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Persistence of cccDNA During the Natural History of Chronic Hepatitis B and Decline During Adefovir Dipivoxil Therapy

Bettina Werle-Lapostolle, +16 more
- 01 Jun 2004 - 
- Vol. 126, Iss: 7, pp 1750-1758
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TLDR
cccDNA persists throughout the natural history of chronic hepatitis B, even in patients with serologic evidence of viral clearance, and long-term ADV therapy significantly decreased cccDNA levels by a primarily noncytolytic mechanism.
About: 
This article is published in Gastroenterology.The article was published on 2004-06-01 and is currently open access. It has received 827 citations till now. The article focuses on the topics: cccDNA & HBsAg.

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Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus

Huan Yan, +19 more
- 13 Nov 2012 - 
TL;DR: It is shown that the receptor-binding region of pre-S1 specifically interacts with sodium taurocholate cotransporting polypeptide (NTCP), a multiple transmembrane transporter predominantly expressed in the liver that is a functional receptor for HBV and HDV.
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Statements from the Taormina expert meeting on occult hepatitis B virus infection.

Giovanni Raimondo, +27 more
- 01 Oct 2008 - 
TL;DR: Giovanni Raimondo*, Jean-Pierre Allain, Maurizia R. Brunetto, Marie-Annick Buendia, Ding-Shinn Chen, Massimo Colombo, Antonio Craxi, Francesco Donato, Carlo Ferrari, Giovanni B. Gaeta, Wolfram H. Gerlich,Massimo Levrero, Stephen Locarnini, Thomas Michalak, Mario U. Zanetti, Fabien Zoulim
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Hepatitis B virus resistance to nucleos(t)ide analogues.

Fabien Zoulim, +2 more
- 01 Nov 2009 - 
TL;DR: It is important to continue basic research into HBV replication and pathogenic mechanisms to identify new therapeutic targets, develop novel antiviral agents, design combination therapies that prevent drug resistance, and decrease the incidence of complications of CHB.
Journal ArticleDOI

HBV cccDNA: viral persistence reservoir and key obstacle for a cure of chronic hepatitis B

Michael Nassal
- 03 Jun 2015 - 
TL;DR: This review aims to summarise current knowledge on ccc DNA molecular biology, to highlight the experimental restrictions that have hitherto hampered faster progress and to discuss cccDNA as target for new, potentially curative therapies of chronic hepatitis B.
Journal ArticleDOI

Occult hepatitis B virus infection

Giovanni Raimondo, +3 more
- 01 Jan 2007 - 
TL;DR: Much evidence suggests that hepatitis B virus can favour the progression of liver fibrosis and above all the development of hepatocellular carcinoma, and is an entity with world-wide diffusion.
References
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Journal ArticleDOI

Identification of a Reservoir for HIV-1 in Patients on Highly Active Antiretroviral Therapy

Diana Finzi, +14 more
- 14 Nov 1997 - 
TL;DR: In a study of 22 patients successfully treated with HAART for up to 30 months, replication-competent virus was routinely recovered from resting CD4+ T lymphocytes, and generally did not show mutations associated with resistance to the relevant antiretroviral drugs.
Journal ArticleDOI

Hepatitis B virus infection [1] (multiple letters)

Daniel Abramowicz, +2 more
- 30 Apr 1998 - 
Journal ArticleDOI

Hepatitis B virus infection.

William M. Lee
- 11 Dec 1997 - 
TL;DR: This review addresses many aspects of HBV infection, including the role of the immune system in determining the outcome of clinical infection, recent developments in molecular studies of the virus, and new treatments capable of eradicating chronic infection.
Journal ArticleDOI

Chronic hepatitis B

Anna S. Lok, +1 more
- 01 Dec 2001 - 
TL;DR: These guidelines have been written to assist physicians and other health care providers in the recognition, diagnosis, and management of patients chronically infected with the hepatitis B virus (HBV).
Journal ArticleDOI

Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy

Tae-Wook Chun, +8 more
- 25 Nov 1997 - 
TL;DR: Highly purified CD4+ T cells from patients receiving HAART with an average treatment time of 10 months and with undetectable plasma viremia carried integrated proviral DNA and were capable of producing infectious virus upon cellular activation in vitro, suggesting persistent active virus replication in vivo.
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Frequently Asked Questions (1)
Q1. What contributions have the authors mentioned in the paper "Persistence of cccdna during the natural history of chronic hepatitis b and decline during adefovir dipivoxil therapy" ?

The aim of this study was to develop a sensitive and specific assay quantifying cccDNA in biopsy samples from chronic hepatitis B patients during different natural history phases and in patients undergoing antiviral therapy.