Prostaglandin D2 Selectively Induces Chemotaxis in T Helper Type 2 Cells, Eosinophils, and Basophils via Seven-Transmembrane Receptor Crth2
Hiroyuki Hirai,Kazuya Tanaka,Osamu Yoshie,Kazuyuki Ogawa,Kazumi Kenmotsu,Yasushi Takamori,Michiko Ichimasa,Kazuo Sugamura,Masataka Nakamura,Shoichi Takano,Kinya Nagata +10 more
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TLDR
It is shown that a seven-transmembrane receptor, CRTH2, which is preferentially expressed in T helper type 2 (Th2) cells, eosinophils, and basophils in humans, serves as the novel receptor for PGD2.Abstract:
Prostaglandin (PG)D2, which has long been implicated in allergic diseases, is currently considered to elicit its biological actions through the DP receptor (DP). Involvement of DP in the formation of allergic asthma was recently demonstrated with DP-deficient mice. However, proinflammatory functions of PGD2 cannot be explained by DP alone. We show here that a seven-transmembrane receptor, CRTH2, which is preferentially expressed in T helper type 2 (Th2) cells, eosinophils, and basophils in humans, serves as the novel receptor for PGD2. In response to PGD2, CRTH2 induces intracellular Ca2+ mobilization and chemotaxis in Th2 cells in a Gαi-dependent manner. In addition, CRTH2, but not DP, mediates PGD2-dependent cell migration of blood eosinophils and basophils. Thus, PGD2 is likely involved in multiple aspects of allergic inflammation through its dual receptor systems, DP and CRTH2.read more
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References
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Journal ArticleDOI
Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
Journal ArticleDOI
Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma
Douglas S. Robinson,Qutayba Hamid,Sun Ying,Anne Tsicopoulos,J. Barkans,Andrew Bentley,Christopher Corrigan,Stephen R. Durham,A. B. Kay +8 more
TL;DR: Atopic asthma is associated with activation in the bronchi of the interleukin-3, 4, and 5 and GM-CSF gene cluster, a pattern compatible with predominant activation of the TH2-like T-cell population.
Journal ArticleDOI
Prostanoid Receptors: Structures, Properties, and Functions
TL;DR: An overview of the current status of research on the prostanoid receptors is given and domains and amino acid residues conferring the specificities of ligand binding and signal transduction are being clarified.
Journal ArticleDOI
The Molecular Biology of Leukocyte Chemoattractant Receptors
TL;DR: Surprising developments suggest that in addition to leukocyte-mediated inflammation, the chemokines may also be involved in erythrocyte function and, through molecular mimicry, in microbial pathogenesis.
Journal ArticleDOI
Chemokines and chemokine receptors in T-cell priming and Th1/Th2-mediated responses
TL;DR: The role played by chemokines and chemokine receptors in positioning T cells for the immune response is reviewed, with a focus on T-cell priming and delayed-type hypersensitivity or allergic reactions.