Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules
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TLDR
Novel pathways contributing significantly to the understanding of HIF-1 regulation which may be major determinants of tumor radiosensitivity, potentially having high clinical relevance are described.About:
This article is published in Cancer Cell.The article was published on 2004-05-01 and is currently open access. It has received 928 citations till now. The article focuses on the topics: Radiosensitivity & Angiogenesis.read more
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Genetic Variability of Antioxidative Mechanisms and Cardiotoxicity after Adjuvant Radiotherapy in HER2-Positive Breast Cancer Patients.
TL;DR: In this article, the association of common polymorphisms in antioxidative genes with cardiotoxicity after adjuvant radiotherapy (RT) in HER2-positive breast cancer patients was evaluated.
Journal ArticleDOI
Radiation with immunotherapy: an emerging combination for cancer treatment
Wen Jiang,Chad Tang,Joe Y. Chang +2 more
TL;DR: The fundamental immunogenic properties of RT are outlined and an overview of the clinical experience thus far that support the combination of RT with immunotherapy in cancer treatments are presented.
Journal ArticleDOI
Novel Imaging Approaches to Head and Neck Cancer
Kenneth A. Krohn,Bevan Yeuh +1 more
TL;DR: Hypoxia has been shown to be important in overall diminished therapeutic response, malignant progression, increased probability of recurrence, locoregional spread, and distant metastases, and how information about the oxygenation status of tumors might impact treatment.
Proceedings ArticleDOI
Measurement of hemoglobin saturation in tumor microvasculature in preclinical models using hyperspectral imaging
TL;DR: A hyperspectral imaging system has been constructed to create image maps of hemoglobin saturation in microvasculature of tumors grown in dorsal skin-fold window chambers, and preliminary baseline studies of early tumor development using 4T1 mouse mammary carcinomas are currently being conducted with the system.
Journal ArticleDOI
Effects of reactive oxygen species on metabolism monitored by longitudinal 1 H single voxel MRS follow-up in patients with mitochondrial disease or cerebral tumors
Jean-Marc Constans,Solène Collet,Jean-Sébastien Guillamo,Gabriela Hossu,Gabriela Hossu,S Lacombe,Y A Gauduel,C. Houée Levin,W. Dou,Su Ruan,Louisa Barré,François Rioult,J M Derlon,Emmanuèle Lechapt-Zalcman,Samuel Valable,Françoise Chapon,Patrick Courtheoux,V Fong,F. Kauffmann +18 more
TL;DR: In this paper, the effects of free radicals on energy and glycolytic metabolism, mitochondrial function, lipid metabolism, necrosis and apoptosis, cell proliferation, and infiltration were monitored longitudinally (every 4 months over 6 years) in humans with glial brain tumors (low and high grade) after therapy.
References
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Role of angiogenesis in tumor growth and metastasis
TL;DR: Preclinical studies have shown that endostatin effectively inhibits tumor growth and shrinks existing tumor blood vessels and therapy with endogenous inhibitors of angiogenesis, such asendostatin and angiostatin may reverse the angiogenic switch preventing growth of tumor vasculature.
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Mitochondrial reactive oxygen species trigger hypoxia-induced transcription
Navdeep S. Chandel,Emin Maltepe,Eugene Goldwasser,Carol Mathieu,M. C. Simon,Paul T. Schumacker +5 more
TL;DR: In this paper, the authors tested whether mitochondria act as O2 sensors during hypoxia and whether cobalt activated transcription by increasing the generation of reactive oxygen species (ROS).
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Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing.
Navdeep S. Chandel,David S. McClintock,C E Feliciano,T M Wood,J A Melendez,A M Rodriguez,Paul T. Schumacker +6 more
TL;DR: Findings reveal that mitochondria-derived ROS are both required and sufficient to initiate HIF-1α stabilization during hypoxia and that catalase abolishes hypoxic response element-luciferase expression during Hypoxia.
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Tumor Response to Radiotherapy Regulated by Endothelial Cell Apoptosis
Monica Garcia-Barros,François Paris,Carlos Cordon-Cardo,David Lyden,Shahin Rafii,Adriana Haimovitz-Friedman,Zvi Fuks,Richard Kolesnick +7 more
TL;DR: Microvascular damage regulates tumor cell response to radiation at the clinically relevant dose range, indicating that endothelial apoptosis is a homeostatic factor regulating angiogenesis-dependent tumor growth.
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Vascular Endothelial Growth Factor
TL;DR: A historic account of the challenges associated with the discovery of VEGF and the early steps in elucidating the role of this molecule in the regulation of angiogenesis is provided.