Journal ArticleDOI
Ontogeny and mechanisms of action for the stimulatory effect of kisspeptin on gonadotropin-releasing hormone system of the rat.
Juan M. Castellano,Víctor M. Navarro,R. Fernández-Fernández,Justo P. Castaño,María M. Malagón,Enrique Aguilar,Carlos Dieguez,Paolo Magni,Leonor Pinilla,Manuel Tena-Sempere +9 more
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TLDR
The present data document the ontogeny, sensitivity and intracellular signals for the stimulatory action of kisspeptin on the GnRH/LH axis in the rat and stress the essential role ofkisspeptin in normal, and eventually pathological, timing of puberty.About:
This article is published in Molecular and Cellular Endocrinology.The article was published on 2006-09-26. It has received 173 citations till now. The article focuses on the topics: Kisspeptin & Gonadotropin-releasing hormone.read more
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Evidence for two distinct KiSS genes in non-placental vertebrates that encode kisspeptins with different gonadotropin-releasing activities in fish and mammals
Alicia Felip,Silvia Zanuy,Rafael Pineda,Leonor Pinilla,Manuel Carrillo,Manuel Tena-Sempere,Ana M. Gómez +6 more
TL;DR: The data are the first to provide conclusive evidence for the existence of a second KiSS gene, KiSS-2, in non-placental vertebrates, whose product is likely to play a dominant stimulatory role in the regulation of the gonadotropic axis at least in teleosts.
Journal ArticleDOI
Direct pituitary effects of kisspeptin: activation of gonadotrophs and somatotrophs and stimulation of luteinising hormone and growth hormone secretion.
Ester Gutiérrez-Pascual,Antonio J. Martínez-Fuentes,Leonor Pinilla,Manuel Tena-Sempere,María M. Malagón,Justo P. Castaño +5 more
TL;DR: Results provide unequivocal evidence that kisspeptins exert direct pituitary effects in peripubertal male and female rats and suggest a possible autocrine/paracrine mode of action.
Journal ArticleDOI
The role of kisspeptin in the control of gonadotrophin secretion
TL;DR: Findings in the KiSS-1/gpr-54 system are highlighted, focusing on their regulation of the HPG axis in male and female reproductive systems of both mammalian and non-mammalian vertebrates.
Journal ArticleDOI
Metabolic control of puberty: roles of leptin and kisspeptins.
TL;DR: Experimental evidence supporting a role of leptin, kisspeptin and putatively related pathways in the concerted control of puberty by energy balance and metabolism is critically reviewed.
Journal ArticleDOI
The Kisspeptin/Gonadotropin-Releasing Hormone Pathway and Molecular Signaling of Puberty in Fish
TL;DR: Temporal patterns of expression in the brain of kiss1r, gnrh2, and gnrh3 and a suite of related genes in the hypothalamo-pituitary-gonadal (HPG) axis were determined and elevated expression of esr1, ar, and cyp19a2 (genes involved in sex steroid signaling) in thebrain at the onset of puberty, and in females slightly in advance of the elevation in the expression ofkiss1r.
References
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Book
The Physiology of Reproduction
Ernst Knobil,J. D. Neill +1 more
TL;DR: The gametes, fertilization and early embryogenesis the reproductive systems - the female, the male the pituitary and the hypothalmus, and the reproductive processes and their control.
Journal ArticleDOI
SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase
Brydon L. Bennett,Dennis T. Sasaki,Brion W. Murray,Eoin C. O'leary,Steve T. Sakata,Weiming Xu,Jim C. Leisten,Aparna Motiwala,Steve Pierce,Yoshitaka Satoh,Shripad S. Bhagwat,Anthony M. Manning,David W. Anderson +12 more
TL;DR: SP600125 blocked (bacterial) lipopolysaccharide-induced expression of tumor necrosis factor-α and inhibited anti-CD3-induced apoptosis of CD4+ CD8+ thymocytes and supports targeting JNK as an important strategy in inflammatory disease, apoptotic cell death, and cancer.
Journal ArticleDOI
The GPR54 gene as a regulator of puberty
Stephanie B. Seminara,Sophie Messager,Emmanouella E. Chatzidaki,Rosemary R. Thresher,James S. Acierno,Jenna K. Shagoury,Yousef Bo-Abbas,Wendy Kuohung,Kristine M. Schwinof,Alan G. Hendrick,Dirk Zahn,John Dixon,Ursula B. Kaiser,Susan A. Slaugenhaupt,James F. Gusella,Stephen O'Rahilly,Mark Carlton,William F. Crowley,Samuel Aparicio,William H. Colledge +19 more
TL;DR: Puberty is initiated when gonadotropin-releasing hormone begins to be secreted by the hypothalamus, and complementary genetic approaches in humans and mice identified genetic factors that determine the onset of puberty.
Journal ArticleDOI
Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54
Nicolas de Roux,Emmanuelle Génin,Jean Claude Carel,Fumihiko Matsuda,Chaussain Jl,Edwin Milgrom +5 more
TL;DR: The present study shows that loss of function of GPR54 is a cause of IHH, and it identifies GPR 54 and possibly KiSS1 protein-derived peptide as playing a major and previously unsuspected role in the physiology of the gonadotropic axis.
Journal ArticleDOI
SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1
Ana Cuenda,John Rouse,Yair N. Doza,Roger Meier,Philip Cohen,Timothy Francis Gallagher,Peter R. Young,John C. Lee +7 more
TL;DR: It is established that MAPKAP kinase‐2 is a physiological RK substrate, and that HSP27 is phosphorylated by MAPK AP kinase-2 in vivo.
Related Papers (5)
The GPR54 gene as a regulator of puberty
Stephanie B. Seminara,Sophie Messager,Emmanouella E. Chatzidaki,Rosemary R. Thresher,James S. Acierno,Jenna K. Shagoury,Yousef Bo-Abbas,Wendy Kuohung,Kristine M. Schwinof,Alan G. Hendrick,Dirk Zahn,John Dixon,Ursula B. Kaiser,Susan A. Slaugenhaupt,James F. Gusella,Stephen O'Rahilly,Mark Carlton,William F. Crowley,Samuel Aparicio,William H. Colledge +19 more