Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing DNA double-strand break ubiquitination
Kyosuke Nakamura,Georg Kustatscher,Constance Alabert,Martina Hödl,Ignasi Forné,Moritz Völker-Albert,Shankha Satpathy,Tracey E. Beyer,Niels Mailand,Chunaram Choudhary,Axel Imhof,Juri Rappsilber,Juri Rappsilber,Anja Groth +13 more
TLDR
In this article, the authors used nascent chromatin capture (NCC) proteomics to characterize the repair of replication-associated DNA double-strand breaks (DSBs) triggered by topoisomerase 1 (TOP1) inhibitors.About:
This article is published in Molecular Cell.The article was published on 2021-03-04 and is currently open access. It has received 37 citations till now. The article focuses on the topics: DNA repair & DNA replication.read more
Citations
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Talazoparib monotherapy in metastatic castration-resistant prostate cancer with DNA repair alterations (TALAPRO-1): an open-label, phase 2 trial
Johann S. de Bono,Niven Mehra,Giorgio V. Scagliotti,Elena Castro,Tanya B. Dorff,A. Stirling,Arnulf Stenzl,Mark D. Fleming,Celestia S. Higano,Fred Saad,Consuelo Buttigliero,Inge M. van Oort,A. Douglas Laird,Marielena Mata,Hsiang-Chun Chen,Cynthia G. Healy,Akos Czibere,Karim Fizazi +17 more
TL;DR: In this paper, the authors assessed the PARP inhibitor talazoparib in metastatic castration-resistant prostate cancers with DNA damage response (DDR) alterations in genes involved directly or indirectly in homologous recombination repair (HRR).
Journal ArticleDOI
Human topoisomerases and their roles in genome stability and organization
TL;DR: Topoisomerases are a family of six enzymes: TOP1 and TOP1MT, TOP2A and TOP2B, and two types IA and TOP3A as discussed by the authors .
Journal ArticleDOI
Cellular functions of the protein kinase ATM and their relevance to human disease.
Ji-Hoon Lee,Tanya T. Paull +1 more
TL;DR: The protein kinase ataxia telangiectasia mutated (ATM) is a master regulator of double-strand DNA break (DSB) signalling and stress responses as discussed by the authors.
Journal ArticleDOI
Hallmarks of DNA replication stress.
Sneha Saxena,Lee Zou +1 more
TL;DR: A review on the major sources of replication stress, the impacts of DNA replication stress in cells, and the assays to detect replication stress can be found in this paper , which provides an overview of the hallmarks of the replication stress.
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Present and Future Perspective on PLK1 Inhibition in Cancer Treatment
Michela Chiappa,Sabrina Petrella,Giovanna Damia,Massimo Broggini,Federica Guffanti,Francesco Ricci +5 more
TL;DR: The evidence suggesting the role of PLK1 in response to DNA damage, including DNA repair, cell cycle progression, epithelial to mesenchymal transition, cell death pathways and cancer-related immunity is summarized.
References
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H4K20me0 marks post-replicative chromatin and recruits the TONSL–MMS22L DNA repair complex
Giulia Saredi,Hongda Huang,Colin Hammond,Constance Alabert,Simon Bekker-Jensen,Ignasi Forné,Nazaret Reverón-Gómez,Benjamin M. Foster,Lucie J Mlejnkova,Till Bartke,Petr Cejka,Niels Mailand,Axel Imhof,Dinshaw J. Patel,Anja Groth +14 more
TL;DR: It is revealed that new histones incorporated during DNA replication provide a signature of post-replicative chromatin, read by the human TONSL–MMS22L homologous recombination complex, offering a new angle to understand DNA repair with the potential for targeted cancer therapy.
Journal ArticleDOI
Shieldin - the protector of DNA ends.
TL;DR: The identification of shieldin and the various models of Shieldin action are summarized and some outstanding questions requiring answers are highlighted to gain a full molecular understanding of shieldIn function.
Journal ArticleDOI
Targeting Topoisomerase I in the Era of Precision Medicine
Anish Thomas,Yves Pommier +1 more
TL;DR: New therapeutic strategies based on novel TOP1 inhibitor chemical scaffolds including the indenoisoquinolines LMP400, LMP776, and LMP744 are introduced, and on tumor-targeted delivery TOP1 inhibitors using liposome, PEGylation, and antibody–drug conjugates are addressed.
Journal ArticleDOI
Replication-Coupled DNA Repair.
TL;DR: This review provides a broad overview of replication-coupled repair pathways, explaining how they fix polymerase mistakes, respond to template damage that acts as obstacles to the replisome, deal with broken forks, and impact human health and disease.
Journal ArticleDOI
Histone ubiquitination in the DNA damage response.
Michael Uckelmann,Titia K. Sixma +1 more
TL;DR: This work proposes a model where site-specific H2A ubiquitination organizes the spatio-temporal recruitment of DNA repair factors which will ultimately contribute to DNA repair pathway choice between homologous recombination and non-homologous end joining.
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