Pathogenesis of COVID-19 from a cell biology perspective.
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TLDR
COVID-19 can be understood by the region of the lung that is infected and can be divided into three phases that correspond to different clinical stages of the disease, which will be confined to the conducting airways and severe disease will involve the gas exchange portion of the lungs.Abstract:
COVID-19 can be understood by the region of the lung that is infected. Mild disease will be confined to the conducting airways and severe disease will involve the gas exchange portion of the lung.read more
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Imaging related to underlying immunological and pathological processes in COVID-19
E. Ilieva,Alexandra Boyapati,Lyubomir Georgiev Chervenkov,Milena Gulinac,Jordan Borisov,Kamelia Genova,Tsvetelina Velikova +6 more
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MNAD Hypothesis Based Protocol Proposed for Treatment of COVID.19: Assessment of Minocycline, N. acetylcysteine, Aspirin & vitamin D (MNad) Theory for treatment of COVID.19 Adults Patients
Mosab Nouraldein Mohammed Hamad,Mohammed Abdelgafoor Abdelgadir Salih,Mohammed Omer Mohammed Hussein,Sufian Khalid Mohammed Nor,Haifaa Mohamed Saeed,Fatima Omer Mohamed +5 more
TL;DR: MAD hypothesis based protocol aimed to measure validity of combination Minocycline as antibiotic, N. acetyl cysteine as antioxidant, aspirin as anticoagulant and vitamin D as immune regulator to treat COVID.19 infection.
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Pneumomediastinum, pneumopericardium, and subcutaneous emphysema—a rare complication in COVID-19 infection
TL;DR: In this paper, a case of spontaneous pneumomediastinum, pneumopericardium, and subcutaneous emphysema in a 62-year-old diabetic patient with COVID-19 infection who presented with cough, fever, and breathlessness, which turned to be a fatal complication.
Journal ArticleDOI
A narrative review of non-pharmacological management of SARS-CoV-2 respiratory failure: A call for an evidence based approach
TL;DR: The need for an evidence-based approach to the management of COVID-19 related ARDS is re-emphasized and treatment strategies that have been established after rigorous trials and have stood the test of time are reviewed.
Journal ArticleDOI
Brief Report: Rapid Clinical Recovery From Critical Coronavirus Disease 2019 With Respiratory Failure in a Pregnant Patient Treated With IV Vasoactive Intestinal Peptide
TL;DR: Aviptadil, a synthetic form of human vasoactive intestinal peptide, has entered clinical trials to treat critical coronavirus disease 2019 pneumonia with respiratory failure as discussed by the authors .
References
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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Markus Hoffmann,Hannah Kleine-Weber,Simon Schroeder,Nadine Krüger,Tanja Herrler,Sandra Erichsen,Tobias S. Schiergens,Georg Herrler,Nai Huei Wu,Andreas Nitsche,Marcel A. Müller,Christian Drosten,Christian Drosten,Stefan Pöhlmann +13 more
TL;DR: It is demonstrated that SARS-CoV-2 uses the SARS -CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming, and it is shown that the sera from convalescent SARS patients cross-neutralized Sars-2-S-driven entry.
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Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention
Zunyou Wu,Jennifer M. McGoogan +1 more
TL;DR: Hospitalised COVID-19 patients are frequently elderly subjects with co-morbidities receiving polypharmacy, all of which are known risk factors for d
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Pathological findings of COVID-19 associated with acute respiratory distress syndrome.
Zhe Xu,Lei Shi,Yijin Wang,Ji-Yuan Zhang,Lei Huang,Chao Zhang,Shuhong Liu,Peng Zhao,Hongxia Liu,Li Zhu,Yanhong Tai,Changqing Bai,Tingting Gao,Jin-Wen Song,Peng Xia,Jing-Hui Dong,Jingmin Zhao,Fu-Sheng Wang +17 more
TL;DR: O surto do novo coronavÃrus (COVID-19) em Wuhan, China, iniciado em dezembro de 2019, evoluiu para se tornar uma pandemia global A.
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Receptor Recognition by the Novel Coronavirus from Wuhan: an Analysis Based on Decade-Long Structural Studies of SARS Coronavirus.
TL;DR: These analyses provide insights into the receptor usage, cell entry, host cell infectivity and animal origin of 2019-nCoV and may help epidemic surveillance and preventive measures against 2019- nCoV.
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Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis.
Paul A. Reyfman,James M. Walter,Nikita Joshi,Kishore R. Anekalla,Alexandra C. McQuattie-Pimentel,Stephen Chiu,Ramiro Fernandez,Mahzad Akbarpour,Ching I. Chen,Ziyou Ren,Rohan Verma,Hiam Abdala-Valencia,Kiwon Nam,Monica Chi,SeungHye Han,Francisco J. Gonzalez-Gonzalez,Saul Soberanes,Satoshi Watanabe,Kinola J.N. Williams,Annette S. Flozak,Trevor T. Nicholson,Vince K. Morgan,Deborah R. Winter,Monique Hinchcliff,Cara L. Hrusch,Robert D. Guzy,Catherine A. Bonham,Anne I. Sperling,Remzi Bag,Robert B. Hamanaka,Gökhan M. Mutlu,Anjana Yeldandi,Stacy A. Marshall,Ali Shilatifard,Luís A. Nunes Amaral,Harris Perlman,Jacob I. Sznajder,A. Christine Argento,Colin T. Gillespie,Jane Dematte,Manu Jain,Benjamin D. Singer,Karen M. Ridge,Anna P. Lam,Ankit Bharat,Sangeeta Bhorade,Cara J. Gottardi,G. R. Scott Budinger,Alexander V. Misharin +48 more
TL;DR: The results support the feasibility of discovery-based approaches using next-generation sequencing technologies to identify signaling pathways for targeting in the development of personalized therapies for patients with pulmonary fibrosis.
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