Pro-resolving lipid mediators are leads for resolution physiology
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TLDR
The mechanisms of specialized pro-resolving mediators and omega-3 essential fatty acid pathways that could help us to understand their physiological functions are covered.Abstract:
Advances in our understanding of the mechanisms that bring about the resolution of acute inflammation have uncovered a new genus of pro-resolving lipid mediators that include the lipoxin, resolvin, protectin and maresin families, collectively called specialized pro-resolving mediators. Synthetic versions of these mediators have potent bioactions when administered in vivo. In animal experiments, the mediators evoke anti-inflammatory and novel pro-resolving mechanisms, and enhance microbial clearance. Although they have been identified in inflammation resolution, specialized pro-resolving mediators are conserved structures that also function in host defence, pain, organ protection and tissue remodelling. This Review covers the mechanisms of specialized pro-resolving mediators and omega-3 essential fatty acid pathways that could help us to understand their physiological functions.read more
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Inverse Relationship between Serum Lipoxin A4 Level and the Risk of Metabolic Syndrome in a Middle-Aged Chinese Population.
TL;DR: Investigation of the relationship between serum lipoxin A4 (LXA4) level and the risk of incident MetS in a middle-aged Chinese population suggests that serum LXA4 levels might be useful for early detection and prevention of Mets.
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Anti-inflammatory role of 15-lipoxygenase contributes to the maintenance of skin integrity in mice
Sang Nam Kim,Seun Akindehin,Hyun Jung Kwon,Yeon Ho Son,Abhirup Saha,Young Suk Jung,Je Kyung Seong,Kyung Min Lim,Jong Hyuk Sung,Krishna Rao Maddipati,Yun Hee Lee +10 more
TL;DR: It is indicated that Alox15-mediated production of resolvin D2 is required to maintain skin integrity by suppressing dermal inflammation.
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Fish skin grafts compared to human amnion/chorion membrane allografts: A double-blind, prospective, randomized clinical trial of acute wound healing.
Robert S. Kirsner,David J. Margolis,Baldur Baldursson,Kristin Petursdottir,Olafur B. Davidsson,Dot Weir,John C Lantis +6 more
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Can pleiotropic effects of eicosapentaenoic acid (EPA) impact residual cardiovascular risk
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Distinct fatty acid signatures in infrapatellar fat pad and synovial fluid of patients with osteoarthritis versus rheumatoid arthritis
Anne-Mari Mustonen,Reijo Käkelä,Petri Lehenkari,Petri Lehenkari,Johanna A. Huhtakangas,Johanna A. Huhtakangas,Sanna Turunen,Sanna Turunen,Antti Joukainen,Tommi Kääriäinen,Tommi Paakkonen,Heikki Kröger,Petteri Nieminen +12 more
TL;DR: The observed complex alterations in the FA signatures could have both contributed to but also limited the inflammatory processes and cartilage destruction in the RA and OA knees.
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