PEGylated enhanced cell penetrating peptide nanoparticles for lung gene therapy.
Gizem Osman,Jason Rodriguez,Sze Yan Chan,Jane Chisholm,Gregg A. Duncan,Namho Kim,Amanda L. Tatler,Kevin M. Shakesheff,Justin Hanes,Jung Soo Suk,Jung Soo Suk,James E. Dixon +11 more
TLDR
An innovative approach that combines novel GET peptides for enhanced transfection with a tuneable PEG coating for efficacious lung gene therapy is described.About:
This article is published in Journal of Controlled Release.The article was published on 2018-09-10 and is currently open access. It has received 125 citations till now. The article focuses on the topics: PEGylation & Biodistribution.read more
Citations
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Oligonucleotide therapy: An emerging focus area for drug delivery in chronic inflammatory respiratory diseases.
Meenu Mehta,Deeksha,Devesh Tewari,Gaurav Gupta,Rajendra Awasthi,Harjeet Singh,Parijat Pandey,Dinesh Kumar Chellappan,Ridhima Wadhwa,Trudi Collet,Philip M. Hansbro,S. Rajesh Kumar,Lakshmi Thangavelu,Poonam Negi,Kamal Dua,Kamal Dua,Kamal Dua,Saurabh Satija +17 more
TL;DR: Various novel dosage forms like nanoparticles, liposomes that can be used efficiently for the delivery of various oligonucleotides such as siRNA and miRNA are focused on.
Journal ArticleDOI
CFTR Modulators: The Changing Face of Cystic Fibrosis in the Era of Precision Medicine
TL;DR: A summary of recent developments in CFTR-directed therapeutics is provided in order to optimize treatment adherence, identify feasible and sustainable solutions for equitable access to these therapies, and continue to expand the pipeline of novel modulators that may result in effective precision medicine for all individuals with CF.
Journal ArticleDOI
Recent Advances in Cell Penetrating Peptide-Based Anticancer Therapies.
Justine Habault,Jean-Luc Poyet +1 more
TL;DR: Recent advances in the potential usage of CPPs in the context of cancer therapy are focused on, with a particular interest in CPP-mediated delivery of anti-tumoral proteins.
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Peptide–nanoparticle conjugates: a next generation of diagnostic and therapeutic platforms?
Woo Jin Jeong,Jiyoon Bu,Luke J. Kubiatowicz,Stephanie S. Chen,Young-Soo Kim,Seungpyo Hong,Seungpyo Hong +6 more
TL;DR: This paper provides a comprehensive overview of existing technologies that have been recently developed in the broad field of PNCs, offering a guideline especially for investigators who are new to this field.
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Cell Penetrating Peptides, Novel Vectors for Gene Therapy.
Rebecca E. Taylor,Maliha Zahid +1 more
TL;DR: The history, classification system, and mechanism of transduction followed by a summary of the existing literature on use of CPPs as gene delivery vectors either in the form of modified viruses, plasmid DNA, small interfering RNA, oligonucleotides, full-length genes, DNA origami or peptide nucleic acids are reviewed.
References
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Book
Cystic Fibrosis
TL;DR: Advances in understanding and treatment of cystic fibrosis are summarized, focusing on pulmonary disease, which accounts for most morbidity and deaths.
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Nanoparticle PEGylation for imaging and therapy
TL;DR: A background to investigators new to stealth nanoparticles is presented, and some key considerations needed prior to designing a nanoparticle PEGylation protocol and characterizing the performance features of the product are suggested.
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'Stealth' corona-core nanoparticles surface modified by polyethylene glycol (PEG): influences of the corona (PEG chain length and surface density) and of the core composition on phagocytic uptake and plasma protein adsorption.
Ruxandra Gref,Martin Lück,P. Quellec,M Marchand,Edith Dellacherie,Stephan Harnisch,Torsten Blunk,Rainer H. Müller +7 more
TL;DR: 2-D PAGE studies showed that plasma protein adsorption on PEG-coated PLA nanospheres strongly depends on the PEG molecular weight (Mw), which could be useful in the design of long circulating intravenously injectable biodegradable drug carriers endowed with protein resistant properties and low phagocytic uptake.
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Nanoparticle size and surface chemistry determine serum protein adsorption and macrophage uptake.
TL;DR: This study establishes principles for the rational design of clinically useful nanomaterials by investigating the role of size and surface chemistry in mediating serum protein adsorption to gold nanoparticles and their subsequent uptake by macrophages.
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Airway mucus function and dysfunction.
John V. Fahy,Burton F. Dickey +1 more
TL;DR: Pulmonary defense against environmental injury depends on airway mucus, which traps inhaled toxins that are then cleared from the lungs by ciliary beating and cough.