John Dixon,Ursula B. Kaiser,Susan A. Slaugenhaupt,James F. Gusella,Stephen O'Rahilly,Mark Carlton,William F. Crowley,Samuel Aparicio,William H. Colledge +19 more
TL;DR: Puberty is initiated when gonadotropin-releasing hormone begins to be secreted by the hypothalamus, and complementary genetic approaches in humans and mice identified genetic factors that determine the onset of puberty.
Journal ArticleDOI
Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54
Nicolas de Roux,Emmanuelle Génin,Jean Claude Carel,Fumihiko Matsuda,Chaussain Jl,Edwin Milgrom +5 more
TL;DR: The present study shows that loss of function of GPR54 is a cause of IHH, and it identifies GPR 54 and possibly KiSS1 protein-derived peptide as playing a major and previously unsuspected role in the physiology of the gonadotropic axis.
Journal ArticleDOI
SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1
Ana Cuenda,John Rouse,Yair N. Doza,Roger Meier,Philip Cohen,Timothy Francis Gallagher,Peter R. Young,John C. Lee +7 more
TL;DR: It is established that MAPKAP kinase‐2 is a physiological RK substrate, and that HSP27 is phosphorylated by MAPK AP kinase-2 in vivo.
Related Papers (5)
The GPR54 gene as a regulator of puberty
Stephanie B. Seminara,Sophie Messager,Emmanouella E. Chatzidaki,Rosemary R. Thresher,James S. Acierno,Jenna K. Shagoury,Yousef Bo-Abbas,Wendy Kuohung,Kristine M. Schwinof,Alan G. Hendrick,Dirk Zahn,John Dixon,Ursula B. Kaiser,Susan A. Slaugenhaupt,James F. Gusella,Stephen O'Rahilly,Mark Carlton,William F. Crowley,Samuel Aparicio,William H. Colledge +19 more