Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing DNA double-strand break ubiquitination
Kyosuke Nakamura,Georg Kustatscher,Constance Alabert,Martina Hödl,Ignasi Forné,Moritz Völker-Albert,Shankha Satpathy,Tracey E. Beyer,Niels Mailand,Chunaram Choudhary,Axel Imhof,Juri Rappsilber,Juri Rappsilber,Anja Groth +13 more
TLDR
In this article, the authors used nascent chromatin capture (NCC) proteomics to characterize the repair of replication-associated DNA double-strand breaks (DSBs) triggered by topoisomerase 1 (TOP1) inhibitors.About:
This article is published in Molecular Cell.The article was published on 2021-03-04 and is currently open access. It has received 37 citations till now. The article focuses on the topics: DNA repair & DNA replication.read more
Citations
More filters
Journal ArticleDOI
Talazoparib monotherapy in metastatic castration-resistant prostate cancer with DNA repair alterations (TALAPRO-1): an open-label, phase 2 trial
Johann S. de Bono,Niven Mehra,Giorgio V. Scagliotti,Elena Castro,Tanya B. Dorff,A. Stirling,Arnulf Stenzl,Mark D. Fleming,Celestia S. Higano,Fred Saad,Consuelo Buttigliero,Inge M. van Oort,A. Douglas Laird,Marielena Mata,Hsiang-Chun Chen,Cynthia G. Healy,Akos Czibere,Karim Fizazi +17 more
TL;DR: In this paper, the authors assessed the PARP inhibitor talazoparib in metastatic castration-resistant prostate cancers with DNA damage response (DDR) alterations in genes involved directly or indirectly in homologous recombination repair (HRR).
Journal ArticleDOI
Human topoisomerases and their roles in genome stability and organization
TL;DR: Topoisomerases are a family of six enzymes: TOP1 and TOP1MT, TOP2A and TOP2B, and two types IA and TOP3A as discussed by the authors .
Journal ArticleDOI
Cellular functions of the protein kinase ATM and their relevance to human disease.
Ji-Hoon Lee,Tanya T. Paull +1 more
TL;DR: The protein kinase ataxia telangiectasia mutated (ATM) is a master regulator of double-strand DNA break (DSB) signalling and stress responses as discussed by the authors.
Journal ArticleDOI
Hallmarks of DNA replication stress.
Sneha Saxena,Lee Zou +1 more
TL;DR: A review on the major sources of replication stress, the impacts of DNA replication stress in cells, and the assays to detect replication stress can be found in this paper , which provides an overview of the hallmarks of the replication stress.
Journal ArticleDOI
Present and Future Perspective on PLK1 Inhibition in Cancer Treatment
Michela Chiappa,Sabrina Petrella,Giovanna Damia,Massimo Broggini,Federica Guffanti,Francesco Ricci +5 more
TL;DR: The evidence suggesting the role of PLK1 in response to DNA damage, including DNA repair, cell cycle progression, epithelial to mesenchymal transition, cell death pathways and cancer-related immunity is summarized.
References
More filters
Book ChapterDOI
Proteomic Analyses of the Eukaryotic Replication Machinery.
TL;DR: Experimental approaches to purification, identification, and quantification of the replication, chromatin maturation, and replication stress response machineries, including iPOND and NCC, are introduced and examined.
Journal ArticleDOI
Inhibitors of topoisomerases I and II arrest DNA replication, but do not prevent nucleosome assembly in vivo.
TL;DR: Evidence is provided that, although topoisomerase activity is essential for DNA replication, neither continuous fork propagation nor topoisome activity is required for chromatin assembly on new DNA.
Journal ArticleDOI
PLK1 is a critical determinant of tumor cell sensitivity to CPT11 and its inhibition enhances the drug antitumor efficacy in squamous cell carcinoma models sensitive and resistant to camptothecins
TL;DR: PLK1 inhibition represents a promising strategy to improve the antitumor efficacy of CPT11-based regimens and is reflected in a high rate of complete responses and cures in mice harboring SCC, including tumors with intrinsic or acquired resistance to CPTs.
Journal ArticleDOI
SNHG20/miR-140-5p/NDRG3 axis contributes to 5-fluorouracil resistance in gastric cancer.
Jie Yu,Jie Shen,Xu Qiao,Longlei Cao,Zhang-Ling Yang,Hui Ye,Changlei Xi,Qichang Zhou,Peiyun Wang,Zhilin Gong +9 more
TL;DR: It is suggested that the small nucleolar RNA host gene 20 (SNHG20)/microRNA (miR)-140-5p/NDRG3 axis may be involved in mediating resistance to 5-FU in gastric cancer.
Book ChapterDOI
Detection of Histone Modification Dynamics during the Cell Cycle by MS-Based Proteomics
TL;DR: A pulsed-SILAC approach is described to distinguish newly synthesized and deposited histones during S-phase of the cell cycle from parental "old" histones incorporated in previous replications and to decipher posttranslational histone modifications (PTMs).
Related Papers (5)
Interplay of replication checkpoints and repair proteins at stalled replication forks.
Dana Branzei,Marco Foiani +1 more
Building up and breaking down: mechanisms controlling recombination during replication.
Dana Branzei,Barnabas Szakal +1 more