Pro-resolving lipid mediators are leads for resolution physiology
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TLDR
The mechanisms of specialized pro-resolving mediators and omega-3 essential fatty acid pathways that could help us to understand their physiological functions are covered.Abstract:
Advances in our understanding of the mechanisms that bring about the resolution of acute inflammation have uncovered a new genus of pro-resolving lipid mediators that include the lipoxin, resolvin, protectin and maresin families, collectively called specialized pro-resolving mediators. Synthetic versions of these mediators have potent bioactions when administered in vivo. In animal experiments, the mediators evoke anti-inflammatory and novel pro-resolving mechanisms, and enhance microbial clearance. Although they have been identified in inflammation resolution, specialized pro-resolving mediators are conserved structures that also function in host defence, pain, organ protection and tissue remodelling. This Review covers the mechanisms of specialized pro-resolving mediators and omega-3 essential fatty acid pathways that could help us to understand their physiological functions.read more
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Receptors for pro-resolving mediators are increased in Alzheimer's disease brain.
Ceren Emre,Erik Hjorth,Krishna L. Bharani,Steven L. Carroll,Ann-Charlotte Granholm,Marianne Schultzberg +5 more
TL;DR: BLT1 and ChemR23 receptors were detected in neurons and glial cells in all examined regions of the human brain, with markedly higher levels in AD than in controls, and receptor levels correlated with the density of staining for the inflammation markers HLA‐DR and YKL‐40 for microglia and astrocytes, respectively.
Journal ArticleDOI
A role for 12/15-lipoxygenase-derived proresolving mediators in postoperative ileus: protectin DX-regulated neutrophil extravasation.
Kathy Stein,Melissa Stoffels,Mariola Lysson,Bianca Schneiker,Oliver Dewald,Gerhard Krönke,Jörg C. Kalff,Sven Wehner +7 more
TL;DR: Results show that 12/15‐lipoxygenase mediates postoperative ileus resolution via production of proresolving docosahexaenoic acid‐derived protectin DX.
Journal ArticleDOI
Perivascular delivery of resolvin D1 inhibits neointimal hyperplasia in a rabbit vein graft model.
Bian Wu,Evan C. Werlin,Mian Chen,Giorgio Mottola,Anuran Chatterjee,Kevin D. Lance,Daniel A. Bernards,Brian E. Sansbury,Matthew Spite,Tejal A. Desai,Michael S. Conte +10 more
TL;DR: Proof of concept for local delivery of resolvin D1 to reduce inflammation and to improve the healing response after vein bypass grafting is provided and provides further support for the potential therapeutic role of specialized proresolving lipid mediators such as D‐series resolvins in modulating vascular injury and repair.
Journal ArticleDOI
Novel leukotriene biosynthesis inhibitors (2012-2016) as anti-inflammatory agents.
TL;DR: The main focus is placed on the comprehensive discussion of recently reported inhibitors of 5-LO, FLAP, LTA4 hydrolase and LTC4 synthase, based on literature search (PubMed and Thomson Innovation Patents Searches), covering 2012–2016.
Journal ArticleDOI
Vitamin D prenatal programming of childhood metabolomics profiles at age 3 y
Kevin Blighe,Bo L. Chawes,Bo L. Chawes,Rachel S. Kelly,Hooman Mirzakhani,Michael J. McGeachie,Augusto A. Litonjua,Scott T. Weiss,Jessica Lasky-Su +8 more
TL;DR: The clusters differed in concentrations of inflammatory mediators, and cluster membership was influenced by in utero vitamin D exposure, suggesting a prenatal programming role of vitamin D on the child's metabolome.
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