Pathogenesis of COVID-19 from a cell biology perspective.
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TLDR
COVID-19 can be understood by the region of the lung that is infected and can be divided into three phases that correspond to different clinical stages of the disease, which will be confined to the conducting airways and severe disease will involve the gas exchange portion of the lungs.Abstract:
COVID-19 can be understood by the region of the lung that is infected. Mild disease will be confined to the conducting airways and severe disease will involve the gas exchange portion of the lung.read more
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COVID-19 and the immune system
TL;DR: It has been revealed that cytotoxic CD8+ T cells exhibit functional exhaustion patterns, such as the expression of NKG2A, PD-1, and TIM-3, and IgM and IgG antibodies show similar dynamics in COVID-19 disease.
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Endothelial dysfunction in COVID-19: Current findings and therapeutic implications.
TL;DR: Endothelial dysfunction is a common feature of the key comorbidities that increase risk for severe COVID-19 such as hypertension, obesity, diabetes mellitus, coronary artery disease or heart failure and other treatments that are currently under investigation may act by improving endothelial dysfunction in patients.
Journal ArticleDOI
Ventilator-associated pneumonia in critically ill patients with COVID-19.
Mailis Maes,Ellen Higginson,Joana Pereira-Dias,Martin D. Curran,Surendra Parmar,Fahad A Khokhar,Delphine Cuchet-Lourenço,Janine Lux,Sapna Sharma-Hajela,Benjamin Ravenhill,Islam Hamed,Laura Heales,Razeen Mahroof,Amelia Solderholm,Sally Forrest,Sushmita Sridhar,Sushmita Sridhar,Nicholas M. Brown,Stephen Baker,Vilas Navapurkar,Gordon Dougan,Josefin Bartholdson Scott,Andrew Conway Morris,Andrew Conway Morris +23 more
TL;DR: In this article, the authors compared the incidence of VAP and secondary infections using a combination of microbial culture and a TaqMan multi-pathogen array, and determined the lung microbiome composition using 16S RNA analysis in a subset of samples.
Journal ArticleDOI
COVID-19: A Multidisciplinary Review
Nour Chams,Sana Chams,Reina Badran,Ali Shams,Abdallah Araji,Mohamad Raad,Sanjay Mukhopadhyay,Edana Stroberg,Eric J. Duval,Lisa M. Barton,Inaya Hajj Hussein +10 more
TL;DR: This comprehensive review discusses the current published literature surrounding the SARS-CoV-2 virus and identifies and provides insight into controversies and research gaps for the current pandemic to assist with future research ideas.
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CT in coronavirus disease 2019 (COVID-19): a systematic review of chest CT findings in 4410 adult patients.
TL;DR: Ground glass opacities (GGO) are the most prevalent chest CT findings in adult COVID-19 patients and the most common CT manifestations are bilateral, peripheral/subpleural, posterior GGOs with or without consolidations with a lower lobe predominance.
References
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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Markus Hoffmann,Hannah Kleine-Weber,Simon Schroeder,Nadine Krüger,Tanja Herrler,Sandra Erichsen,Tobias S. Schiergens,Georg Herrler,Nai Huei Wu,Andreas Nitsche,Marcel A. Müller,Christian Drosten,Christian Drosten,Stefan Pöhlmann +13 more
TL;DR: It is demonstrated that SARS-CoV-2 uses the SARS -CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming, and it is shown that the sera from convalescent SARS patients cross-neutralized Sars-2-S-driven entry.
Journal ArticleDOI
Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention
Zunyou Wu,Jennifer M. McGoogan +1 more
TL;DR: Hospitalised COVID-19 patients are frequently elderly subjects with co-morbidities receiving polypharmacy, all of which are known risk factors for d
Journal ArticleDOI
Pathological findings of COVID-19 associated with acute respiratory distress syndrome.
Zhe Xu,Lei Shi,Yijin Wang,Ji-Yuan Zhang,Lei Huang,Chao Zhang,Shuhong Liu,Peng Zhao,Hongxia Liu,Li Zhu,Yanhong Tai,Changqing Bai,Tingting Gao,Jin-Wen Song,Peng Xia,Jing-Hui Dong,Jingmin Zhao,Fu-Sheng Wang +17 more
TL;DR: O surto do novo coronavÃrus (COVID-19) em Wuhan, China, iniciado em dezembro de 2019, evoluiu para se tornar uma pandemia global A.
Journal ArticleDOI
Receptor Recognition by the Novel Coronavirus from Wuhan: an Analysis Based on Decade-Long Structural Studies of SARS Coronavirus.
TL;DR: These analyses provide insights into the receptor usage, cell entry, host cell infectivity and animal origin of 2019-nCoV and may help epidemic surveillance and preventive measures against 2019- nCoV.
Journal ArticleDOI
Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis.
Paul A. Reyfman,James M. Walter,Nikita Joshi,Kishore R. Anekalla,Alexandra C. McQuattie-Pimentel,Stephen Chiu,Ramiro Fernandez,Mahzad Akbarpour,Ching I. Chen,Ziyou Ren,Rohan Verma,Hiam Abdala-Valencia,Kiwon Nam,Monica Chi,SeungHye Han,Francisco J. Gonzalez-Gonzalez,Saul Soberanes,Satoshi Watanabe,Kinola J.N. Williams,Annette S. Flozak,Trevor T. Nicholson,Vince K. Morgan,Deborah R. Winter,Monique Hinchcliff,Cara L. Hrusch,Robert D. Guzy,Catherine A. Bonham,Anne I. Sperling,Remzi Bag,Robert B. Hamanaka,Gökhan M. Mutlu,Anjana Yeldandi,Stacy A. Marshall,Ali Shilatifard,Luís A. Nunes Amaral,Harris Perlman,Jacob I. Sznajder,A. Christine Argento,Colin T. Gillespie,Jane Dematte,Manu Jain,Benjamin D. Singer,Karen M. Ridge,Anna P. Lam,Ankit Bharat,Sangeeta Bhorade,Cara J. Gottardi,G. R. Scott Budinger,Alexander V. Misharin +48 more
TL;DR: The results support the feasibility of discovery-based approaches using next-generation sequencing technologies to identify signaling pathways for targeting in the development of personalized therapies for patients with pulmonary fibrosis.
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