Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing DNA double-strand break ubiquitination
Kyosuke Nakamura,Georg Kustatscher,Constance Alabert,Martina Hödl,Ignasi Forné,Moritz Völker-Albert,Shankha Satpathy,Tracey E. Beyer,Niels Mailand,Chunaram Choudhary,Axel Imhof,Juri Rappsilber,Juri Rappsilber,Anja Groth +13 more
TLDR
In this article, the authors used nascent chromatin capture (NCC) proteomics to characterize the repair of replication-associated DNA double-strand breaks (DSBs) triggered by topoisomerase 1 (TOP1) inhibitors.About:
This article is published in Molecular Cell.The article was published on 2021-03-04 and is currently open access. It has received 37 citations till now. The article focuses on the topics: DNA repair & DNA replication.read more
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Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA ubiquitination.
Yi Chang Wang,Andrew A. Kelso,Adak Karamafrooz,Yi-Hsuan Chen,Wei-Kai Chen,Chun Ting Cheng,Ye Qi,Long Gu,Linda H. Malkas,Angelo Taglialatela,Hsing Jien Kung,George Lucian Moldovan,Alberto Ciccia,Jeremy M. Stark,David K. Ann +14 more
TL;DR: In this paper , the impact of arginine availability on DNA replication and genotoxicity resistance was examined using DNA combing assays, and it was shown that limiting extracellular arginines results in the arrest of cancer cells at S phase and a slowing or stalling of DNA replication.
Journal ArticleDOI
Dynamic de novo heterochromatin assembly and disassembly at replication forks ensures fork stability
Vincent Gaggioli,Calvin Shun Yu Lo,Nazaret Reverón-Gómez,Zuzana Jasencakova,S. Sidoli,Andrey Tvardovskiy,Sidrit Uruci,Johan A. Slotman,João G. S. C. Souto Gonçalves,Eleni Maria Manolika,Ole N. Jensen,David A. Wheeler,Sriram Sridharan,Sanjiban Chakrabarty,Jeroen Demmers,Roland Kanaar,Anja Groth,Nitika Taneja +17 more
TL;DR: In this paper , a checkpoint-regulated cascade of chromatin signalling that activates the histone methyltransferase EHMT2/G9a to catalyse heterochromatin assembly at stressed replication forks is discovered.
References
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