Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules
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TLDR
Novel pathways contributing significantly to the understanding of HIF-1 regulation which may be major determinants of tumor radiosensitivity, potentially having high clinical relevance are described.About:
This article is published in Cancer Cell.The article was published on 2004-05-01 and is currently open access. It has received 928 citations till now. The article focuses on the topics: Radiosensitivity & Angiogenesis.read more
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Why do cancers have high aerobic glycolysis
TL;DR: In this article, the authors propose that persistent metabolism of glucose to lactate even in aerobic conditions is an adaptation to intermittent hypoxia in pre-malignant lesions, which leads to microenvironmental acidosis requiring evolution to phenotypes resistant to acid-induced cell toxicity.
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Targeting hypoxia in cancer therapy
William R. Wilson,Michael P. Hay +1 more
TL;DR: The two main approaches, namely bioreductive prodrugs and inhibitors of molecular targets upon which hypoxic cell survival depends are reviewed, and the particular challenges and opportunities these overlapping strategies present are addressed.
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HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
TL;DR: It is shown by genetic means that HIF-1-dependent block to oxygen utilization results in increased oxygen availability, decreased cell death when total oxygen is limiting, and reduced cell death in response to the hypoxic cytotoxin tirapazamine.
Journal ArticleDOI
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
TL;DR: This review summarizes the current state of knowledge regarding the molecular mechanisms by which Hif-1 contributes to cancer progression, focusing on clinical data associating increased HIF-1 levels with patient mortality and pharmacological data showing anticancer effects of H IF-1 inhibitors in mouse models of human cancer.
Journal ArticleDOI
STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors
Liufu Deng,Hua Liang,Meng Xu,Xuanming Yang,Byron Burnette,Ainhoa Arina,Xiao Dong Li,Helena J. Mauceri,Michael A. Beckett,Thomas E. Darga,Xiaona Huang,Thomas F. Gajewski,Zhijian J. Chen,Yang Xin Fu,Ralph R. Weichselbaum +14 more
TL;DR: Radiation-mediated antitumor immunity in immunogenic tumors requires a functional cytosolic DNA-sensing pathway and suggests that cGAMP treatment might provide a new strategy to improve radiotherapy.
References
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Vanadate-induced Expression of Hypoxia-inducible Factor 1α and Vascular Endothelial Growth Factor through Phosphatidylinositol 3-Kinase/Akt Pathway and Reactive Oxygen Species
Ning Gao,Min Ding,Jenny Z. Zheng,Zhuo Zhang,Stephen S. Leonard,Ke Jian Liu,Xianglin Shi,Bing-Hua Jiang +7 more
TL;DR: The results suggest that the expression of HIF-1 and VEGF induced by vanadate through PI3K/Akt may be an important signaling pathway in theVanadate-induced carcinogenesis, and ROS may play an important role.
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Effect of VEGF receptor inhibitor PTK787/ZK222548 combined with ionizing radiation on endothelial cells and tumour growth
C Hess,Van Vuong,I. Hegyi,Oliver Riesterer,Jeanette Marjorie Wood,Doriano Fabbro,Christoph Glanzmann,Stephan Bodis,Martin Pruschy +8 more
TL;DR: The model of a cooperative antitumoural effect of angiogenesis inhibitor and irradiation is supported and it is shown that the orally bioavailable VEGF receptor tyrosine kinase inhibitor PTK787/ZK222584 is suitable for combination therapy with irradiation.
Journal Article
Phosphatidylinositol 3-kinase/Akt signaling in the response of vascular endothelium to ionizing radiation.
TL;DR: Tumor vascular window and Doppler ultrasound showed that PI3K antagonists enhanced radiation-induced destruction of tumor blood vessels, and PI3k in tumor vascular endothelium is a potential therapeutic target to enhance the efficacy of ionizing radiation.
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Transferrin promotes endothelial cell migration and invasion: implication in cartilage neovascularization.
Mariella F. Carlevaro,Adriana Albini,Domenico Ribatti,Chiara Gentili,Roberto Benelli,Silvia Cermelli,Ranieri Cancedda,Fiorella Descalzi Cancedda +7 more
TL;DR: It is indicated that transferrin is a major angiogenic molecule produced by hypertrophic chondrocytes during endochondral bone formation and promoted of neovascularization by transferrins purified from different sources including conditioned culture medium.
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The antiangiogenic agents SU5416 and SU6668 increase the antitumor effects of fractionated irradiation
TL;DR: The results suggest that inhibition of Vegf, Fgf and Pdgf receptor function by SU5416 and SU6668 can enhance the efficacy of irradiation.