Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules
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TLDR
Novel pathways contributing significantly to the understanding of HIF-1 regulation which may be major determinants of tumor radiosensitivity, potentially having high clinical relevance are described.About:
This article is published in Cancer Cell.The article was published on 2004-05-01 and is currently open access. It has received 928 citations till now. The article focuses on the topics: Radiosensitivity & Angiogenesis.read more
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Book ChapterDOI
Mechanisms by Which Manganese Porphyrins Affect Signaling in Cancer Cells
TL;DR: It is hypothesized that by scavenging superoxide and enhancing hydrogen peroxide levels, the manganese porphyrins directly affect redox signaling pathways resulting in reduced tumor growth.
Journal ArticleDOI
The Protein Phosphatase PPM1G Destabilizes HIF-1α Expression
TL;DR: It is found that overexpression of Mg2+/Mn2+-dependent protein phosphatase 1 gamma (PPM1G), one of Ser/Thrprotein phosphatases, downregulated protein expression of ectopic HIF-1α under normoxic or acute hypoxic conditions and that PPM1g is critical for the control of Hif-1 α-dependent responses.
Journal ArticleDOI
Low Rap1-interacting factor 1 and sirtuin 6 expression predict poor outcome in radiotherapy-treated Hodgkin lymphoma patients.
Hamid Bur,Kirsi-Maria Haapasaari,Taina Turpeenniemi-Hujanen,Outi Kuittinen,Päivi Auvinen,Katja Marin,Ylermi Soini,Peeter Karihtala +7 more
TL;DR: In this article, the expression levels of SIRT1, 4, SIRT6, Rif1, and O6-alkylguanine DNA alkyltransferase (MGMT) were found abnormally distributed in Reed-Sternberg (RS) cells compared with reactive elements.
Patent
Pharmaceutical composition for inhibiting the transcription factor inducible by hypoxia, modulators of pathological processes of angiogenesis, oncogenesis, inflammation, apoptosis, and cellular therapy
Olmo Raquel Garijo,Tárrega Chiva,Bonilla José Luis Aceña,Jiménez Francisco Javier Rodríguez,Rivera Rosa Farrás,Domínguez Rut Lucas,Sanjosé José Luis Mullor,Juan Francisco Sanz-Cervera,Manzano Moreno,Lardíes Santos Fustero,González-Carvajal Sánchez-Puelles +10 more
TL;DR: In this article, a method for the synthesis of molecules represented by general formula (I) and the use thereof in the production of a medicament for the treatment of pathological processes related to cancer, inflammation, tissue repair, stem cell differentiation and regenerative therapy is presented.
References
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Role of angiogenesis in tumor growth and metastasis
TL;DR: Preclinical studies have shown that endostatin effectively inhibits tumor growth and shrinks existing tumor blood vessels and therapy with endogenous inhibitors of angiogenesis, such asendostatin and angiostatin may reverse the angiogenic switch preventing growth of tumor vasculature.
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Mitochondrial reactive oxygen species trigger hypoxia-induced transcription
Navdeep S. Chandel,Emin Maltepe,Eugene Goldwasser,Carol Mathieu,M. C. Simon,Paul T. Schumacker +5 more
TL;DR: In this paper, the authors tested whether mitochondria act as O2 sensors during hypoxia and whether cobalt activated transcription by increasing the generation of reactive oxygen species (ROS).
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Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing.
Navdeep S. Chandel,David S. McClintock,C E Feliciano,T M Wood,J A Melendez,A M Rodriguez,Paul T. Schumacker +6 more
TL;DR: Findings reveal that mitochondria-derived ROS are both required and sufficient to initiate HIF-1α stabilization during hypoxia and that catalase abolishes hypoxic response element-luciferase expression during Hypoxia.
Journal ArticleDOI
Tumor Response to Radiotherapy Regulated by Endothelial Cell Apoptosis
Monica Garcia-Barros,François Paris,Carlos Cordon-Cardo,David Lyden,Shahin Rafii,Adriana Haimovitz-Friedman,Zvi Fuks,Richard Kolesnick +7 more
TL;DR: Microvascular damage regulates tumor cell response to radiation at the clinically relevant dose range, indicating that endothelial apoptosis is a homeostatic factor regulating angiogenesis-dependent tumor growth.
Journal ArticleDOI
Vascular Endothelial Growth Factor
TL;DR: A historic account of the challenges associated with the discovery of VEGF and the early steps in elucidating the role of this molecule in the regulation of angiogenesis is provided.