Pathogenesis of COVID-19 from a cell biology perspective.
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COVID-19 can be understood by the region of the lung that is infected and can be divided into three phases that correspond to different clinical stages of the disease, which will be confined to the conducting airways and severe disease will involve the gas exchange portion of the lungs.Abstract:
COVID-19 can be understood by the region of the lung that is infected. Mild disease will be confined to the conducting airways and severe disease will involve the gas exchange portion of the lung.read more
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Pharmacological Activities of Fingerroot Extract and Its Phytoconstituents Against SARS-CoV-2 Infection in Golden Syrian Hamsters
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Olfactory dysfunction: A plausible source of COVID-19-induced neuropsychiatric symptoms
TL;DR: In this article , a mini-review article summarizes the neural correlates of olfaction and discusses the potential of trans-neuronal transmission of SARS-CoV-2 or its particles within the olfactory connections.
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Therapeutic Strategies in the Fight against COVID-19: From Bench to Bedside.
TL;DR: Wang et al. as discussed by the authors reviewed the latest data on therapeutic strategies undergoing clinical trials and provided a summary of vaccines currently under development, and discussed the latest clinical trials undergoing clinical trial.
Book ChapterDOI
SARS-CoV-2—host cell interactions and pathways: understanding its physiology, pathology, and targeted drug therapy
Rhea Conchita Gonsalves,Himavani Pacharla,S. Sai Manohar,Siva Kumar Belliraj,Ekta Tripathi,Prashanthi Karyala,Suresh B. Pakala +6 more
TL;DR: This chapter provides a comprehensive outline of the current status of the SARS-CoV-2 research, encompassing every step of the viral replication cycle with a specific focus on virus–host cell interaction.
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Investigation of Subcarinal Angle and Tracheobronchial Morphology in Patients with COVID 19: A Retrospective Computed Tomography Study
TL;DR: In this article , the trachea length, proximal, middle and distal levels anteroposterior (AP) and transverse (TR) diameters (TD), subcarinal angle (SA), proximal right main bronchus (RMB) and left main lungus (LMB) diameter were measured on CT images.
References
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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Markus Hoffmann,Hannah Kleine-Weber,Simon Schroeder,Nadine Krüger,Tanja Herrler,Sandra Erichsen,Tobias S. Schiergens,Georg Herrler,Nai Huei Wu,Andreas Nitsche,Marcel A. Müller,Christian Drosten,Christian Drosten,Stefan Pöhlmann +13 more
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Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention
Zunyou Wu,Jennifer M. McGoogan +1 more
TL;DR: Hospitalised COVID-19 patients are frequently elderly subjects with co-morbidities receiving polypharmacy, all of which are known risk factors for d
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Pathological findings of COVID-19 associated with acute respiratory distress syndrome.
Zhe Xu,Lei Shi,Yijin Wang,Ji-Yuan Zhang,Lei Huang,Chao Zhang,Shuhong Liu,Peng Zhao,Hongxia Liu,Li Zhu,Yanhong Tai,Changqing Bai,Tingting Gao,Jin-Wen Song,Peng Xia,Jing-Hui Dong,Jingmin Zhao,Fu-Sheng Wang +17 more
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Receptor Recognition by the Novel Coronavirus from Wuhan: an Analysis Based on Decade-Long Structural Studies of SARS Coronavirus.
TL;DR: These analyses provide insights into the receptor usage, cell entry, host cell infectivity and animal origin of 2019-nCoV and may help epidemic surveillance and preventive measures against 2019- nCoV.
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Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis.
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TL;DR: The results support the feasibility of discovery-based approaches using next-generation sequencing technologies to identify signaling pathways for targeting in the development of personalized therapies for patients with pulmonary fibrosis.
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