Plasma microRNAs as potential biomarkers for non-small-cell lung cancer
Jun Shen,Nevins W. Todd,Howard Zhang,Lei Yu,Xing Lingxiao,Xing Lingxiao,Yuping Mei,Maria A. Guarnera,Jipei Liao,Amy Chou,Changwan Larry Lu,Zhengran Jiang,Hong-Bin Fang,Ruth L. Katz,Feng Jiang +14 more
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TLDR
Altered expressions of the miRNAs in plasma would provide potential blood-based biomarkers for NSCLC.About:
This article is published in Laboratory Investigation.The article was published on 2011-04-01 and is currently open access. It has received 365 citations till now. The article focuses on the topics: Lung cancer.read more
Citations
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MicroRNA signatures in tissues and plasma predict development and prognosis of computed tomography detected lung cancer
Mattia Boeri,Carla Verri,Davide Conte,Luca Roz,Piergiorgio Modena,Federica Facchinetti,Elisa Calabrò,Carlo M. Croce,Ugo Pastorino,Gabriella Sozzi +9 more
TL;DR: A role for miRNAs in lung tissues and plasma as molecular predictors of lung cancer development and aggressiveness is indicated and has theoretical and clinical implication for lung cancer management.
Journal ArticleDOI
Progress and prospects of early detection in lung cancer
Sean Knight,Phil A. Crosbie,Haval Balata,Jakub Chudziak,Tracy Hussell,Caroline Dive,Caroline Dive +6 more
TL;DR: Despite significant developments in the oncological management of late stage lung cancer over recent years, survival remains poor and the UK Office for National Statistics reported that patients diagnosed with distant metastatic disease had a 1-year survival rate of just 15–19% compared with 81–85% for stage I.
Journal ArticleDOI
microRNAs derived from circulating exosomes as noninvasive biomarkers for screening and diagnosing lung cancer
Riccardo Cazzoli,Fiamma Buttitta,Marta Di Nicola,Sara Malatesta,Antonio Marchetti,William N. Rom,Harvey I. Pass +6 more
TL;DR: Four microRNAs were selected to perform a screening test to discriminate between lung adenocarcinoma and granuloma, and the screening test showed 97.5% sensitivity, 72.0% specificity, and area under the curve receiver operating characteristic of 90.8%.
Journal ArticleDOI
Methodological challenges in utilizing miRNAs as circulating biomarkers.
TL;DR: Several key procedural aspects of miRNA isolation from plasma and serum are reported, as exemplified by research in cardiovascular and pulmonary diseases.
Journal ArticleDOI
Evaluation of Tumor-Derived Exosomal miRNA as Potential Diagnostic Biomarkers for Early-Stage Non–Small Cell Lung Cancer Using Next-Generation Sequencing
Xiance Jin,Yanfan Chen,Hanbin Chen,Shaoran Fei,Didi Chen,Xiaona Cai,Linger Liu,Baochai Lin,Huafang Su,Lihao Zhao,Meng Su,Huanle Pan,Lanxiao Shen,Deyao Xie,Congying Xie +14 more
TL;DR: Tumor-derived exosomal miRNAs, adenocarcinoma-specific miR-181-5p, mi-30a-3p,miR-30e- 3p and mi-361- 5p are identified and may be promising and effective candidates in the development of highly sensitive, noninvasive biomarkers for early NSCLC diagnosis.
References
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Cancer statistics, 2008.
Ahmedin Jemal,Rebecca L. Siegel,Elizabeth Ward,Yongping Hao,Jiaquan Xu,Taylor Murray,Michael J. Thun +6 more
TL;DR: This report examines cancer incidence, mortality, and survival by site, sex, race/ethnicity, education, geographic area, and calendar year, as well as the proportionate contribution of selected sites to the overall trends.
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MicroRNA expression profiles classify human cancers
Jun Lu,Gad Getz,Eric A. Miska,Eric A. Miska,Ezequiel Alvarez-Saavedra,Justin Lamb,David Peck,Alejandro Sweet-Cordero,Alejandro Sweet-Cordero,Benjamin L. Ebert,Benjamin L. Ebert,Raymond H. Mak,Raymond H. Mak,Adolfo A. Ferrando,James R. Downing,Tyler Jacks,H. Robert Horvitz,H. Robert Horvitz,Todd R. Golub,Todd R. Golub,Todd R. Golub +20 more
TL;DR: A new, bead-based flow cytometric miRNA expression profiling method is used to present a systematic expression analysis of 217 mammalian miRNAs from 334 samples, including multiple human cancers, and finds the miRNA profiles are surprisingly informative, reflecting the developmental lineage and differentiation state of the tumours.
Journal ArticleDOI
Circulating microRNAs as stable blood-based markers for cancer detection
Patrick S. Mitchell,Rachael K. Parkin,Evan M. Kroh,Brian R. Fritz,Brian R. Fritz,Stacia K. Wyman,Era L. Pogosova-Agadjanyan,Amelia Peterson,Jennifer Noteboom,Kathy O'Briant,April Allen,Daniel W. Lin,Daniel W. Lin,Daniel W. Lin,Nicole Urban,Charles W. Drescher,Beatrice S. Knudsen,Derek L. Stirewalt,Robert Gentleman,Robert L. Vessella,Robert L. Vessella,Peter S. Nelson,Daniel Martin,Daniel Martin,Muneesh Tewari +24 more
TL;DR: It is shown here that miRNAs are present in human plasma in a remarkably stable form that is protected from endogenous RNase activity and established the measurement of tumor-derived mi RNAs in serum or plasma as an important approach for the blood-based detection of human cancer.
Journal ArticleDOI
Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases
Xi Chen,Yi Ba,Lijia Ma,Lijia Ma,Xing Cai,Yuan Yin,Kehui Wang,Jigang Guo,Yujing Zhang,Jiangning Chen,Xing Guo,Qibin Li,Qibin Li,Xiaoying Li,Wenjing Wang,Yan Zhang,Jin Wang,Xueyuan Jiang,Yang Xiang,Chen Xu,Pingping Zheng,Juanbin Zhang,Ruiqiang Li,Hongjie Zhang,Xiaobin Shang,Ting Gong,Guang Ning,Jun Wang,Jun Wang,Ke Zen,Junfeng Zhang,Chen-Yu Zhang +31 more
TL;DR: It is demonstrated that miRNAs are present in the serum and plasma of humans and other animals such as mice, rats, bovine fetuses, calves, and horses, and can serve as potential biomarkers for the detection of various cancers and other diseases.
Journal ArticleDOI
Unique microRNA molecular profiles in lung cancer diagnosis and prognosis
Nozomu Yanaihara,Natasha J. Caplen,Elise D. Bowman,Masahiro Seike,Kensuke Kumamoto,Ming Yi,Robert M. Stephens,Aikou Okamoto,Jun Yokota,Tadao Tanaka,George A. Calin,Chang Gong Liu,Carlo M. Croce,Curtis C. Harris +13 more
TL;DR: Results indicate that miRNA expression profiles are diagnostic and prognostic markers of lung cancer.
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