Pro-resolving lipid mediators are leads for resolution physiology
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TLDR
The mechanisms of specialized pro-resolving mediators and omega-3 essential fatty acid pathways that could help us to understand their physiological functions are covered.Abstract:
Advances in our understanding of the mechanisms that bring about the resolution of acute inflammation have uncovered a new genus of pro-resolving lipid mediators that include the lipoxin, resolvin, protectin and maresin families, collectively called specialized pro-resolving mediators. Synthetic versions of these mediators have potent bioactions when administered in vivo. In animal experiments, the mediators evoke anti-inflammatory and novel pro-resolving mechanisms, and enhance microbial clearance. Although they have been identified in inflammation resolution, specialized pro-resolving mediators are conserved structures that also function in host defence, pain, organ protection and tissue remodelling. This Review covers the mechanisms of specialized pro-resolving mediators and omega-3 essential fatty acid pathways that could help us to understand their physiological functions.read more
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Maresin 1 resolves aged-associated macrophage inflammation to improve bone regeneration.
TL;DR: The findings here identify resolution of inflammation, and MaR1 itself, to be a point of intervention to improve aged bone healing and to resolve inflammation after tibial fracture injury.
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Dienals derived from pyridinium salts and their subsequent application in natural product synthesis.
TL;DR: The goal of the present account is to survey the utility of dienals derived from pyridinium salts as the means to establish molecular architecture featured in natural products.
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Eicosanoid and Specialized Proresolving Mediator Regulation of Lymphoid Cells.
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Collagen I-based scaffolds negatively impact fracture healing in a mouse-osteotomy-model although used routinely in research and clinical application.
Annemarie Lang,Marieluise Kirchner,Jonathan Stefanowski,Mattea Durst,Marie-Christin Weber,Moritz Pfeiffenberger,Alexandra Damerau,Anja E. Hauser,Paula Hoff,Georg N. Duda,Frank Buttgereit,Katharina Schmidt-Bleek,Timo Gaber,Timo Gaber +13 more
TL;DR: The results of this study show for the first time a negative influence of both ACS-H and ACS-L on bone formation demonstrating a substantial need for more sophisticated delivery systems for local stimulation of bone healing in both clinical application and research.
References
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Journal ArticleDOI
Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
TL;DR: A better understanding of the molecular basis of myelomonocytic cell plasticity will open new vistas in immunopathology and therapeutic intervention and provide a paradigm for macrophage plasticity and function.
Journal ArticleDOI
Resolution of inflammation: the beginning programs the end.
Charles N. Serhan,John Savill +1 more
TL;DR: Emerging evidence now suggests that an active, coordinated program of resolution initiates in the first few hours after an inflammatory response begins, and the mechanism required for inflammation resolution may underpin the development of drugs that can resolve inflammatory processes in directed and controlled ways.
Journal ArticleDOI
Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals.
Charles N. Serhan,Song Hong,Karsten Gronert,Sean P. Colgan,Pallavi R. Devchand,Gudrun E. Mirick,Rose-Laure Moussignac +6 more
TL;DR: It is reported that lipidomic analysis of exudates obtained in the resolution phase from mice treated with ASA and docosahexaenoic acid produce a novel family of bioactive 17R-hydroxy-containing di- and tri-Hydroxy-docosanoids termed resolvins.
Journal ArticleDOI
Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases
TL;DR: Monotherapy blocking IL-1 activity in autoinflammatory syndromes results in a rapid and sustained reduction in disease severity, including reversal of inflammation-mediated loss of sight, hearing and organ function.
Journal ArticleDOI
The Human Serum Metabolome
Nikolaos Psychogios,David Hau,Jun Peng,An Chi Guo,Rupasri Mandal,Souhaila Bouatra,Igor Sinelnikov,Ramanarayan Krishnamurthy,Roman Eisner,Bijaya Gautam,Nelson Young,Jianguo Xia,Craig Knox,Edison Dong,Paul Huang,Zsuzsanna Hollander,Theresa L. Pedersen,Steven R. Smith,Fiona Bamforth,Russell Greiner,Bruce M. McManus,John W. Newman,Theodore L. Goodfriend,David S. Wishart,David S. Wishart +24 more
TL;DR: This work has combined targeted and non-targeted NMR, GC-MS and LC-MS methods with computer-aided literature mining to identify and quantify a comprehensive, if not absolutely complete, set of metabolites commonly detected and quantified (with today's technology) in the human serum metabolome.