Pro-resolving lipid mediators are leads for resolution physiology
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TLDR
The mechanisms of specialized pro-resolving mediators and omega-3 essential fatty acid pathways that could help us to understand their physiological functions are covered.Abstract:
Advances in our understanding of the mechanisms that bring about the resolution of acute inflammation have uncovered a new genus of pro-resolving lipid mediators that include the lipoxin, resolvin, protectin and maresin families, collectively called specialized pro-resolving mediators. Synthetic versions of these mediators have potent bioactions when administered in vivo. In animal experiments, the mediators evoke anti-inflammatory and novel pro-resolving mechanisms, and enhance microbial clearance. Although they have been identified in inflammation resolution, specialized pro-resolving mediators are conserved structures that also function in host defence, pain, organ protection and tissue remodelling. This Review covers the mechanisms of specialized pro-resolving mediators and omega-3 essential fatty acid pathways that could help us to understand their physiological functions.read more
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Frontline Science: Specialized proresolving lipid mediators inhibit the priming and activation of the macrophage NLRP3 inflammasome
A. Lopategi,Roger Flores-Costa,Bibiana Rius,Cristina López-Vicario,José Alcaraz-Quiles,Esther Titos,Joan Clària +6 more
TL;DR: The hypothesis that SPMs have the ability to inhibit the priming and to expedite the deactivation of the NLRP3 inflammasome in macrophages during the resolution process is supported.
Journal ArticleDOI
The G protein-coupled receptors deorphanization landscape.
TL;DR: An update of the various strategies employed to assign a function to these receptors and to discover new ligands is presented and several recommendations are proposed in order to strengthen the reporting of new ligand‐receptor pairs are proposed.
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Increased intermediate M1-M2 macrophage polarization and improved cognition in mild cognitive impairment patients on ω-3 supplementation.
Sam Famenini,Elizabeth A. Rigali,Henry M. Olivera-Perez,Johnny Dang,Michael To Chang,Ramesh C. Halder,Rammohan V. Rao,Matteo Pellegrini,Verna Porter,Dale E. Bredesen,Dale E. Bredesen,Milan Fiala +11 more
TL;DR: The hypothesis of this study was that active Aβ1–42 phagocytosis by macrophages prevents brain amyloidosis and thus maintains cognition in patients with mild cognitive impairment and brings into personalized clinical practice the immune benefits expected from ω‐3 mediators called resolvins.
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Omega-3 polyunsaturated fatty acids for cardiovascular diseases: present, past and future
Yasuhiro Watanabe,Ichiro Tatsuno +1 more
TL;DR: A large-scale epidemiological studies on Greenlandic, Canadian and Alaskan Eskimos have examined the health benefits of omega-3 fatty acids consumed as part of the diet, and found statistically significant relative reduction in cardiovascular risk in people consuming omega- 3 fatty acids.
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Impaired Resolution of Inflammation in Alzheimer's Disease: A Review.
TL;DR: Preclinical and clinical evidence support the hypothesis that AD is a neurodegenerative disorder where the impairment or failure of resolution contributes to the disease process and the literature supporting the potential therapeutic role of ω-3 FAs and specialized pro-resolving lipid mediators in the management of the disease is reviewed.
References
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